The role of hypocalcemia and vitamin D3 in pathogenesis of phobias in chronic autoimmune Hashimoto’s thyroiditis

Abstract

Today, autoimmune Hashimoto´s thyroiditis is the most common cause of hypothyroidism. Thyroid hormones are involved in almost all metabolic processes, their deficiency leads to disruption of metabolic processes in all organs and systems, which is the reason for the rich clinical picture and variety of symptoms of hypothyroidism. The deficiency of thyroid hormones also has a significant negative impact on a person's mental health, identifying a diverse clinical picture – from mild disorders to serious mental disorders. For hypothyroidism, such psycho-neurological changes as drowsiness, weakness, loss of interest in the surroundings, loss of memory and intelligence are also characteristic. Delirious and delirious-hallucinatory conditions are described, as well as anxious and depressive conditions. Hypothyroid psychoneurological disorders have recently become more common, and therefore their diagnosis and correction are becoming more urgent. Persons with hypothyroi dism often mistakenly go not to the endocrinologist, but to a psychiatrist and receive therapy, but psychotropic drugs and antidepressants in hypothyroidism don´t give the proper effect and even are contraindicated. Hypocalcemia is very often observed with Hashimoto´s thyroiditis, it can be explained by autoimmune parathyroiditis with a hypoparathyroid clinic, that is, with autoimmune thyroiditis, the function of parathyroid glands may be disrupted. The article presents the results of our own research. A group of patients with autoimmune thyroiditis and hypothyroidism was examined. Complaints, anamnesis and clinic of the disease, levels of TSH, thyroid hormones, total and ionized calcium, inorganic phosphorus, vitamin D3 were studied.

Autoimmunology: New Branch of Medicine

“…Классические и современные данные о протективной роли такого компонента питания, как витамин D, и патогенетических последствиях его нехватки при аутоиммунных ревматологических заболеваниях были рассмотрены в докладе Ш. Азриэлант (Израиль) [39] и дополнены на примере тироидита Хасимото в докладе Л. П. Чурилова по данным российских ученых П. А. Соболевской и соавт. из лаборатории мозаики аутоиммунитета СПбГУ [40]. Эти данные нашли свое подтверждение и развитие в докладе К. Де Каролис (Италия), рассмотревшей связь дефицита витамина D и некоторых особенностей гаплотипа главного комплекса гистосовместимости (ГКГС) с антифосфолипидным синдромом, привычными выкидышами и нарушением репродуктивности у женщин.…”