The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China

Zhang, Jing; Zhang, Deyu; Yang, Zhuo; Wang, Xiaobin; Wang, Danbo

doi:10.1186/s12885-020-06935-w

Cited by 16 publications

(18 citation statements)

References 32 publications

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“…Furthermore, the main HR-HPV genotypes detected among women with high-grade SILs (HSILs) in Shanghai were HPV 16, 58, 52, and 33 [ 28 ]; although, the HPV 52 and 33 infection rates in HSIL cases were significantly lower than those in cases of cervicitis/negative for intraepithelial ledion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US), and low-grade SILs (LSIL). However, a study in northeast China showed that women infected with HPV 16, 18, 31, and 33 had a high incidence of HSILs [ 29 ]. A limitation of this study is that there was no pathological data available (e.g., cervical cytology and histology results), and thus it is not possible to determine the relationships between HPV genotype and pathology.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Liu-ting

Qin

et al. 2022

Infect Agents Cancer

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Background Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China. Methods From January 2016 to May 2021, 41,140 women were tested for HPV infection. HPV genotyping included 15 high-risk HPV (HR-HPV) and 6 low-risk HPV (LR-HPV) genotypes. Total prevalence, annual trend, and specific age group prevalence and genotype distribution were analyzed. Results The overall HPV infection rate was 18.10% among Guangxi women self-referred to clinic for gynecologic problems in southern China. During 2016–2018, the prevalence of HPV infection showed an upward trend, from 18.21% in 2016 to 21.99% in 2018, and later it showed a downward trend, from 18.35% in 2019 to 12.26% in May 2021. Pure HR-HPV genotypes (14.36%) were found in more infections than pure LR-HPV genotypes (2.77%) and mixed genotypes (0.97%). Two peaks of HPV infection were found in the ≤ 25 years (22.94%) and 56–65 years (21.25%) groups. The six most prevalent HR-HPV genotypes were HPV 52 (4.06%), 16 (2.70%), 58 (2.24%), 51 (1.87%), 39 (1.52%), and 53 (1.52%). The three most prevalent LR-HPV genotypes were HPV 6 (1.31%), CP8304 (1.01%), and 11 (0.82%). Infection with a single HR-HPV genotype was the most common type of infection, with an overall infection rate of 12.30%. Infection with two HPV genotypes was the most common multiple HR-HPV infection type, with an infection rate of 2.35%. Conclusions The cervical HPV infection rate of women in Guangxi is very high, and there is significant age specificity. There is a need to increase HPV vaccination of young people and the screening of middle-aged and elderly people.

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Section: Discussionmentioning

confidence: 99%

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Liu-ting

Qin

et al. 2022

Infect Agents Cancer

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“…Characterization of HPV infection and the genotype distribution in men are serious clinical issues owing to the prevention of genital cancer in men and, consequently, HPV infection in women. Nonetheless, most studies on HPV infection in China have been conducted in women ( 10 , 11 ), and data on the epidemiology of HPV infection in men are quite rare. Moreover, the HPV infection rate varies between nations and regions ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…High-risk HPV genotypes mainly include HPV 16,18,31,33,35,39,45,51,52,56,58,59,66,68,83, and other genotypes mainly related to the occurrence of squamous epithelial tumors, such as cervical cancer and penile cancer (3). Low-risk genotypes mainly include HPV 6,11,40,42,43,44,61,70,72,81, and other genotypes that promote various benign lesions such as genital condyloma acuminatum (4).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence and Genotype Distribution of Human Papillomaviruses Among Men in Henan Province of China

