The role of garlic oil in the amelioration of oxidative stress and tissue damage in rohu Labeo rohita treated with silver nanoparticles

Khan, M. S.; Qureshi, Naureen Aziz; Jabeen, Farhat; Wajid, Muhammad; Sabri, Sabeen; Shakir, Muhammad

doi:10.1007/s12562-020-01403-7

Cited by 13 publications

(7 citation statements)

References 96 publications

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“…Furthermore, garlic is also rich in different bioactive compounds like allicin, glutathione diallyl sulfides [ 24 ] and important minerals (selenium, manganese and zinc) which encourage its consumption. Pre-treatment with garlic significantly reduced levels of ROS, lipid peroxidation and DNA damage, and thus enhanced the antioxidant system [ 11 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

et al. 2021

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In our study, Allium subhirsutum L. (AS) was investigated to assess its phenolic profile and bioactive molecules including flavonoids and organosulfur compounds. The antioxidant potential of AS and wound healing activity were addressed using skin wound healing and oxidative stress and inflammation marker estimation in rat models. Phytochemical and antiradical activities of AS extract (ASE) and oil (ASO) were studied. The rats were randomly assigned to four groups: group I served as a control and was treated with simple ointment base, group II was treated with ASE ointment, group III was treated with ASO ointment and group IV (reference group; Ref) was treated with a reference drug “Cytolcentella® cream”. Phytochemical screening showed that total phenols (215 ± 3.5 mg GAE/g) and flavonoids (172.4 ± 3.1 mg QE/g) were higher in the ASO than the ASE group. The results of the antioxidant properties showed that ASO exhibited the highest DPPH free radical scavenging potential (IC50 = 0.136 ± 0.07 mg/mL), FRAP test (IC50 = 0.013 ± 0.006 mg/mL), ABTS test (IC50 = 0.52 ± 0.03 mg/mL) and total antioxidant capacity (IC50 = 0.34 ± 0.06 mg/mL). In the wound healing study, topical application of ASO performed the fastest wound-repairing process estimated by a chromatic study, percentage wound closure, fibrinogen level and oxidative damage status, as compared to ASE, the Cytolcentella reference drug and the untreated rats. The use of AS extract and oil were also associated with the attenuation of oxidative stress damage in the wound-healing treated rats. Overall, the results provided that AS, particularly ASO, has a potential medicinal value to act as effective skin wound healing agent.

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Section: Introductionmentioning

confidence: 99%

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

et al. 2021

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“…are shown in Table 1. Similar to studies testing phytogenics from Lamiaceae family origin, the evaluation of the supplementation of phytogenics derived from Allium sp., also focuses on few immune markers in skin mucus (88,93), histopathological observations or some inflammatory and oxidative markers in gills (89,96) and intestine (90,(94)(95)(96)102), or incomplete microbiological examination that lacks in-depth the functional interpretation of their mode of action at cellular level (87,90,92).…”

Section: Effect Of Dietary Organosulfur Compounds Upon Fish Mucosal Immunitymentioning

confidence: 99%

Phytogenic Bioactive Compounds Shape Fish Mucosal Immunity

et al. 2021

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Aquaculture growth will unavoidably involve the implementation of innovative and sustainable production strategies, being functional feeds among the most promising ones. A wide spectrum of phytogenics, particularly those containing terpenes and organosulfur compounds, are increasingly studied in aquafeeds, due to their growth promoting, antimicrobial, immunostimulant, antioxidant, anti-inflammatory and sedative properties. This trend relies on the importance of the mucosal barrier in the fish defense. Establishing the phytogenics’ mode of action in mucosal tissues is of importance for further use and safe administration. Although the impact of phytogenics upon fish mucosal immunity has been extensively approached, most of the studies fail in addressing the mechanisms underlying their pharmacological effects. Unstandardized testing as an extended practice also questions the reproducibility and safety of such studies, limiting the use of phytogenics at commercial scale. The information presented herein provides insight on the fish mucosal immune responses to phytogenics, suggesting their mode of action, and ultimately encouraging the practice of reliable and reproducible research for novel feed additives for aquafeeds. For proper screening, characterization and optimization of their mode of action, we encourage the evaluation of purified compounds using in vitro systems before moving forward to in vivo trials. The formulation of additives with combinations of compounds previously characterized is recommended to avoid bacterial resistance. To improve the delivery of phytogenics and overcome limitations associated to compounds volatility and susceptibility to degradation, the use of encapsulation is advisable. Besides, newer approaches and dedicated methodologies are needed to elucidate the phytogenics pharmacokinetics and mode of action in depth.

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“…Volcanic dust in the atmosphere is also an important source of TiO 2 -NPs (Buffle, 2006 andHandy, et al, 2008b). Upon exposure, the concentrations of different types of nanoparticles were recorded much higher in 2 tissues of aquatic animals than the normal permissible concentrations (Asghar et al 2015;Khan et al 2018;Khan et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Study of Some Toxicological Aspects of Titanium Dioxide Nanoparticles Through Oxidative Stress, Genotoxicity, and Histopathology in Tilapia, Oreochromis mossambicus

et al. 2022

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Extensive use of nanotechnology in multiple commodities is raising concern about nanotoxicity and particularly.Particularly, many studies reported the health hazardous effects of titanium dioxide nanoparticles (TiO 2 -NPs). Study focuses on toxicity and accumulation of TiO 2 -NPs in tilapia (Oreochromis mossambicus). For this purpose, Tilapia were kept in water tanks, acclimatized for fourteen days, and treated with different doses of TiO 2 nanoparticles 0, 0.5, 1.0, and 1.5 mg TiO2-NPs /L. Results revealed an increase in accumulation of TiO 2 -NPs with an increase in doses.Moreover, with higher dose (1.5 mg /L) gills had maximum levels compared to muscles and liver tissues whereas other doses showed different accumulation patterns. A significantly higher concentration of catalase, glutathione, and lipid peroxidation was recorded in gills (p<0.05) and superoxide dismutase in the liver. Characteristics like thickening and fusion in lamellae, rupturing of filaments and hyperplasia of gills were also recorded. The phenomenon of increased necrosis and apoptosis in the liver was also noticed with increasing concentration of TiO 2 -NPs along with formation of sinusoid spaces and condensed nuclear bodies. Elevated values of olive tail movement and % tail DNA were also noticed with increased concentration of TiO 2 -NPs. This study concluded that TiO 2 -NPs produced oxidative stress by accumulation in soft tissues and induced pathology and genotoxicity.

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The role of garlic oil in the amelioration of oxidative stress and tissue damage in rohu Labeo rohita treated with silver nanoparticles

Cited by 13 publications

References 96 publications

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

Phytogenic Bioactive Compounds Shape Fish Mucosal Immunity

Study of Some Toxicological Aspects of Titanium Dioxide Nanoparticles Through Oxidative Stress, Genotoxicity, and Histopathology in Tilapia, Oreochromis mossambicus

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