The Role of Immunoproteins in the Survival

Devine, Dana V.; Marjan, Jihan M.J.

doi:10.1615/critrevtherdrugcarriersyst.v14.i2.10

Cited by 62 publications

(32 citation statements)

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“…39 These are the plasma high density lipoproteins and the so-called opsonins, which bind to the surface of vesicles and mediate their endocytosis by the mononuclear phagocyte system (macrophages). The rate of liposome clearance from blood circulation will, therefore, depend on the ability of opsonins to bind to the liposome surface.…”

Section: Pharmacokinetic Considerationsmentioning

confidence: 99%

Current trends in the production and biomedical applications of liposomes: a review

Uhumwangho¹,

Okor²

2009

Journal of Medicine and Biomedical Research

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A review of literature was carried out to determine methods of production of liposomes, their stability, biodistribution and their uses as drug delivery systems. The conventional method of preparing liposomes is basically for the multilamellar vesicles (MLVs). However, other methods are used to reduce the size of these MLVs to small unilamellar vesicles (SUVs) so as to increase their plasma lifetime and consequently increase the possibility of achieving greater tissue localisation. Some of these methods of size reduction are sonication and high pressure extrusion. Each of these methods has its own advantages and disadvantages. Large unilamellar vesicles (LUVs), on the other hand, are prepared mainly by detergent removal method and reverse phase extrusion technique. There are also improved pharmacokinetic properties with liposomal drugs compared to free drugs, though some formulation factors affect the release kinetics of the liposomal drugs. The review also shows that liposomes have a lot of biomedical applications and uses. They have been used in drug targeting, oral delivery of vaccines, insulins, peptides and some compounds, which are usually degraded in the gastrointestinal tract. It has also found application in topical therapy especially in the eye and lungs. Other areas of application are in cancer chemotherapy and treatment of human immunovirus (HIV) infection. The control of the stability of liposomes is an essential prerequisite for effective use as drug carriers. Leakage of the liposome is attributable mainly to differences in lamellar structure. For instance, MLVs are less prone to leakage than ULVs. The use of a combination of saturated phospholipid and cholesterol in the formulation of the liposomes has also been found to enhance stability with lower tendency to leakage.

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Section: Pharmacokinetic Considerationsmentioning

confidence: 99%

Current trends in the production and biomedical applications of liposomes: a review

Uhumwangho¹,

Okor²

2009

Journal of Medicine and Biomedical Research

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“…One possible reason for the rapid in vivo clearance of arsonoliposomes is the opsonization of arsonoliposomes. Indeed, immediately after in vivo administration, conventional liposomes interact with serum proteins and are rapidly discovered and taken-up by the macrophages of the RES due to adsorption of opsonizing proteins on their surface (Senior, 1987;Devine and Marja, 1997). As liposome size increases, their clearance from the bloodstream is faster (Senior, 1987).…”

Section: Introductionmentioning

confidence: 99%

Incorporation of PEG-lipids in arsonoliposomes results in formation of highly stable arsenic-containing vesicles

Piperoudi

Fatouros

Ioannou

et al. 2006

Chemistry and Physics of Lipids

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“…MAC formation induces leakage and release of the liposomal contents, resulting in increased toxicity or reduced activity, caused by higher drug concentrations at non-target sites or lower drug concentrations at the target sites, respectively (41,79). The classical pathway is initiated by binding of IgM and IgG to foreign particles and subsequent binding of C1q to surface-bound IgM or IgG (41,80,84,85). IgM associated with PEGylated liposomes may work synergistically with complement components (C3b, iC3b) on the enhancement of liposome uptake by liver macrophages through receptor mediated endocytosis.…”

Section: Immunotoxicity Of Dds Complement Activationmentioning

confidence: 99%

“…The clearance of liposomes and other DDS from the blood circulation occurs after recognition by cells belonging to the mononuclear phagocyte system (MPS) (81,85,98,99). Also hepatocytes seem to play a role in the clearance of liposomes from the blood circulation (100).…”

Section: Accelerated Clearancementioning

confidence: 99%

Immunological Risk of Injectable Drug Delivery Systems

et al. 2009

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Abstract. Injectable drug delivery systems (DDS) such as particulate carriers and water-soluble polymers are being used and developed for a wide variety of therapeutic applications. However, a number of immunological risks with serious clinical implications are associated with administration of DDS. These immunological events can compromise the efficacy and safety of these systems by changing the pharmacokinetics, biodistribution and targeting capability of DDS, and by inducing hypersensitivity reactions. Antibodies induced by administration of DDS can be directed against the carrier material, the drug and/or targeting ligands associated with the DDS. Complement activation and opsonization of DDS, which may or may not be associated with antibody formation, may lead to accelerated clearance, hypersensitivity reactions and formation of membrane attack complexes resulting in premature release of the drug. Also platelets have been reported to play a role in DDS immunogenicity. Despite our curtailed understanding of the relationships between physicochemical characteristics and immunogenicity of DDS, several risk factors have been identified. Insight into these factors should be employed in the development of novel DDS with low immunological risk.

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The Role of Immunoproteins in the Survival

Cited by 62 publications

References 0 publications

Current trends in the production and biomedical applications of liposomes: a review

Current trends in the production and biomedical applications of liposomes: a review

Incorporation of PEG-lipids in arsonoliposomes results in formation of highly stable arsenic-containing vesicles

Immunological Risk of Injectable Drug Delivery Systems

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