The Role of Inflammation on Vitamin D Levels in a Cohort of Pediatric Patients With Inflammatory Bowel Disease

Strisciuglio, Caterina; Cenni, Sabrina; Giugliano, Francesca Paola; Miele, Erasmo; Cirillo, Grazia; Martinelli, Massimo; Vitale, Alessandra; Tolone, Carlo; Staiano, Annamaria; Giudice, Emanuele Miraglia del; Perrone, Laura

doi:10.1097/mpg.0000000000002049

Cited by 13 publications

(20 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum concentrations of VDBP only have been studied in 1 cohort of children with IBD. This study found that serum VDBP concentrations were lower in children with IBD when compared to healthy controls, but no correlation between serum VDBP and serum 25(OH)D concentrations was found . Although loss of VDBP has been proposed as a cause of decreased 25(OH)D concentrations in dogs with hypoalbuminemia secondary to IBD, we are not aware of any previous study of serum VDBP concentrations in dogs with CIE.…”

Section: Discussioncontrasting

confidence: 65%

“…Direct loss of vitamin D has been suggested as a mechanism, but vitamin D metabolites are primarily transported in the circulation bound to vitamin D‐binding protein (VDBP [85%‐90%]), and to a lesser extent albumin (10%‐15%) . Concentrations of VDBP were decreased in a cohort of children with IBD compared to healthy controls, and in another study, serum 25(OH)D concentration was positively correlated with serum albumin concentration in a group of 130 children and young adults with IBD …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25‐hydroxycholecalciferol concentrations

Wennogle

Priestnall

Suárez‐Bonnet

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background The cause of low serum vitamin D concentrations in dogs with chronic inflammatory enteropathy (CIE) is not well understood. Objective Improve understanding of pathogenesis of low serum vitamin D concentrations in dogs with CIE by comparing several clinical, clinicopathologic, and histologic variables between CIE dogs with low and normal serum 25‐hydroxyvitamin D concentrations (25[OH]D). Animals Fifteen dogs with CIE and low serum 25[OH]D concentrations; 15 dogs with CIE and normal serum 25(OH)D concentrations. Methods Prospective cohort study. Clinical and clinicopathologic variables were compared between groups. Correlations between serum 25(OH)D concentration and histopathologic variables were assessed. Results Dogs with CIE and low serum 25(OH)D concentrations had higher canine chronic enteropathy clinical activity index scores (P = .003), lower serum α‐tocopherol (P < .001), cholesterol (P < .001), and albumin (P < .001) concentrations and higher serum C‐reactive protein (P = .004) concentrations compared to CIE dogs with normal serum 25(OH)D concentrations. Serum concentrations of vitamin D‐binding protein (VDBP) were not different between groups (P = .91). Duodenal morphologic and inflammatory histopathological scores (P = .002 and P = .004, respectively) and total histopathological scores in duodenum and combined duodenum and ileum negatively correlated with serum 25(OH)D concentration. Conclusions and Clinical Importance The pathogenesis of low serum vitamin D concentrations in dogs with CIE is likely multifactorial. Fat malabsorption deserves further study in dogs with low serum vitamin D concentration and CIE. Loss of VDBP does not appear to be an important cause of low serum vitamin D concentration in dogs with CIE.

show abstract

Section: Discussioncontrasting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25‐hydroxycholecalciferol concentrations

Wennogle

Priestnall

Suárez‐Bonnet

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…In particular, total 25OHD, vitamin D binding protein (VDBP) and bioavailable and free 25OHD are thought to be promising potential (supplementary) markers. Recently, Strisciuglio et al [28] published data from a pediatric population with IBD, albeit a relatively small sample, showing that despite low levels of total 25OHD, concentrations of free 25OHD were normal or increased. In addition, whereas a significant direct correlation was identified between free 25OHD and disease activity indices, no similar relationship was found between total 25OHD and serological markers of inflammation (CRP, fecal calprotectin).…”

Section: Introductionmentioning

confidence: 99%

Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?

