The Role of Gene Polymorphisms of the Renin-Angiotensin System in the Formation of Cardiovascular Pathology

Levitskiy, Sergey N.; Pervukhina, Ol’ga; Bebyakova, Natal’ya A.

doi:10.17238/issn2308-3174.2016.4.30

Cited by 6 publications

(3 citation statements)

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“…Additionally, other AGT promoter polymorphisms, including G217A and A-6G, were significantly associated with stroke in patients with atrial fibrillation (38). At the same time, a meta-analysis of epidemiological findings revealed no correlation between polymorphism of M235T with hypertrophic cardiomyopathy in European populations, while in Asian populations, there has been an association with the sporadic form of hypertrophic cardiomyopathy (35).…”

Section: Discussionmentioning

confidence: 98%

“…The Т174М (rs4762) polymorphism is characterized by a replacement of threonine with methionine at position 174 in the peptide chain, which is caused by a point replacement of cytosine with thymine at position 521 of the AGT gene (C521T). The М235Т (rs699) polymorphism is a replacement of methionine with threonine at position 235 of the peptide chain, which is caused by a point replacement of thymine with cytosine at position 704 of the AGT gene (Т704С) (35,36). .…”

Section: Discussionmentioning

confidence: 99%

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Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

2019

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BackgroundChronic obstructive pulmonary disease (COPD) continues to cause a heavy health and economic burden in the Europe and around the world. Arterial hypertension (AH) is considered as one of the principal COPD-associated comorbidi-ties. However, no data for association between gene polymorphism and AH in patients with COPD in Ukraine have ever been internationally published. We assessed the genotype and allele frequencies of angiotensinogen (AGT) M235T polymorphisms in patients with COPD and comorbid AH.MethodsThe study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH) and Group 3 (28 individuals with COPD and AH). The control group consisted of 20 healthy subjects. M/T genotypes of AGT were determined by polymerase chain reaction amplification.ResultsThe results of the study have not demonstrated any significant impact of alleles of AGT genes on the occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations. At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above-mentioned diseases.ConclusionsThe study that we have conducted suggests that the presence of T allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous states may increase the risk for AH in patients with COPD.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

2019

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“…30 Polymorphisms of the genes encoding RAAS components were found in different populations. [31][32][33] The angiotensinogen gene (AGT) is localised on the long arm of chromosome 1 in 1q42-q43 locus and contains 5 exons. In the AGT gene, the best studied variants include the polymorphic M235T and T174M variants.…”

Section: Discussionmentioning

confidence: 99%

AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

Maksiv¹,

Krynytska²

2021

Bangladesh Med Res Counc Bull

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Background: Chronic obstructive pulmonary disease (COPD) represents an important public health challenge. It is a major cause of chronic morbidity and mortality throughout the world. Arterial hypertension (AH) is considered one of the principal COPD-associated comorbidities. Objective: The study was aimed to assess the role of angiotensinogen (AGT) gene polymorphism in occurrence of AH in patients with COPD. Methods: The study was conducted among 96 patients of them, Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of AGT were determined by polymerase chain reaction amplification. Plasma AGT activity was determined photometrically by a commercially available kit. Results: The results of the study have not demonstrated any significant impact of alleles of AGT genes on occurrence of such disease as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations (OR=0.90, OR=0.71 and OR=0.56, respectively). At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above mentioned disease (OR=1.11, OR=1.4 and OR=1.79, respectively). Conclusion: The study suggests that the presence of Т allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous state may increase the risk for AH in patients with COPD. Bangladesh Med Res Counc Bull 2020; 46(3): 176-183

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Clinical and genetic predictors of preeclampsia in the presence of gestational diabetes mellitus

Putilova¹,

Deryabina²,

Tretyakova³

2020

Ross. vestn. akush.-ginekol.

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The Role of Gene Polymorphisms of the Renin-Angiotensin System in the Formation of Cardiovascular Pathology

Cited by 6 publications

References 0 publications

Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

Clinical and genetic predictors of preeclampsia in the presence of gestational diabetes mellitus

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