The role of gut microbiome in inflammatory skin disorders: a systematic review

Widhiati, Suci; Purnomosari, Dewajani; Wibawa, Tri; Soebono, Hardyanto

doi:10.4081/dr.2022.9188

Cited by 22 publications

(24 citation statements)

References 85 publications

(162 reference statements)

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“…As the gut microbiome has emerged as the major regulator of the gut-skin axis, recent studies on the gut microbiota and patients with inflammatory skin diseases, including AD, have been conducted [1][2][3][4][5]. The gut microbiota is a large collection of microorganisms in the human gastrointestinal (GI) tract.…”

Section: Introductionmentioning

confidence: 99%

“…The importance of gut microbiota diversity has been highlighted in recent studies examining the association between the gut microbiota and chronic inflammatory skin diseases, such as acne, rosacea, and psoriasis, as well as AD [3,4]. A recent systematic literature review that analyzed the association of inflammatory skin diseases with imbalance of the gut microbiota found that there were consistently significant differences in the gut microbiota between healthy individuals and patients with acne vulgaris, psoriasis, and chronic urticaria [5]. However, it was reported that studies on AD have shown conflicting results [5].…”

Section: Introductionmentioning

confidence: 99%

“…A recent systematic literature review that analyzed the association of inflammatory skin diseases with imbalance of the gut microbiota found that there were consistently significant differences in the gut microbiota between healthy individuals and patients with acne vulgaris, psoriasis, and chronic urticaria [5]. However, it was reported that studies on AD have shown conflicting results [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms

Han

Kwon

Yeom

et al. 2022

JCM

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(1) Background: Atopic dermatitis (AD) is a multifactorial chronic allergic skin disease. Gastrointestinal (GI) functions have been suggested to be associated with its incidence or severity. As modulators of the gut–skin axis, gut microbes might affect the pathophysiology of AD. (2) Methods: We divided a cohort of patients with AD according to their GI symptoms as follows: AD with epigastric fullness (ADwEF), AD with epigastric rigidity (ADwER), and AD without GI symptoms (ADw/oGI). The gut microbial profiles were analyzed using 16S rRNA amplicon sequencing. (3) Results: The microbiota of the ADwER group showed low diversity indices in richness and evenness and formed a separate cluster to the other groups. In the ADwER group, the proportion of Bacteroides increased, while that of Prevotella decreased; functional pathways related to phosphotransferase systems were not abundant relative to those in the ADw/oGI group. Taken together, patients with AD with GI symptoms have a different microbiome from patients with simple AD. (4) Conclusions: In an exploratory study aimed at evaluating the relationship between AD and GI symptoms, the gut microbiome in patients with AD with GI symptoms differed from that in patients with simple AD, and this result could serve as a basis for further gut–skin axis studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms

Han

Kwon

Yeom

et al. 2022

JCM

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“…Anti-inflammatory bacteria such as Akkermansia muciniphila, Faecalibacterium prausnitzii, Clostridium leptum, genus Lactobacillus and Bifidobacterium have shown to protect from allergic and inflammatory diseases [ 35 ]. Anti-inflammatory bacteria might protect against CSU through the induction of Treg cells [ 76 ]. Lastly, some studies have shown the beneficial impact of probiotics in CSU patients.…”

Section: Gut Microbiome In Patients With Chronic Spontaneous Urticariamentioning

confidence: 99%

Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data

Krišto¹,

Lugović-Mihić²,

Muñoz

et al. 2023

Life

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Recent studies have linked gut microorganism composition and chronic urticaria (CU); however, the underlying mechanisms responsible for this connection are unknown. Since the human immune system is in homeostasis with microbiota, and the composition of the microbiome regulates the development and function of the immune system, it is likely that an alteration of microbiota components (a dysbiosis) could influence the course of chronic spontaneous urticaria (CSU), including disease severity, patient quality of life and treatment outcome. To date, several studies have identified changes in the gut microbiota composition of patients with CSU, though only a few have exhibited metabolic abnormalities associated with gut dysbiosis. The studies on CSU patients predominantly showed that the relative abundance of beneficial bacteria was decreased (Firmicutes and Bacteroides), while that of opportunistic bacteria was increased (Enterobacteria and Proteobacteria). In addition, serum metabolome analysis revealed that gut microbiota-associated alterations in unsaturated fatty acids and the butanoate metabolism pathway may play a role in CSU. These findings are potentially associated with inflammation mediated by the imbalance of Th1/Th2/Th17 cytokines, which might contribute to CSU pathogenesis. Further research in this field could improve clinical, diagnostic, and therapeutic approaches to patients with CSU. By applying new knowledge on gut microbial communities and metabolomics, future CSU therapies could modify the microbiota composition using agents such as probiotics or other similar agents, which, in combination with current standard therapies, could hopefully lead to a reduction in symptoms and an improved quality of life for CSU patients.

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“… 9 , 10 Several studies examining differences in the composition of the intestinal microbiota between psoriasis patients and healthy controls have suggested that disorders of the intestinal microbiota may be closely related to the development of psoriasis. 11 – 13 Germ-free (GF) mice develop more severe psoriasis-like skin inflammation than conventional mice due to enhanced Th17 responses, indicating that the intestinal microbiota may indeed be crucial in the progression of psoriasis. 14 Moreover, sPLA2-IIA was contributed to the shaping of the gut microbiota and Pla2g2a –/– mice showed an altered intestinal microbiota which regulated the pathogenesis of psoriasis and skin carcinogenesis through co-housing experiment.…”

Section: Introductionmentioning

confidence: 99%

Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism

Zhao

Wang

et al. 2023

Sig Transduct Target Ther

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The intestinal microbiota has been associated with host immunity as well as psoriasis; however, the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically. Here, we sought to examine its role and mechanism of action in the pathogenesis of psoriasis. We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota. We performed co-housing and fecal microbial transplantation (FMT) experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms, including increasing the infiltration and differentiation of Th17, and increased the abundance of Prevotella, while decreasing that of Parabacteroides distasonis, in the colon. These alterations affected fatty acid metabolism, increasing the abundance of oleic and stearic acids. Meanwhile, gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod (IMQ)-induced psoriasis-like mice. Indeed, administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo, as well as increased the secretion of IL-23 by stimulating DCs in vitro. At last, we found that, treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota, including the decrease of Prevotella and increase of Parabacteroides distasonis. Overall, our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice, suggesting a new target for the clinical diagnosis and treatment of psoriasis.

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The role of gut microbiome in inflammatory skin disorders: a systematic review

Cited by 22 publications

References 85 publications

Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms

Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms

Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data

Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism

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