The Role of IFN gamma and IL-10 in Breast Cancer

Abstract

Inflammation in the tumor microenvironmentisanessentialaspectof tumor biologicalactivity. Interferon γ and IL-10 are pro-inflammatoryand anti-inflammatorycytokinesthatplay a crucialrole in regulatingthehost'simmuneresponseto cancer cells. IFN-γ and IL-10 expression are associatedwithpoor prognosis andlowsurvivalrate in breastcarcinomapatients.This cross-sectional study was performed on the 60 paraffin-embedded samples of radical mastectomy during