The role of Helicobacter Pylori and laryngopharyngeal reflux in recurrent tonsillitis

Singh, Gautam; War, Gabriella Yvette; Shukla, Shailja; Kaur, Ravinder; Malhotra, Sonali; Kumar, Sunil

doi:10.1016/j.ijporl.2020.110376

Cited by 6 publications

(3 citation statements)

References 53 publications

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“…Interestingly, this mechanism, along with reflux-induced lung injury and hyper-responsiveness triggered by lower airway aspiration of refluxates, compose the most probable pathophysiologic mechanisms by which reflux disease can cause chronic or recurrent lower respiratory tract disease or aggravate asthma [ 20 , 57 ]. Another controversial theory postulates a supplemental contributing role for Helicobacter pylori [ 24 , 42 , 50 , 86 ]. Mucosa-associated lymphoid tissue in the Waldeyer ring is similar to lymphoid tissue of the stomach, which can be very favorable for the survival of H. pylori that further promotes inflammation, and also contributes to the reactive hyperplasia of the lymphatic tissue in the nasopharynx and tonsils [ 35 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?

Sofokleous

Παπαδοπούλου

Giotakis

et al. 2023

JCM

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Background: Laryngopharyngeal reflux may affect people of any age; still, most of the accumulated knowledge concerns adults, and evidence regarding pediatric populations remains relatively restricted. This study aims to review the most recent and emerging aspects of pediatric laryngopharyngeal reflux from the last ten years. It also attempts to identify gaps in knowledge and highlight discrepancies that future research should urgently address. Methods: An electronic search of the MEDLINE database was conducted, limited to January 2012 through December 2021. Non-English language articles, case reports, and studies that concerned a purely or predominantly adult population were excluded. The information from the articles with the most relevant contribution was initially categorized by theme and subsequently synthesized into a narrative form. Results: 86 articles were included, of which 27 were review articles, eight were surveys, and 51 were original articles. Our review systematically maps the research done in the last decade and provides an updated overview and the current state-of-the-art in this subject. Conclusions: Despite discrepancies and heterogeneity in accumulating research, evidence gathered so far endorses a need for refining an escalating multiparameter diagnostic approach. A step-wise therapeutic plan appears to be the most reasonable management approach, starting with behavioral changes for mild to moderate, uncomplicated cases and escalating to personalized pharmacotherapy options for severe or nonresponsive cases. Surgical options could be considered in the most severe cases when potentially life-threatening symptoms persist despite maximal medical therapy. Over the past decade, the amount of available evidence has been gradually increasing; however, its strength remains low. Several aspects remain markedly under-addressed, and further adequately powered, multicenter, controlled studies with uniformity in diagnostic procedures and criteria are urgently needed.

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Section: Resultsmentioning

confidence: 99%

Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?

Sofokleous

Παπαδοπούλου

Giotakis

et al. 2023

JCM

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“…pylori is a known pathogen of the gastric mucosa and infection caused by HP is a common and difficult-to-treat health problem. Since its discovery in 1983, it has been implicated in the pathology of duodenal ulcers, atrophic gastritis, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, and stomach cancer 3,7 . The affinity of the bacterium to lymphoid tissues may explain its presence in tonsillary and adenoid tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of Helicobacter pylori (HP) colonization may play a role in infection of tonsillary tissues. Numerous studies have reported an association between CT and HP colonization [2][3] .…”

Section: Introductionmentioning

confidence: 99%

Colonization of Helicobacter pylori in Tonsillectomy Materials

Gunizi¹,

Gunizi²

2022

jamp

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To detect the presence of Helicobacter pylori in tonsillar tissue, and to investigate the difference in Helicobacter pylori colonization in patients with tonsillary hypertrophy and chronic tonsillitis. One hundred twenty-two patients underwent tonsillectomy due to chronic tonsillitis. or tonsillary hypertrophy was included in our retrospective study. The tonsillectomy materials of the patients were stained with the Giemsa stain and evaluated under light microscopy. The data obtained in the study were evaluated statistically and results with a p-value of <0.05 were accepted as significant. The mean age of the patients included in the study was 11.9 years. Ninety-three (76.2%) patients were in the pediatric age group, and 29 (23.8%) were adults. Fifty-five (45.1%) patients were female and 67 (54.9) were male. Eighty patients underwent tonsillectomy due to tonsillary hypertrophy and 42 due to chronic tonsillitis. In our study, the presence of Helicobacter pylori was detected in 21 (17.2%) patients. The presence of Helicobacter pylori colonization in patients with chronic tonsillitis and tonsillary hypertrophy indicates that tonsils are an extra-stomach reservoir for Helicobacter pylori.

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