The role of imprinted genes in mediating susceptibility to neuropsychiatric disorders

Kopsida, Eleni; Mikaelsson, Mikael Allan; Davies, William

doi:10.1016/j.yhbeh.2010.04.005

Cited by 27 publications

(23 citation statements)

References 98 publications

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“…Allele-biased expression has also been observed in a number of putative schizophrenia (SZ) and autism spectrum disorder (ASD) SZ and ASD candidate genes, including A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1 [48]. Random monoallelic expression in the brain is related to epidemiological features of neuropsychiatric disorders [49,50]. In this study, however, it is still unclear if the preferential 'A' allele expression is associated with the function of this non-coding RNA.…”

Section: Discussionmentioning

confidence: 99%

Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Kang

Sun

Xue

et al. 2015

European Journal of Cancer

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Section: Discussionmentioning

confidence: 99%

Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Kang

Sun

Xue

et al. 2015

European Journal of Cancer

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“…Over the past decade there has been increasing appreciation for the role that IGs play in regulating brain development and behavior [18][19][20][21]. Many IGs, particularly PEGs [7], are expressed in the brain and indeed the brain is the primary tissue of monoallelic expression for several IGs (e.g.…”

Section: Why Should Imprinted Genes Regulate Social Behavior?mentioning

confidence: 99%

“…The duplication or loss of particular maternal and paternal genomic regions is associated with human disorders including those with deficits in social cognition (see [21] for more information):…”

Section: Box 2 Human Social Cognition and Imprinted Genesmentioning

confidence: 99%

Is there a genomically imprinted social brain?

Curley¹

2011

BioEssays

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Imprinted genes (IGs) are expressed or silenced according to their parent-of-origin. These genes are known to play a role in regulating offspring growth, development and infant behaviors such as suckling and ultrasonic calls. In adults, neurally expressed IGs coordinate several behaviors including maternal care, sex, feeding, emotionality, and cognition. However, despite evidence from human psychiatric disorders and evolutionary theory that maternally and paternally expressed genes should also regulate social behavior, little empirical data from mouse research exists. This paper discusses data from a recent study (Garfield et al., 2011) that the IG Grb10 governs unique aspects of mouse social behavior and interprets the relevance of these findings for the future of this field.

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“…In addition, the paternally inherited IGF2 gene has been associated with superior semantic memory (for a review, see Alberini & Chen, 2012), and savant mnemonic skills are strongly linked to autism (for a review, see Hughes, 2010). Another well--studied pair of syndromes is related to imprinted genes on chromosome 15 (for reviews, see Cassidy, Schwartz, Miller, & Driscoll, 2012;Ishida & Moore, 2013;Kopsida et al, 2011;Williams, Driscoll, & Dagli, 2010). Angelman syndrome (paternal bias) is characterized by a strikingly happy demeanor but also by prolonged suckling and thus delayed weaning, hyperactivity, sleeplessness, and poor verbal skills-symptoms that suggest an increased burden on the mother.…”

Section: Effects Of Imprinted Genes On Behaviormentioning

confidence: 99%

Humans as Superorganisms: How Microbes, Viruses, Imprinted Genes, and Other Selfish Entities Shape Our Behavior

Krämer¹,

Bressan²

2017

Preprint

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Psychologists and psychiatrists tend to be little aware that (a) microbes in our brains and guts are capable of altering our behavior; (b) viral DNA that was incorporated into our DNA millions of years ago is implicated in mental disorders; (c) many of us carry the cells of another human in our brains; and (d) under the regulation of viruslike elements, the paternally inherited and maternally inherited copies of some genes compete for domination in the offspring, on whom they have opposite physical and behavioral effects. This article provides a broad overview, aimed at a wide readership, of the consequences of our coexistence with these selfish entities. The overarching message is that we are not unitary individuals but superorganisms, built out of both human and nonhuman elements; it is their interaction that determines who we are.

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The role of imprinted genes in mediating susceptibility to neuropsychiatric disorders

Cited by 27 publications

References 98 publications

Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers

Is there a genomically imprinted social brain?

Humans as Superorganisms: How Microbes, Viruses, Imprinted Genes, and Other Selfish Entities Shape Our Behavior

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