The role of histopathological examination of the products of conception following first-trimester miscarriage in Erbil Maternity Hospital

Rashid, Payman Anwar

doi:10.15218/zjms.2017.054

Cited by 9 publications

(16 citation statements)

References 7 publications

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“…This finding is similar to reports from other studies. 13 14 These findings affirm the importance of routinely subjecting POCs to histopathological analysis as done in our center. Similarly, routine histopathlogical examination of POC is supported by the need to diagnose GTD which can be missed by other diagnostic methods.…”

Section: Discussionsupporting

confidence: 71%

“…This is similar to figures reported in other studies. 7 13 14 Other histopathological types were also seen with some having features with noteworthy clinical implications. Molar pregnancy constituted 9 (8.4%) of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…These and other age characteristics of the patients as reflected in Table 1 are comparable to findings in other studies. 13 14 19 The most diagnosed clinical condition on admission was incomplete abortion (48.6%), followed by complete abortion (29.0%), whereas the least was blighted ovum (0.9%). These findings are compared with the findings in other studies which reported incomplete abortion as the most common clinical condition at presentation.…”

Section: Discussionmentioning

confidence: 99%

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Routine histopathological analysis of the products of conception: Is there a value?

Ohayi

Onyishi

2020

Niger Med J

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Background: Spontaneous miscarriage is one of the two most common problems encountered in the first trimester of pregnancy. The value of histopathological analysis of products of conception (POC) obtained as a result is a source of controversy. The aim of this study is to evaluate the histopathological characteristics of suspected POC following the first-trimester miscarriage and determine the clinical value of such histopathological analyses. Materials and Methods: This is a retrospective study of the histopathological analysis of POC over a period from January 1 st to December 31 st of 2016 carried out in the histopathology laboratory of a university teaching hospital. Materials for the study were POC obtained following spontaneous first trimester miscarriage and received in our laboratory. Relevant information about the patients was retrieved from the laboratory database and matched with laboratory request forms and copies of histopathology reports archived in the laboratory. Obtained data were analyzed by simple statistical methods. Results: The most common clinical diagnosis on admission was incomplete abortion ( n = 52; 48.6%), followed by complete abortion ( n = 31; 29.0%); the lowest was blighted ovum ( n = 1; 0.9%). The predominant histopathological type was normal POC which constituted 73 cases (68.2%). Other histopathological diagnoses include hydatidiform mole (9, 8.4%) and no evidence of conception (15, 14%). Clinical and ultrasound evaluation missed 2 (22.2%) of the 9 histopathologically diagnosed hydatidiform moles. Conclusion: Histopathological analysis of POC helps to diagnose molar pregnancies and other conditions which can be missed by clinical and ultrasound evaluation. Therefore, routine histopathological analysis of POC is advocated.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Routine histopathological analysis of the products of conception: Is there a value?

Ohayi

Onyishi

2020

Niger Med J

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“…The products of conception which are passed during spontaneous abortion should be sent for histopathological examination and it should become a routine practice since it has got a great value not only in confirmation of pregnancy but also ruling out molar, ectopic pregnancies and most important is gestational trophoblastic diseases which needs further follow up [5]. concluded that histopathological examination of products of conceptions helps to diagnose important pathologies more effectively when compared to clinical examination so that mortality can be reduced [11,12].…”

Section: Discussionmentioning

confidence: 99%

Histomorphological study of chorionic villi in products of conception following first trimester abortions

Shilpa

Supreetha

Varshashree³

2018

Trop J Pathol Microbiol

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Background:The common problem which occurs in first trimester of pregnancy is miscarriage. Retained products of conception are commonly received specimen for histopathological examination. Apart from confirmation of pregnancy, a careful examination can provide some additional information about the cause or the conditions associated with abortion. Aim: 1. To study various histopathological changes occurring in chorionic villi in first trimester spontaneous abortions and to know the pathogenesis of abortions. Materials and methods: This was a cross sectional retrospective study carried out for over a period of 3 years from January 2015 to January 2018. A total of 235biopsies were obtained from patient with the diagnosis of the first trimester spontaneous abortions were included in this study. Results: In our study most common age group of the abortion was between 21-30 years (63%). Incomplete abortion was the commonest type of abortion (47.7%). Many dysmorphic features were observed in this study like hydropic change (67%), stromal fibrosis (62%), villi with reduced blood vessels (52.7%) and perivillous fibrin deposition. Other features seen were haemorrhage, fibrinoid degeneration, Aria Stella reaction and calcification. Reduced blood vessels in the villi had statistically significant association with stromal fibrosis and hydropic change which was <0.05. Conclusion: Cases with dysmorphic features as seen in the present study may be associated with certain chromosomal abnormalities. Such cases can not only be filtered for cytogenetic work up, but these features can also aid in counselling and planning of future pregnancies. Thus histopathological examination of abortus material is highly recommended.

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“…The legitimacy of routine histopathological assessment of uterine products of miscarriage is currently under debate [13][14][15][16][17][18][19][20][21][22][23]. Some authors opt for routine histopathological examination of gestational tissues as a necessary supplement to the miscarriage therapy because it enables treatment maintenance in the case of a proliferative pathology of the trophoblast [13][14][15][16][17][18][19]. An additional argument for histopathological examination is the possibility to obtain guidance on the necessity of further tests (e.g., genetic tests) and help make the final diagnosis in cases with pregnancy of unknown location [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the diagnostic value of histopathological examinations of miscarriage products after pharmacological induction of miscarriage and curettage

et al. 2019

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Objectives: For early miscarriage (pregnancy loss ≤ 12 weeks of gestation), two types of therapeutic treatment are offered (pharmacotherapy and curettage of the uterine cavity) depending on the presence and severity of clinical symptoms as well as patient choice. Our study aimed to assess the diagnostic value of the results of histopathological examinations of miscarriage products in relation to the administered treatments. Material and methods: 850 medical records from patients diagnosed with missed miscarriage or empty gestational sac were analyzed retrospectively. Patients underwent surgical treatment or pharmacotherapy. Inefficacy of pharmacotherapy resulted in subsequent curettage. The results of histopathology were evaluated for their diagnostic value and classified: subgroup 1-high value specimen (the studied specimen included fetal tissues, and villi), and subgroup 2-no-diagnosis (the studied specimen included maternal tissues, autolyzed tissues, blood clots). Data were compared with chi-squared test. Differences was considered significant at p < 0.05. Results: 1128 histopathological test results were analyzed; 569 (50.4%) were obtained during pharmacotherapy and 559 (49.6%) after curettage; out of the latter 497 after the initial pharmacotherapy and 62 after surgery. In the pharmacotherapy group, high value specimens comprised 231 cases (40.59%) while no diagnosis was obtained in 338 cases (59.4%). Considering specimens obtained in the course curettage, high value specimens were found in 364 cases (65.1%) while results that did not allow a diagnosis to be made were found in 195 cases (34.9%). Conclusions: Tissue specimens of high diagnostic value are obtained significantly more often during surgical treatment of miscarriage than during pharmacotherapy.

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The role of histopathological examination of the products of conception following first-trimester miscarriage in Erbil Maternity Hospital

Cited by 9 publications

References 7 publications

Routine histopathological analysis of the products of conception: Is there a value?

Routine histopathological analysis of the products of conception: Is there a value?

Histomorphological study of chorionic villi in products of conception following first trimester abortions

Comparison of the diagnostic value of histopathological examinations of miscarriage products after pharmacological induction of miscarriage and curettage

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