The role of IL-17 in vitiligo: A review

Singh, Rasnik; Lee, Kristina M.; Vujkovic-Cvijin, Ivan; Uçmak, Derya; Farahnik, Benjamin; Abrouk, Michael; Nakamura, Mio; Zhu, Tian Hao; Bhutani, Tina; Wei, Maria L.; Liao, Wilson

doi:10.1016/j.autrev.2016.01.004

Cited by 116 publications

(116 citation statements)

References 85 publications

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“…Interestingly, IL‐17 expression was also evaluated either in situ or in periphery. Contrasting with most studies, transcripts of IL‐17 were not detected in vitiligo biopsies (data not shown) and serum levels of IL‐17 were not increased in patients (Fig. b).…”

Section: Epidemiological and Clinical Features Of Vitiligo Patientscontrasting

confidence: 77%

Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

et al. 2017

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Section: Epidemiological and Clinical Features Of Vitiligo Patientscontrasting

confidence: 77%

Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

et al. 2017

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“…Several human studies have investigated the roles that Th17 cells play in vitiligo, demonstrating an increased frequency of circulating Th17 cells and elevated serum levels of IL‐17 that positively correlates with disease duration, extent, and severity of disease …”

Section: Il‐17 and Autoimmune Skin Diseasesmentioning

confidence: 99%

IL‐17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art

et al. 2019

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Recent data support the theory of the involvement of IL‐17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL‐17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL‐17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.

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“…T regulatory cells are involved in downregulation of immune response, thereby showing their importance in limiting the progression of this disease . There are many studies which have supported the role of cytokines in various inflammatory and autoimmune disorders . Previous studies have shown increased serum levels of proinflammatory cytokines like IL‐17A, IL‐1β, and also TGF‐β in vitiligo patients.…”

Section: Introductionmentioning

confidence: 99%

Expression of Th17‐ and Treg‐specific transcription factors in vitiligo patients

et al. 2020

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Background Vitiligo is mainly considered an autoimmune skin disease as the number of IL‐17 producing Th17 cells, involved in the development of autoimmune and inflammatory pathologies, increased in vitiligo skin. T regulatory cells (Tregs) seem to be altered during the disease. Thus, there must be some upstream molecular factors that regulate the cellular response to apoptotic and inflammatory stimuli. Objectives To investigate the expression of Th17‐ and Treg‐specific transcription factors in PBMCs and to evaluate the correlation between these transcription factors and cytokines in vitiligo patients. Methods We investigated 30 active NSV patients for Th17‐ and Treg‐specific transcription factors RORγt (retinoic acid‐related orphan receptor gamma t), FOXP3 (forkhead/winged helix), HELIOS, EOS, and IRF4 (Interferon Regulatory Factor 4) as well as apoptotic marker NALP1 (NACHT‐leucine‐rich‐repeat protein 1) in PBMCs with RT‐qPCR. Immunostaining was done for transcription factors and cytokines on skin sections. Results The mRNA level of FOXP3 was significantly lower in patients (0.76 fold, P < 0.001), whereas RORγt was slight but not significantly increased (0.76 fold, P = 0.06). Furthermore, NALP1 in lymphocytes was found to be increased in patients (0.69 fold, P < 0.01). The immunostaining results revealed increased expression of RORγ, IL‐17A, NALP1, and IL‐1β in vitiligo skin when compared to normal healthy skin. Conclusion Reduced FOXP3/RORγt mRNA ratio suggests thriving of the Th17 cell population in PBMCs of vitiligo patients. Increased NALP1 levels indicate the existence of an apoptotic phenomenon which correlates with the increased expression of IL‐1β in vitiligo pathogenesis.

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The role of IL-17 in vitiligo: A review

Cited by 116 publications

References 85 publications

Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

IL‐17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art

Expression of Th17‐ and Treg‐specific transcription factors in vitiligo patients

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