The Role of Hemoglobin Variant Replacement in Retinopathy of Prematurity

Podraza, Wojciech; Podraza, Hanna; Jezierska, K; Szwed, Joanna; Modrzejewska, Monika; Rudnicki, Jacek; Kordek, Agnieszka; Domek, Hanna

doi:10.1007/s12098-011-0460-7

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Newborn's hemoglobin is predominantly fetal hemoglobin (HbF), with a higher affinity for oxygen than adult hemoglobin [8]. Transfusions are performed with adult blood containing almost 100% hemoglobin A (HbA), leading to a replacement of the physiological content of HbF by HbA, and a shift to the right in the oxygen-hemoglobin dissociation curve [46]. A higher proportion of adult hemoglobin may lead to increased oxygen bioavailability, causing relative tissue hyperoxia [8].…”

Section: Discussionmentioning

confidence: 99%

Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Fevereiro-Martins

Santos

Marques-Neves

et al. 2023

IJMS

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The development of retinopathy of prematurity (ROP) may be influenced by anemia or a low fetal/adult hemoglobin ratio. We aimed to analyze the association between DNA methyltransferase 3 β (DNMT3B) (rs2424913), Methylenetetrahydrofolate reductase (MTHFR) (rs1801133), and lysine-specific histone demethylase 1A (KDM1A) (rs7548692) polymorphisms, erythrocyte parameters during the first week of life, and ROP. In total, 396 infants (gestational age < 32 weeks or birth weight < 1500 g) were evaluated clinically and hematologically. Genotyping was performed using a MicroChip DNA on a platform employing iPlex MassARRAY®. Multivariate regression was performed after determining risk factors for ROP using univariate regression. In the group of infants who developed ROP red blood cell distribution width (RDW), erythroblasts, and mean corpuscular volume (MCV) were higher, while mean hemoglobin and mean corpuscular hemoglobin concentration (MCHC) were lower; higher RDW was associated with KDM1A (AA), MTHFR (CC and CC + TT), KDM1A (AA) + MTHFR (CC), and KDM1A (AA) + DNMT3B (allele C); KDM1A (AA) + MTHFR (CC) were associated with higher RDW, erythroblasts, MCV, and mean corpuscular hemoglobin (MCH); higher MCV and MCH were also associated with KDM1A (AA) + MTHFR (CC) + DNMT3B (allele C). We concluded that the polymorphisms studied may influence susceptibility to ROP by modulating erythropoiesis and gene expression of the fetal/adult hemoglobin ratio.

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Section: Discussionmentioning

confidence: 99%

Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Fevereiro-Martins

Santos

Marques-Neves

et al. 2023

IJMS

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“…Advanced stage ROP may be associated with vision loss ranging from severe vision loss to full blindness. In the USA alone, 14,000 -16,000 infants have different stages of ROP, and more than 50,000 children worldwide are blind due to ROP [3] [4]. ROP is the most important global cause of visual impairment and blindness in premature infants [5].…”

Section: Introductionmentioning

confidence: 99%

“…Decreases occur in levels of haemoglobin (Hb), the protein that carries oxygen from the lungs to the tissues in the circulation, and in the haematocrit (Hct), for various reasons in infants with ROP, and these decreases may be an additional enhancing factor for VEGF secretion by increasing the retinal hypoxia in premature infants. The resulting cytokines are responsible for a destructive new vascularisation in the retina (Phase II ROP) [3]. Angiogenesis regulated by local release of proangiotic or angiogenic factors is a further critical step in the development pathological ROP [6].…”

Section: Introductionmentioning

confidence: 99%

Haemogram Parameters in the Development of Retinopathy of Prematurity

Akdogan¹,

Demirag²,

Varal³

et al. 2018

OJOph

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Purpose: Retinopathy of prematurity (ROP), an abnormal proliferation of retinal vessels in premature infants with low birth weight, develops due to many factors. This study investigated a possible correlation between haematological parameters and ROP development. Method: This study included 189 infants without ROP and 128 with ROP. All were born at 35 weeks' gestation or earlier, had a CBC drawn within 72 hours of birth, and had haemogram data for the first month. Haemoglobin (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), red cell distribution width (RDW), platelet counts (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) values were obtained from hospital data and retrospectively analysed. Results: The mean gestational age was 31 weeks and 29 weeks for the control and ROP groups, respectively; the mean birth weights were 1757 g and 1332 g, respectively. The ROP group's birth Hb, MCV and RDW were significantly lower than the control group (p < 0.001), whereas PLT and MPV were significantly higher (p < 0.001). The ROP group's Hb and PLT in the first month were significantly lower than the control group (p < 0.001), whereas RDW, MPV and PDW were significantly higher (p < 0.001). Conclusion: Premature infants with ROP had lower Hb and increased platelet, MPV and PDW in early postnatal life than infants without ROP. In the first month, when ROP develops, low PLT, PDW and Hb and high MPV could be indicators for ROP diagnosis, follow-up and treatment.

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Investigation of the effect of hemoglobin F and A levels on development of retinopathy of prematurity

Erdöl

Hacıoğlu

Kola

et al. 2017

Journal of American Association for Pediatric Ophthalmology and

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The Role of Hemoglobin Variant Replacement in Retinopathy of Prematurity

Abstract: The influence of the time factor on the statistical differences of MCV but not on the amount of transfused adult blood suggests that HbF - HbA replacement may play a role in ROP development.

Cited by 3 publications

References 21 publications

Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Haemogram Parameters in the Development of Retinopathy of Prematurity

Investigation of the effect of hemoglobin F and A levels on development of retinopathy of prematurity

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