The role of growth factors in extraction wound healing

Stojanović, Simona; Tijanić, Miloš; Jovanović, Goran; Spasić, Milan; Stojković, Branislava; Petrovic, B Milica; Dencic, Tijana

doi:10.5937/asn1572524s

Cited by 2 publications

(3 citation statements)

References 49 publications

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“…Lokalna upotreba baznog fibroblastnog faktora rasta bFGF dovodi do stvaranja novih ćelija periodontalnog ligamenta i kolagenih vlakana koja se direktno vezuju za cement i kost, smanjujući tako ankilozu i resorpciju korena zuba kod kojih je urađena odložena replantacija [35][36][37] .…”

Section: Treatment Of Teeth With Completed Root Developmentunclassified

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Permanent tooth avulsion in children and adults: Therapeutic options for longer survival

Stojanović¹,

Tijanić²,

Burić³

et al. 2021

Acta stomatologica Naissi

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Introduction: Permanent tooth avulsions (traumatic extraction; total luxation) are one ofthe most severe permanent tooth injuries and can occur as single injuries or associated with other dental injuries or injuries to the face and jaws region. They are defined as the luxation of teeth from the alveoli with complete rupture of periodontal fibres, or with one part attached to the rootcementum and the other to the alveolar bone, thus compromising the dental pulp, root cementum,and alveolar bone. The high prevalence and numerous negative consequences on the stomatognathic systems they have suggest permanent tooth avulsions should be regarded as an important public health problem. The aim: is to point out the therapeutic possibilities of permanent tooth avulsion that can ensure their longer survival in the oral cavity. Conclusion: The treatment strategy for avulsed permanent teeth is always based on limiting root canal infection and periradicular inflammation, shifting the balance from unfavourable (replacement resorption) to favourable (periodontal) healing. The success of therapy and periodontal healing depend on the duration and conditions of extraoral tooth preservation, the degree of damage to the periodontal ligament, and the condition of the pulp.

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Section: Treatment Of Teeth With Completed Root Developmentunclassified

“…Topical use of the basic fibroblast growth factor (bFGF) leads to the formation of new periodontal ligament cells and collagen fibres that bind directly to the cementum and bone, thus reducing ankylosis and the resorption of tooth roots in which delayed replantation has been performed [35][36][37] .…”

Section: Zaključakmentioning

confidence: 99%

Permanent tooth avulsion in children and adults: Therapeutic options for longer survival

Stojanović¹,

Tijanić²,

Burić³

et al. 2021

Acta stomatologica Naissi

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show abstract

“…In this phase, the inflammatory response results in phagocytosis of debris and dead or injured cells. During the phase transition from inflammation to proliferation, growth factors and cytokines such as epidermal growth factor (EGF), transforming growth factor beta (TGF‐β), and platelet‐derived growth factor (PDGF) are released (Barrientos et al, 2008; Stojanovic et al, 1996; Werner & Grose, 2017). These molecules signal cellular migration, recruitment and proliferation, processes that are essential for effective tissue remodeling, vascularization, and epithelialization (Ellis et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care

et al. 2020

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There is a growing clinical demand in the wound care market to treat chronic wounds such as diabetic foot ulcers. Advanced cell and tissue-based products (CTPs) are often used to address challenging chronic wounds where healing has stalled. These products contain active biologics such as growth factors and cytokines as well as structural components that support and stimulate cell growth and assist in tissue regeneration. This study addresses the in vitro biologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro-inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF-β, IL-8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the reduction of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. This study findings are consistent with the clinical benefits previously published for DAMA and other CTPs in chronic wounds suggesting that the introduction of DAMA to nonhealing, complex wounds helps to improve the wound milieu by providing essential structural components, cytokines, and growth factors to create an appropriate environment for wound healing.

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The role of growth factors in extraction wound healing

Cited by 2 publications

References 49 publications

Permanent tooth avulsion in children and adults: Therapeutic options for longer survival

Permanent tooth avulsion in children and adults: Therapeutic options for longer survival

Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care

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