The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review

Smail, Harem Othman

doi:10.14421/biomedich.2020.92.57-64

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…ACE2 receptors on the pulmonary endothelium serve as the main ingress point for Coronavirus. Several previous animal models have revealed a rise in ACE2 activity in the male or ovariectomized model, hinting at a sex hormone influence (Smail, 2023). Interestingly, the ACE2 receptor gene is also found on the X chromosome and has some generous causes that increase mortality and morbidity in men, such as (smoking) Usually, the smoking rate is much higher in men than in women (Gebhard et al,2020, Walter et al,2020.…”

Section: Discussionmentioning

confidence: 99%

Level of D-dimer And C- Reactive Protein among Covid-19 Patients in Relation to Different Ages And Genders

Abdullah,

Smail,

Rahim

et al. 2023

JDU

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coronavirus disease of 2019 (COVID-19) is a new infectious disease spreading worldwide rapidly. COVID-19 has been associated with a risk of thrombosis, which an increase in the level of D-dimer can detect. D-dimer is a small fragment of protein present in the blood after blood clot degradation. This research aimed to evaluate the level of D-Dimer and C-reactive protein in COVID-19 patients and ascertain the relation of these markers with age and gender. From December 2020 to January 2021, patients with laboratory reports of Covid-19 were retrospectively enrolled in different hospitals and private laboratories. We collected 253 cases of the D-dimer test for different ages and genders and 204 cases of C-reactive protein test with D-dimer to detect the severity of the disease. An increased level of Ddimer of more than 0.5 mcg/ml was reported in 105 patients (41.5%). According to gender, 43.7% of males and 38.79% of females have elevated D-dimer levels. In patients with COVID-19, D-dimer levels greater than 0.5mcg/mL could accurately predict in-hospital morbidity and mortality. Therefore, D-dimer has been proposed as a possible early and effective marker for improved management of COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Level of D-dimer And C- Reactive Protein among Covid-19 Patients in Relation to Different Ages And Genders

Abdullah,

Smail,

Rahim

et al. 2023

JDU

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“…Furthermore, gene therapy has been widely used to treat cancer, cardiovascular disease, infections, decreased metabolic function, lymphatic diseases, radiation-induced injuries, and post-surgical therapy. Gene therapy can also be a solution to treat diabetes mellitus, although the efficacy and safety of this therapy is still a problem [17], [18], [19].…”

Section: Introductionmentioning

confidence: 99%

Deletion of the RNLS Gene using CRISPR/Cas9 as Pancreatic Cell β Protection against Autoimmune and ER Stress for Type 1 Diabetes Mellitus

Baraja

Sunarto

Adji

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Type 1 diabetes mellitus (T1DM) is a chronic disease in children which is usually caused by autoimmunity that damages pancreatic a and b cells which have functions as blood glucose regulators. Some studies stated that Renalase (RNLS) gene deletion will protect these b cells from autoimmune reactions and Endoplasmic Reticulum (ER) stress. RNLS deletion by genome editing Clustered Regular interspersed Short Palindromic Repeats-CRISPR-related (CRISPR/Cas9) is believed to have the potential to be a therapy for T1DM Patients. AIM: This research was conducted to know the potential of RNLS deletion using the CRISPR/Cas9 as an effective therapy and whether it has a permanent effect on T1DM patients. METHODS: The method applied in this research summarized articles by analyzing the titles and abstracts of various predetermined keywords. In this case, the author chose a full-text article published within the past 10 years by prioritizing searches in the last 5 years through PubMed, Google Scholar, Science Direct, Cochrane, American Diabetes Association, and official guidelines from IDAI. RESULTS: RNLS deletion using CRISPR/Cas9 in mice weakened the response of polyclonal -cell-reactive CD8+ T cells and disrupted the immune recognition to cells so that autoimmune killing did occur. In addition, such deletion prevents RNLS ER stress by increasing the threshold, triggering the unfolded protein response so that ER stress is difficult to occur. RNLS mutations in b cells also increase b cell survivability to oxidative stress. CONCLUSION: b cells RNLS deletion by genome editing CRISPR/Cas9 is effective in protecting b cells from autoimmune reactions and RE stress. However, further research is needed to determine the side effects and safety of its use.

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Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

Khazaei

Niromand

et al. 2022

Journal of Drug Targeting

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The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review

Cited by 3 publications

References 70 publications

Level of D-dimer And C- Reactive Protein among Covid-19 Patients in Relation to Different Ages And Genders

Level of D-dimer And C- Reactive Protein among Covid-19 Patients in Relation to Different Ages And Genders

Deletion of the RNLS Gene using CRISPR/Cas9 as Pancreatic Cell β Protection against Autoimmune and ER Stress for Type 1 Diabetes Mellitus

Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

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