The role of hyperoxia in the pathogenesis of experimental BPD

Buczynski, Bradley W.; Maduekwe, Echezona T.; O’Reilly, Michael A.

doi:10.1053/j.semperi.2013.01.002

Cited by 129 publications

(94 citation statements)

References 125 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decreased incidence of severe ROP, need for laser treatment, and BPD with graded SpO 2 targets is consistent with the results of other studies using a lower SpO 2 target (13). Exposure to supplemental oxygen in the premature developing lung is a major factor contributing to the development of BPD (31,32). It is possible that use of initial lower SpO 2 targets and later higher SpO 2 targets protects the lung from the hyperoxia induced injury and production of cytotoxic reactive oxygen species during the early stages of lung development.…”

Section: Discussionmentioning

confidence: 99%

Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants

et al. 2016

View full text Add to dashboard Cite

Background:We compared the incidence of severe retinopathy of prematurity (ROP) and need for laser treatment before and after implementing graded pulse oximeter oxygen saturation (SpO 2 ) targets in extremely preterm infants. Mortality and other secondary outcomes were compared. Methods: Before 2002, we used 90-94% as the SpO 2 target in infants 24 0/7 -27 6/7 wk gestation and birth weight <1,000 g until 35 6/7 wk postmenstrual age (PMA). We implemented graded SpO 2 targets based on vaso-obliterative and vaso-proliferative phases of ROP in 2002. Group 1 (1995 (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) after implementation of graded SpO 2 targets based on PMA (83-89% until 32 6/7 wk, 90-94% until 35 6/7 wk and >94% at ≥ 36 wk PMA). results: There were 267 patients in Group 1 and 220 in Group 2. There was no significant difference in birth weight or gestational age. Severe ROP (adjusted OR: 0.18, 95% CI: 0.11, 0.30; P < 0.001) and laser surgery rates (adjusted OR: 0.31, 95% CI: 0.18, 0.52; P < 0.001) decreased significantly in Group 2. There was no difference in mortality (adjusted OR: 0.74, 95% CI: 0.37, 1.49; P = 0.40). conclusion: In this retrospective cohort study, implementation of graded SpO 2 targets decreased severe ROP and need for laser therapy, without increasing mortality.before, and Group 2

show abstract

Section: Discussionmentioning

confidence: 99%

Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A fokozott oxigénigény -mint a ROP esetében is -hasonló sejtkárosító hatást fejt ki a tüdőben is [40,41,42]. Fő különbség azonban, hogy a tüdőnek kell biztosítani az extrauterin élet megnöve-kedett anyacseréje számára az oxigént.…”

Section: Az Oxigén Mint Bpd-kockázati Faktorunclassified

Chronic morbidities of premature newborns

Balla

Szabó

2013

Orvosi Hetilap

View full text Add to dashboard Cite

A retinopathia prematurorum, a bronchopulmonalis dysplasia, az intraventricularis haemorrhagia és a periventricularis leukomalacia a koraszülöttek legfontosabb krónikus utóbetegségei, amelyek alapvetően befolyásolják a gyermekek életminőségét. Mivel Magyarországon a koraszülés gyakorisága az elmúlt években nem csökkent, és a kialakult kórképek nehezen kezelhetők, a megelőzés jelentősége óriási. Kockázatifaktor-elemzések bebizonyították, hogy mindegyik kórkép multifaktoriális, a számos közös kóroki tényező közül a fejlődő szervek angiogenesise az egyik legfontosabb. A koraszülés következtében számos stresszhatás miatt károsodhat az érfejlődés. A megszületés után, a méhen belüli élethez viszonyítva, a relatív hyperoxia és a csökkenő vascularis növekedési faktorok szintje érsérü-lést, akár vascularis apoptózist okozhat. Mindezek következtében, a folyamat későbbi fázisában, a hypoxia által indukált gének aktiválódnak, óriási mértékű és kóros neovascularisatio, krónikus szervkárosodás alakul ki. A normális angiogenesis megtartása és a reaktív neovascularisatio gátlása a koraszülöttek jobb életminőségét eredményezheti. Orv. Hetil., 2013, 154, 1498-1511 Kulcsszavak: retinopathia prematurorum, bronchopulmonalis dysplasia, intraventricularis haemorrhagia, periventricularis leukomalacia Chronic morbidities of premature newbornsThe most important chronic morbidities of premature newborns, deeply infl uencing quality of life, are retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular hemorrhage and periventricular leukomalacia. Since the rate of premature birth has not decreased in recent years in Hungary, and treatments of these end stage disorders are extremely diffi cult, prevention gains tremendous signifi cance. Effective prevention is based on detailed knowledge of the pathophysiological mechanisms of these special diseases having multifactorial nature sharing several common risk factors, and one is the pathological angiogenesis. This sensitive system is affected by several stress situations which are the consequences of prematurity leading to abnormal vascular growth. After birth, relative hyperoxia, compared to intrauterine life, and decreasing concentrations of vascular growth factors result in vascular injury, moreover, may cause vessel apoptosis. The consequence of this phenomenon is the activation of hypoxia responsible genes resulting in robust pathological neovascularization and organ damage during the later phase. Saving normal angiogenesis and inhibiting reactive neovascularization may lead to better quality of life in these premature infants. Orv. Hetil., 2013, 154, 1498-1511 Keywords: retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular haemorrhage, periventricular leukomalacia (Beérkezett: 2013. augusztus 6.; elfogadva: 2013. augusztus 22.) A szerkesztőség felkérésére készült közlemény. Rövidítések ANGPT-2 = angiopoetin-2; β-ARs = béta-adrenerg receptorok; BPD = bronchopulmonalis dysplasia; CP = cerebral palsy; ELBW = (extremely low birthweight) extrém kis születés...

