The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke

Zeng, Meiqin; Peng, Man; Liang, Junchao; Sun, Haitao

doi:10.1007/s12035-023-03512-7

Cited by 6 publications

(4 citation statements)

References 200 publications

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“…Increased LPS contents could impair the intestinal epithelial barrier (IEB) (Guo et al, 2015 ) and blood–brain barrier (BBB) (Peng et al, 2021 ). Recent studies have revealed that gut barrier integrity and BBB are involved in the influence of GM on IS (Gwak and Chang, 2021 ; Zeng et al, 2023 ). A new study found that intraperitoneal injection of LPS after stroke exhibited intestinal morphology damage, decreased expression of tight-junction proteins associated with the BBB, and more neuronal loss, and these changes were consistent with stroke mice transplanted with gut microbiota associated with post-stroke cognitive impairment (Wang et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Zhu,

Li,

Chu

et al. 2024

Front. Microbiol.

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BackgroundIncreasing research has implicated the possible effect of gut microbiota (GM) on the prognosis of ischemic stroke (IS). However, the precise causal relationship between GM and functional outcomes after IS remains unestablished.MethodsData on 211 GM taxa from the MiBioGen consortium and data on prognosis of IS from the Genetics of Ischemic Stroke Functional Outcome (GISCOME) network were utilized as summary-level data of exposure and outcome. Four kinds of Mendelian randomization (MR) methods were carried out to ascertain the causal effect of GM on functional outcomes following IS. A reverse MR analysis was performed on the positive taxa identified in the forward MR analysis to determine the direction of causation. In addition, we conducted a comparative MR analysis without adjusting the baseline National Institute of Health Stroke Scale (NIHSS) of post-stroke functional outcomes to enhance confidence of the results obtained in the main analysis.ResultsFour taxa were identified to be related to stroke prognosis in both main and comparative analyses. Specifically, genus Ruminococcaceae UCG005 and the Eubacterium oxidoreducens group showed significantly negative effects on stroke prognosis, while the genus Lachnospiraceae NK4A136 group and Lachnospiraceae UCG004 showed protective effects against stroke prognosis. The reverse MR analysis did not support a causal role of stroke prognosis in GM. No evidence of heterogeneity, horizontal pleiotropy, and outliers was found.ConclusionThis MR study provided evidence that genetically predicted GM had a causal link with post-stroke outcomes. Specific gut microbiota taxa associated with IS prognosis were identified, which may be helpful to clarify the pathogenesis of ischemic stroke and making treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Zhu,

Li,

Chu

et al. 2024

Front. Microbiol.

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“…They release factors such as NO and VEGF, impacting vasodilation and oedema. Astrocyte–endothelial cell interactions induce specific phenotypes crucial for maintaining BBB homeostasis, especially during neuroinflammation following IS [ 37 , 65 ].…”

Section: Blood–brain Barrier Disruptionmentioning

confidence: 99%

“…The endothelial glycocalyx layer and the expression of leukocyte adhesion molecules further modulate the BBB permeability. Equipped with a comprehensive molecular transport system, the BBB maintains brain homeostasis by facilitating essential nutrient transport and preventing toxic compound accumulation [ 37 , 65 ].…”

Section: Blood–brain Barrier Disruptionmentioning

confidence: 99%

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Briones-Valdivieso,

Briones,

Orellana-Urzúa

et al. 2024

Biomedicines

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Stroke is a major contributor to global mortality and disability. While reperfusion is essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, a paradoxical injury primarily caused by oxidative stress, inflammation, and blood–brain barrier disruption. An oxidative burst inflicts marked cellular damage, ranging from alterations in mitochondrial function to lipid peroxidation and the activation of intricate signalling pathways that can even lead to cell death. Thus, given the pivotal role of oxidative stress in the mechanisms of cerebral ischemia-reperfusion injury, the reinforcement of the antioxidant defence system has been proposed as a protective approach. Although this strategy has proven to be successful in experimental models, its translation into clinical practice has yielded inconsistent results. However, it should be considered that the availability of numerous antioxidant molecules with a wide range of chemical properties can affect the extent of injury; several groups of antioxidant molecules, including polyphenols, carotenoids, and vitamins, among other antioxidant compounds, can mitigate this damage by intervening in multiple signalling pathways at various stages. Multiple clinical trials have previously been conducted to evaluate these properties using melatonin, acetyl-L-carnitine, chrysanthemum extract, edaravone dexborneol, saffron, coenzyme Q10, and oleoylethanolamide, among other treatments. Therefore, multi-antioxidant therapy emerges as a promising novel therapeutic option due to the potential synergistic effect provided by the simultaneous roles of the individual compounds.

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“…However, only a few experimental studies have been performed on stroke models to observe the BBB by altering the structure of gut microbiota, which warrant further exploration. Therefore, in order to provide a novel mechanism for stroke and highlight new insights into BBB modification as a stroke intervention, this review summarizes existing evidence of the relationship between gut microbiota and BBB integrity and discusses the mechanisms of gut microbiota on BBB dysfunction and its role in stroke (17).…”

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confidence: 99%

Gut Microbiota. Neuropolen for Recovery after A Ischemic Stroke

GIURGIU,

COJOCARU

2023

AnnalsARSciBio

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Background The brain possesses an extraordinary ability to heal itself after a stroke. This ability is known as neuroplasticity. The relationship between the gut microbiota and stroke is recent, with early studies dating from 2013. Recent studies support that gut microbiota is associated with ischemic stroke through the gut-brain axis, thereby modulating stroke pathogenesis. Objectives Gut dysbiosis, defined as alterations to the gut microbial communities has been proposed in stroke. To determine whether Neuropolen can be a potential treatment for recovery after a stroke. Material and methods The 2-way communication between the gut and the brain, which involves the brain, the gut microbiota, and the intestinal tissue, has been suggested as a key component of stroke outcome. To arrive at these observations, authors examined how Neuropolen and diet solve disabilities. Results The gut microbiota can increase the risk of a cerebrovascular event, playing a role in the onset of stroke. Conversely, stroke can induce dysbiosis of the gut microbiota. We found that Neuropolen may be important for functional recovery after a stroke. Neuropolen that may help minimize the degree of complications, stimulation enhances plasticity of the brain, in which noninjured parts of the brain can pick up the job of the injured brain areas. Conclusion In this presentation, authors describe the role of the gut microbiota, microbiome and microbiota-derived metabolites in stroke, and their use as therapeutic targets. Neuropolen may be a potential therapy for recovery after a stroke, it can quickly feed oxygen to the brain and protect brain cells.

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The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke

Cited by 6 publications

References 200 publications

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Gut Microbiota. Neuropolen for Recovery after A Ischemic Stroke

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