Aksan

Hein

Boettger

et al. 2020

JCM

View full text Add to dashboard Cite

Evidence gained from recent studies has generated increasing interest in the role of vitamin D in extraskeletal functions such as inflammation and immunoregulation. Although vitamin D deficiency has been implicated in the pathophysiology of inflammatory diseases including inflammatory bowel disease (IBD), evidence as to whether vitamin D supplementation may cure or prevent chronic disease is inconsistent. Since 25OH-vitamin D (25OHD) has been suggested to be an acute-phase protein, its utility as a vitamin D status marker is therefore questionable. In this study, possible interactions of vitamin D and inflammation were studied in 188 patients with IBD, with high-sensitivity C-reactive protein (hsCRP) levels ≥ 5 mg/dL and/or fecal calprotectin ≥ 250 µg/g defined as biochemical evidence of inflammatory activity. Levels of 25OHD and vitamin D-binding protein (VDBP) were determined by ELISA, and 1,25-dihydroxyvitamin D (1,25OHD) and dihydroxycholecalciferol (24,25OHD) by LC-MS/MS. Free and bioavailable vitamin D levels were calculated with the validated formula of Bikle. Serum 1,25OH2D and vitamin D binding protein (VDBP) levels were shown to differ between the inflammatory and noninflammatory groups: patients with inflammatory disease activity had significantly higher serum concentrations of 1,25OH2D (35.0 (16.4–67.3) vs. 18.5 (1.2–51.0) pg/mL, p < 0.001) and VDBP (351.2 (252.2–530.6) vs. 330.8 (183.5–560.3) mg/dL, p < 0.05) than patients without active inflammation. Serum 24,25OH2D levels were negatively correlated with erythrocyte sedimentation rate (ESR) (−0.155, p = 0.049) while concentrations of serum 1,25OH2D correlated positively with hsCRP (0.157, p = 0.036). Correlations with serum VDBP levels were found for ESR (0.150, p = 0.049), transferrin (0.160, p = 0.037) and hsCRP (0.261, p < 0.001). Levels of serum free and bioavailable 25OHD showed a negative correlation with ESR (−0.165, p = 0.031, −0.205, p < 0.001, respectively) and hsCRP (−0.164, p = 0.032, −0.208, p < 0.001 respectively), and a moderate negative correlation with fecal calprotectin (−0.377, p = 0.028, −0.409, p < 0.016, respectively). Serum total 25OHD concentration was the only vitamin D parameter found to have no specific correlation with any of the inflammatory markers. According to these results, the traditional parameter, total 25OHD, still appears to be the best marker of vitamin D status in patients with inflammatory bowel disease regardless of the presence of inflammation.

show abstract

“…Some authors found that VDBP levels were inversely correlated with inflammation in pediatric IBD, and it is speculated that the underlying reasons were reduced liver production and/or intestinal losses [5].…”

Section: Vitamin D Binding Proteinmentioning

confidence: 99%

“…Vitamin D insufficiency (serum 25OHD concentration ≤20 ng/mL) and deficiency (≤15 ng/mL) are frequently found in healthy adults and adolescents, particularly in the northern hemisphere [1]. A higher prevalence of vitamin D insufficiency and deficiency among adults and children with inflammatory bowel disease (IBD) has been reported [2][3][4][5], despite the existence of controversies [6,7]. The evaluation of vitamin D status and skeletal health in pediatric IBD has been recommended, and the promotion of physical activity may be an important measure in enhancing bone mineral density [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

Nobile¹,

Tenace²,

Pappa

2019

Gastrointestinal Disorders

View full text Add to dashboard Cite

Vitamin D has a complex role in the pathogenesis of inflammatory bowel disease (IBD), which is still under investigation. We conducted a literature search using PubMed through December 2018 through the use of relevant search terms. We found an abundance of evidence to support the role of vitamin D in regulating the innate and adaptive arms of the immune system. The pathogenesis of IBD implicates the immune dysregulation of these immune system components. Proof of concept of the vitamin’s role in the pathogenesis of IBD is the mapping of the vitamin D receptor in a region of chromosome 12, where IBD is also mapped, and specific VDR polymorphisms’ link to IBD phenotypes. Further research is needed to better delineate vitamin D’s role in preventing IBD and its potential as a therapeutic target for this disease.

show abstract

The Role of Inflammation on Vitamin D Levels in a Cohort of Pediatric Patients With Inflammatory Bowel Disease

Abstract: Inflammation inversely correlates to VDBP concentrations and patients with IBD, despite their deficiency in total 25(OH)D, have normal or even higher levels of free 25(OH)D.

Cited by 13 publications

References 44 publications

Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25‐hydroxycholecalciferol concentrations

Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25‐hydroxycholecalciferol concentrations

Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?

The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

Contact Info

Product

Resources

About