show abstract

“…There is also evidence of altered elastin turnover, as assessed by urinary excretion of the desmosine elastin cross-link, in infants with BPD (12). These data point to disturbances to ECM production and processing in BPD, which may be mimicked in animal models, employing either hyperoxia, caloric restriction, mechanical ventilation, or preterm delivery as an injurious stimulus in rats, mice, lambs, and baboons (6,13,49,66). The lung histopathology that results is reminiscent of that of BPD in humans, with evident air space enlargement, septal wall thickening, and a reduced number of alveoli, as well as perturbations to ECM structures.…”

mentioning

confidence: 91%

Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia

Mižíková

Ruiz‐Camp

Steenbock

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

RE. Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia. Am J Physiol Lung Cell Mol Physiol 308: L1145-L1158, 2015. First published April 3, 2015 doi:10.1152/ajplung.00039.2015.-Maturation of the lung extracellular matrix (ECM) plays an important role in the formation of alveolar gas exchange units. A key step in ECM maturation is cross-linking of collagen and elastin, which imparts stability and functionality to the ECM. During aberrant late lung development in bronchopulmonary dysplasia (BPD) patients and animal models of BPD, alveolarization is blocked, and the function of ECM cross-linking enzymes is deregulated, suggesting that perturbed ECM cross-linking may impact alveolarization. In a hyperoxia (85% O 2)-based mouse model of BPD, blunted alveolarization was accompanied by alterations to lung collagen and elastin levels and cross-linking. Total collagen levels were increased (by 63%). The abundance of dihydroxylysinonorleucine collagen cross-links and the dihydroxylysinonorleucine-to-hydroxylysinonorleucine ratio were increased by 11 and 18%, respectively, suggestive of a profibrotic state. In contrast, insoluble elastin levels and the abundance of the elastin cross-links desmosine and isodesmosine in insoluble elastin were decreased by 35, 30, and 21%, respectively. The lung collagen-to-elastin ratio was threefold increased. Treatment of hyperoxia-exposed newborn mice with the lysyl oxidase inhibitor ␤-aminopropionitrile partially restored normal collagen levels, normalized the dihydroxylysinonorleucine-to-hydroxylysinonorleucine ratio, partially normalized desmosine and isodesmosine cross-links in insoluble elastin, and partially restored elastin foci structure in the developing septa. However, ␤-aminopropionitrile administration concomitant with hyperoxia exposure did not improve alveolarization, evident from unchanged alveolar surface area and alveoli number, and worsened septal thickening (increased by 12%). These data demonstrate that collagen and elastin cross-linking are perturbed during the arrested alveolarization of developing mouse lungs exposed to hyperoxia. lung development; elastin; collagen; lysyl oxidase; alveolarization POSTNATAL LUNG DEVELOPMENT in mice is characterized by a period of intensive growth and remodeling of the lung parenchyma, which rapidly (over a period of days) generates a large number of small alveoli and thus maximizes the alveolar surface area over which gas exchange can take place. Secondary septation, the generation of new septa from preexisting septa, which then divide the air spaces, peaks in mice between 4 and 7 days after birth and is largely complete 21 days after birth. In humans, secondary septation is already well underway during late stages of pregnancy, and thus occurs in utero, and continues several years into postnatal life. Disturbances to the formation of secondary septa, such as the arrested secondary septation associated with bronchopulmonary dysplasia (BPD) in humans, leads to malformed lung...

show abstract

The role of hyperoxia in the pathogenesis of experimental BPD

Cited by 129 publications

References 125 publications

Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants

Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants

Chronic morbidities of premature newborns

Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia

Contact Info

Product

Resources

About