et al. 2021

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Background: This paper aimed to assess the prevalence of human papillomavirus (HPV) infection and the associations of sociodemographic and behavioral characteristics with HPV in unvaccinated men in Henan Province before the mass administration of the HPV vaccine through a baseline survey.Methods: Between June 2015 to June 2020, 3,690 men were tested for the HPV genotype at the Henan Provincial People's Hospital. The HPV genotype was detected by a polymerase chain reaction (PCR)-based hybridization gene chip assay.Results: The overall HPV infection rate was 29.97%; The most prevalent genotypes were HPV 6 (21.76%), 11 (12.68%), 16 (8.94%), 58 (5.37%), 18 (3.41%), 84 (3.25%), 61 (3.09%), and 81 (3.09%). Low-risk HPV (LR-HPV) infection (24.91%) and single infection (17.78%) were the most prevalent forms. Age-specific HPV distribution was presented as a bimodal curve; the youngest age group (≤ 25 years) had the highest HPV infection rate (36.03%), followed by the 36–40-year-old group (33.68%). Men with Junior high school or above were more likely to have Pure-LR HPV infection. Unmarried status and smoking increased single and LR-HPV infection. Multiple lifetime sex partners and not using a condom were more likely to cause LR-HPV infection.Conclusions: The data on the prevalence and HPV infection type distribution in men in Henan Province could serve as a valuable reference to guide nationwide screening. We provide a time-based estimate of the maximum impact of the HPV vaccine and critical reference measurements important for assessing the clinical benefits of HPV vaccination and the increase in non-vaccine HPV types.

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“…A summarized global meta-analysis indicated that HPV16 was the most frequently detected type; HPV18 ranked second place in CIN3 and invasive cervical cancer (ICC); HPV45 was more common than other non-HPV16/18 types in ICC ( Guan et al., 2012 ). However, in China, HPV31/33/52/58 has a higher risk of HSIL+ than HPV18/45 in HPV-positive and cytology-negative women ( Zhang et al., 2020a ). Women with non-HPV16 18/45-positive and cytology-negative are followed up, which may be the reason for the low sensitivity of AHPV genotyping with reflex LBC triage.…”

Section: Discussionmentioning

confidence: 99%

Performance of human papillomavirus E6/E7 mRNA assay for primary cervical cancer screening and triage: Population-based screening in China

Zhang

Yang

Cui

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveCervical cancer screening is very important in the prevention and treatment of cervical cancer. In China, the cervical screening strategy needs to be improved. To explore a suitable cervical screening strategy in China, we evaluated the performance of the human papillomavirus (HPV) E6/E7 mRNA (Aptima HPV (AHPV)) assay in primary screening and different triage strategies for women undergoing routine cervical screening.MethodsA total of 10,002 women aged 35 to 65 years of age were recruited in Liaoning Province and Qingdao City, China. Specimens were tested by liquid-based cytology (LBC) and the AHPV assay, and women who tested positive on any test were referred for colposcopy. Genotyping was performed on all high-risk HPV (HR-HPV)-positive samples. Test characteristics were calculated based on histological review.ResultsWe identified 109 women with high-grade squamous intraepithelial lesion or worse (HSIL+), including six with cervical cancer. The sensitivity of AHPV was clearly higher than that of LBC (92.7 [95% CI: 87.2, 97.2] vs. 67.9 [95% CI: 59.6, 76.1], p < 0.001). The specificity of AHPV was 93.0 (95% CI: 92.5, 93.5), which was lower than that of LBC (95.2 [95% CI: 94.8, 95.6], p < 0.001). There was no statistical difference between the positive predictive value of AHPV and LBC (13.5 [95% CI: 11.2, 16.2] vs. 14.3 [95% CI: 11.4, 17.6], p = 0.695). The difference of area under the curve (AUC) values between the AHPV test (0.928 [95% CI: 0.904, 0.953]) and LBC test (0.815 [95% CI: 0.771, 0.860]) in detecting HSIL+ was statistically significant (p < 0.001). Finally, among the three triage strategies, both the sensitivity (73.4 [95% CI: 65.1, 81.7]) and AUC (0.851 [95% CI: 0.809, 0.892]) of AHPV genotyping with reflex LBC triage were the greatest.ConclusionIn summary, the AHPV assay is both specific and sensitive for detecting HSIL+ and may be suitable for use in primary cervical cancer screening in China. AHPV genotyping with reflex LBC triage may be a feasible triage strategy.

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The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China

Cited by 16 publications

References 32 publications

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

The Prevalence and Genotype Distribution of Human Papillomaviruses Among Men in Henan Province of China

Performance of human papillomavirus E6/E7 mRNA assay for primary cervical cancer screening and triage: Population-based screening in China

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