The Role of<i> Rhodomyrtus tomentosa</i> (Aiton) Hassk. Fruits in Downregulation of Mast Cells-Mediated Allergic Responses

Vo, Thanh Sang; Kim, Young-Sang; Ngo, Dai‐Hung

doi:10.1155/2019/3505034

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Nr, normal; OVA-CT, control treated with only ovalbumin; Dexa., dexamethasone; SB, Scutellaria baicalensis Georgi extract. * p < 0.05, * * p < 0.01, and * * * p < 0.001 showed a significant difference from OVA-CT. degranulation via decreasing β-hexosaminidase release [23]. In our study, baicalein showed similar results inhibiting the release of β-hexosaminidase from IgE-stimulated RBL-2H3 mast cell showing significant inhibitory activity at 12.5 μg•mL −1 and 25 μg•mL −1 .…”

Section: Discussionsupporting

confidence: 80%

Enriched‐Baicalein Attenuates Allergy in Cells and Mice

Yun

Jung

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Enriched-baicalein (baicalein) from baicalin was prepared by fermentation of an SB extract with mycelium of Laetiporus sulphureus. To investigate the pharmacologic effects of baicalein, its antiallergic effect was measured in vitro and in vivo. Allergy was induced by intraperitoneal injection of ovalbumin (OVA) into Balb/c mice. As a result, baicalein showed antiallergic effects by inhibiting the release of β-hexosaminidase from immunoglobulin E- (IgE-) stimulated rat basophilic leukemia (RBL-2H3) mast cells without cytotoxicity after the methodology. After four weeks, the decrease of OVA-specific IgE level, decrease of histamine and tryptase level in serum, and then the decrease of the levels of T helper type 2 (Th2) cell-derived cytokines interleukin- (IL-) 4 and IL-13 in the splenocyte were observed. In a histological analysis for lung, baicalein excellently reduced eosinophil infiltration with the inhibition of characteristic lesions and inflammation including OVA-induced necrosis, numbers of inflammatory cells, and pulmonary edema. Therefore, these results showed that baicalein had excellent efficacy in the antiallergic activity.

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Section: Discussionsupporting

confidence: 80%

Enriched‐Baicalein Attenuates Allergy in Cells and Mice

Yun

Jung

Park³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, various pharmaceutical values of R. tomentosa including anti‐inflammatory, antioxidant, antimicrobial, anticancer, anti‐diabetic, anti‐ulcerogenic, antidepressant, and anti‐atherosclerotic activities have been evidenced in different experimental models (Vo & Ngo, ). In our previous report, R. tomentosa fruit extract (RFE) has been shown to suppress allergic responses in the activated mast cells (Vo, Kim, Ngo, & Ngo, ). This activity of RFE was suggested to be due to its biologically active components, especially phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Kim

et al. 2020

J Food Biochem

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Rhodomyrtus tomentosa was reported to contain various bioactive metabolites, especially phenolic compounds. In the present study, the suppressive activity of phenolic compound from R. tomentosa fruits on mast cell activation was investigated in vitro. The result showed that myricetin was isolated from R. tomentosa fruits and its characterization was identified by nuclear magnetic resonance spectroscopy. Notably, myricetin was found to be effective in inhibition of mast cell degranulation by attenuating the release of β‐hexosaminidase and the elevation of intracellular calcium. Moreover, myricetin exhibited inhibitory effect on the production of IL‐4 and Tumor necrosis factor alpha (TNF‐α) in a concentration‐dependent manner. Furthermore, high antioxidant activity of myricetin due to scavenging 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) and ABTS+ radicals was also evidenced. Notably, the activation of FcɛRI‐mediated signaling molecules including Syk, PLCγ, and NF‐κB was also suppressed by myricetin treatment. Accordingly, myricetin from R. tomentosa fruits could be suggested as a functional food for the amelioration of allergic diseases. Practical applications Polyphenol have been shown to exert various biological activities and health beneficial effects. Results from the present study revealed that myricetin from R. tomentosa fruits possesses the inhibitory effect on allergic response in mast cells. Therefore, myricetin from R. tomentosa fruits could be developed as a functional ingredient for the amelioration of allergic diseases.

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“…2 In addition to these nutrients, rose myrtle fruit contains a number of bioactive ingredients, including triterpenoids, flavonoids, phenols, and meroterpenoids. 3 Furthermore, studies have shown that rose myrtle fruit has many beneficial functions, such as antiallergic, 4 antiinflammatory, 5 anti-oxidant, 6,7 and anti-tumor effects. 7 Because of the known health benefits reported in ancient and modern literature, rose myrtle fruit has been used to make dietary supplements, herbal medicines, beverages, wines, jams, syrups, and cosmetics in recent decades 3,8 For example, a recent study showed that consumption of rose myrtle fruit juice suppressed hypercholesterolemia and atherosclerosis in rats fed with a high-fat high-cholesterol diet.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In addition to these nutrients, rose myrtle fruit contains a number of bioactive ingredients, including triterpenoids, flavonoids, phenols, and meroterpenoids . Furthermore, studies have shown that rose myrtle fruit has many beneficial functions, such as antiallergic, anti-inflammatory, anti-oxidant, , and anti-tumor effects …”

Section: Introductionmentioning

confidence: 99%

Optimization of Rhodomyrtus tomentosa (Rose Myrtle) Yogurt Production and Its Antioxidant Activity

Chen

Zhang

Huang

et al. 2022

ACS Food Sci. Technol.

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Rose myrtle (Rhodomyrtus tomentosa) fruit is nutrient-rich and has been shown to exert various beneficial effects on health. This study aimed to use dried rose myrtle fruit as the raw material, and the total antioxidant capacity (T-AOC) as an indicator to determine the optimal extraction process of rose myrtle and prepare a novel rose myrtle yogurt with antioxidant function. We found that the optimal extraction conditions for rose myrtle were as follows: material-to-liquid ratio of 1:15 g/mL, ethanol concentration of 60%, extraction temperature of 50 °C, and extraction time of 40 min. The T-AOC of the extract obtained was 192.43 U/mL. The optimal fermentation process of rose myrtle yogurt was carried out as follows: 50% rose myrtle extract, 16% milk powder, 6 % sucrose, and 0.5% stabilizer were homogenized and autoclaved at 95 °C for 10 min. After cooling, 0.1% fermentation agent was added; the mixture was fermented for 7 h at 43 °C and ripened for 12 h after refrigerating at 4 °C. The T-AOC of the rose myrtle yogurt was 31.48 U/mL, and it had a unique rose myrtle flavor and good sensory quality. This study not only developed a new yogurt product that meets the sensory and production requirements but also provided a scientific basis for developing novel functional food products enriched with rose myrtle.

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The Role of Rhodomyrtus tomentosa (Aiton) Hassk. Fruits in Downregulation of Mast Cells-Mediated Allergic Responses

Cited by 5 publications

References 29 publications

Enriched‐Baicalein Attenuates Allergy in Cells and Mice

Enriched‐Baicalein Attenuates Allergy in Cells and Mice

The role of myricetin fromRhodomyrtus tomentosa(Aiton) Hassk fruits on downregulation of FcɛRI‐mediated mast cell activation

Optimization of Rhodomyrtus tomentosa (Rose Myrtle) Yogurt Production and Its Antioxidant Activity

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