The role of homocysteine in seminal vesicles remodeling in rat

Ghoul, A.; Moudilou, Elara; Cherifi, M.; Zerrouk, Fouzia; Chaouad, B.; Moulahoum, Anissa; Aouichat-Bouguerra, S.; Othmani, Kaouther; Exbrayat, Jean-Marie; Benazzoug, Yasmina

doi:10.5603/fhc.a2017.0010

Cited by 6 publications

(5 citation statements)

References 52 publications

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“…Our result is in agreement with those reported by many previous studies that showed a methionine-enriched diet to induce a moderate Hhcy in different animal models (pig, gerbil, and rat) [27,29,30]. In the rat, a species known to be athero-resistant administration of a high dose of methionine (200 mg/ kg) for a long period (6 months) is necessary to induce Hhcy [31,32]. In our laboratory, a study published in 2019, reported for the first time a moderate Hhcy in Psammomys obesus; however, the Hhcy was induced by a high dose of methionine (300 mg/kg) administered for 4 weeks [13].…”

Section: Discussionsupporting

confidence: 93%

“…We first investigated the body weight of the animal every month during the 6 months of methionine administration and reported a significant decrease from the 2nd month to the end of the experiment. Similar results were reported by Ghoul and Zhou in rats and mice respectively [32,33]. However, the bodyweight seems to be not always affected in rats and gerbils by methionine-induced Hhcy [26,30,31] and it is plausible that the variations in the dose of methionine and duration of its administration may play a role.…”

Section: Discussionsupporting

confidence: 85%

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A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Zerrouk

Chaouad

Ghoul

et al. 2022

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Zerrouk

Chaouad

Ghoul

et al. 2022

Folia Histochem Cytobiol.

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“…[19][20][21] Several studies have found that HHcy is associated with the occurrence of fibrosis in different tissues of rats, such as myocardial fibrosis, intestinal fibrosis, and seminal vesicle fibrosis. [22][23][24] However, it is still unclear whether there is a similar association between HHcy and liver or LF. We conducted this crosssectional study to understand this correlation and found that Hcy was strongly correlated with the LSM values, as well as with the recognized serum biomarkers (AST/ ALT, APRI, FIB-4), used to evaluate the degree of LF.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Homocysteine is Associated with Liver Fibrosis in Health Check-Up Population

Lv¹,

Wang²,

Ji³

et al. 2021

IJGM

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Object Studies have shown a link between homocysteine (Hcy) and heart diseases, kidney diseases, cerebrovascular diseases, liver diseases, and other pathological conditions. However, the relationship between Hcy and liver fibrosis (LF) is unclear. Here, we studied the link between plasma Hcy concentration and LF. Methods We determined and recorded the plasma Hcy concentration, general biochemical parameters, and liver stiffness measurement (LSM) in 1582 subjects, followed by statistical data analyses. Results During different stages of LF, we found a considerable difference ( p <0.001 unless specified) in body mass index (BMI), sex, age, Hcy, the levels of alanine transaminase (ALT), gamma-glutamyl transpeptidase (GGT; P = 0.012), triglycerides (TG; P = 0.006), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBS), and platelet count (PLT). There was a strong association between the plasma Hcy concentration and the serum biomarkers of LF ( P <0.001) and the values of LSM ( P <0.001). Conclusion The plasma Hcy concentration was substantially different among different stages of LF. The higher the plasma Hcy concentration, the more evident was the degree of LF.

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“…Recently, it was shown that the content of fibrillar collagens in seminal vesicles was elevated in hyperhomocysteinemic rats. Hyperhomocysteinemia increased the expression of MMP-2, -3, -7 and -9 in seminal vesicles [ 185 ]. The accumulation of collagen and upregulation of MMPs in seminal vesicles might contribute to the physiological remodeling of seminal vesicles.…”

Section: Ev-associated Mmps: Roles In Immunosuppression and Reprodmentioning

confidence: 99%

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

Nawaz

Shah

Zanetti

et al. 2018

Cells

158

138

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Extracellular vesicles (EVs) are membrane enclosed micro- and nano-sized vesicles that are secreted from almost every species, ranging from prokaryotes to eukaryotes, and from almost every cell type studied so far. EVs contain repertoire of bioactive molecules such as proteins (including enzymes and transcriptional factors), lipids, carbohydrates and nucleic acids including DNA, coding and non-coding RNAs. The secreted EVs are taken up by neighboring cells where they release their content in recipient cells, or can sail through body fluids to reach distant organs. Since EVs transport bioactive cargo between cells, they have emerged as novel mediators of extra- and intercellular activities in local microenvironment and inter-organ communications distantly. Herein, we review the activities of EV-associated matrix-remodeling enzymes such as matrix metalloproteinases, heparanases, hyaluronidases, aggrecanases, and their regulators such as extracellular matrix metalloproteinase inducers and tissue inhibitors of metalloproteinases as novel means of matrix remodeling in physiological and pathological conditions. We discuss how such EVs act as novel mediators of extracellular matrix degradation to prepare a permissive environment for various pathological conditions such as cancer, cardiovascular diseases, arthritis and metabolic diseases. Additionally, the roles of EV-mediated matrix remodeling in tissue repair and their potential applications as organ therapies have been reviewed. Collectively, this knowledge could benefit the development of new approaches for tissue engineering.

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The role of homocysteine in seminal vesicles remodeling in rat

Abstract: Increased plasma concentration of Hcy accompanied by the accumulation of collagen and upregulation of MMPs in rat seminal vesicles might contribute to the remodeling of seminal vesicles.

Cited by 6 publications

References 52 publications

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Plasma Levels of Homocysteine is Associated with Liver Fibrosis in Health Check-Up Population

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

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