The Role of IL-22 in Wound Healing. Potential Implications in Clinical Practice

Zaharie, Roxana; Popa, Călin; Schlanger, Diana; Vălean, Dan; Zaharie, Florin

doi:10.3390/ijms23073693

Cited by 22 publications

(11 citation statements)

References 41 publications

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“…IL-22 is primarily involved in preservation of the mucosal barrier and protection of the host from microbial parasites in the skin ( 54 ). The anti-apoptotic effects of IL-22 ( 55 ) together with the capability to promote regeneration and proliferation highlights IL-22´s ability to promote healing and skin repair ( 56 ). Whether γδ + T cells may have a protective function by increased production of IL-22 is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

Immunoproteasome inhibition attenuates experimental psoriasis

2022

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IntroductionPsoriasis is an autoimmune skin disease associated with multiple comorbidities. The immunoproteasome is a special form of the proteasome expressed in cells of hematopoietic origin.MethodsThe therapeutic use of ONX 0914, a selective inhibitor of the immunoproteasome, was investigated in Card14ΔE138+/- mice, which spontaneously develop psoriasis-like symptoms, and in the imiquimod murine model.ResultsIn both models, treatment with ONX 0914 significantly reduced skin thickness, inflammation scores, and pathological lesions in the analyzed skin tissue. Furthermore, immunoproteasome inhibition normalized the expression of several pro-inflammatory genes in the ear and significantly reduced the inflammatory infiltrate, accompanied by a significant alteration in the αβ+ and γδ+ T cell subsets.DiscussionONX 0914 ameliorated psoriasis-like symptoms in two different murine psoriasis models, which supports the use of immunoproteasome inhibitors as a therapeutic treatment in psoriasis.

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Section: Discussionmentioning

confidence: 99%

Immunoproteasome inhibition attenuates experimental psoriasis

2022

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“…Its involvement extends to tissue remodeling processes and the promotion of angiogenesis, the creation of new blood vessels that are essential for delivering oxygen and nutrients to healing tissues. 29,55 The dysregulation of IL-22 signaling is a contributing factor to impaired wound healing and the emergence of chronic wound conditions, including diabetic foot ulcers. Understanding the multifaceted role of IL-22 in wound healing not only provides insights into the complex mechanisms of tissue repair but also highlights potential therapeutic targets for chronic wound management.…”

Section: Cytokines Involved In Wound Healingmentioning

confidence: 99%

“…It regulates the inflammatory response by modulating the synthesis of other cytokines and chemokines. IL-22 is particularly crucial in re-epithelialization, as it stimulates the migration and proliferation of epithelial cells, including keratinocytes, essential for forming a new epithelial layer over the wound …”

Section: Overview Of the Primary Inflammatory Cytokines Involved In W...mentioning

confidence: 99%

Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

Mahmoud,

Hamad,

Al Shibitini

et al. 2024

ACS Pharmacol. Transl. Sci.

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Understanding the complex interplay of pro-inflammatory and anti-inflammatory cytokines is crucial in the field of wound healing, as it holds the key to developing effective therapeutics. In the initial stages of wound healing, pro-inflammatory cytokines like IL-1β, IL-6, TNF-α, and various chemokines play vital roles in recruiting cells for debris clearance and the recruitment of growth factors. Careful regulation and timely resolution of this early inflammation are essential for optimal wound repair. As the healing process progresses, anti-inflammatory proteins such as IL-10 and IL-4 become instrumental in facilitating the transition to later stages where proinflammatory cytokines promote angiogenesis and wound remodeling. This Perspective underscores the complexity of inflammatory cytokines in wound healing research and emphasizes the need for comprehensive and unbiased methodologies in their evaluation. For robust and reliable results in wound-healing research, a more holistic approach is necessary�one that considers the roles, interactions, and timing of biological molecules, alongside careful sampling and evaluation strategies.

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“…For instance, Vg6 + cells are enriched in mucosal tissues 3 and the dermis 2,4 where they are considered resident cells. These skin resident gd T cells express a wide range of effector molecules including interleukin 17A (IL-17A) and IL-17F 5 , IL-22 6 , and the epidermal growth factor (EGF) receptor ligand 7 , and amphiregulin (AREG) 8 , which are critical for promoting tissue repair and limiting inflammation following an insult [9][10][11][12] . Although gd T cells have gathered a lot of attention for their role in cancer [13][14][15][16] , and autoimmune disorders affecting the skin such as psoriasis 17 and lupus 18 , their function during parasitic colonisation of the skin is still not well understood.…”

Section: Introductionmentioning

confidence: 99%

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronicTrypanosoma bruceiinfection

Quintana

Sinton

Chandrasegaran

et al. 2023

Preprint

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African trypanosome parasites colonise the skin in a process important for parasite transmission. However, how the skin responses to trypanosome infection remain unresolved. Here, using a combination of spatial and single cell transcriptomics, coupled within vivogenetic models, we investigated the local immune response of the skin in a murine model of infection. First, we detected a significant expansion of IL-17A-producing γδ T cells (primarily Vγ6+) in the infected murine skin compared to naïve controls that occur mainly in the subcutaneous adipose tissue. Second, interstitial preadipocytes located in the subcutaneous adipose tissue upregulate several genes involved in inflammation and antigen presentation, including T cell activation and survival.In silicocell-cell communication suggests that adipocytes trigger γδ T cell activation locallyvia Cd40, Il6, Il10,andTnfsf18signalling, amongst others. Third, mice deficient in IL-17A-producing γδ T cells show extensive inflammation, increased frequency of skin-resident IFNγ-producing CD8+T cells and limited subcutaneous adipose tissue wasting compared to wild-type infected controls, independent of TH1 CD4+T cells and parasite burden. Based on these observations, we proposed a model whereby adipocytes as well as Vγ6+cells act concertedly in the subcutaneous adipose tissue to limit skin inflammation and tissue wasting. These studies shed light onto the mechanisms of γδ T cell-mediated immunity in the skin in the context of African trypanosome infection, as well as a potential role of immature and mature adipocytes as homeostatic regulators in the skin during chronic infection.

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The Role of IL-22 in Wound Healing. Potential Implications in Clinical Practice

Cited by 22 publications

References 41 publications

Immunoproteasome inhibition attenuates experimental psoriasis

Immunoproteasome inhibition attenuates experimental psoriasis

Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronicTrypanosoma bruceiinfection

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