The Role of Inflammatory Diet and Vitamin D on the Link between Periodontitis and Cognitive Function: A Mediation Analysis in Older Adults

Botelho, João; Leira, Yago; Viana, João; Lyra, Patrícia; Aldrey, José Manuel; Pías‐Peleteiro, Juan Manuel; Blanco, Juan; Sobrino, Tomás; Mendes, José João

doi:10.3390/nu13030924

Cited by 32 publications

(19 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The cognitive function of older participants (aged 60 or over) was estimated using four tests [ 35 , 36 ]: (1) the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test, (2) the animal fluency test, (3) the digit symbol substitution test (DSST), and (4) the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) delayed recall test. The four tests are widely used in cohort studies to estimate memory, language, speech, and cognitive functions and to screen risk factors [ 37 , 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females

et al. 2022

View full text Add to dashboard Cite

Background: The brain contains the highest level of cholesterol in the body, and the total amount of serum cholesterol in the blood has a huge impact on brain aging and cognitive performance. However, the association of total serum cholesterol with cognitive function remains uncertain. This study determines whether there is an association between the total amount of cholesterol in the blood and cognitive performance in elderly females without a history of stroke. Methods: This population-based cross-sectional study was conducted on elderly (over 60 years old) females and males without a history of stroke from 2011 to 2014 in the US National Health and Nutrition Examination Survey (NHANES). The primary exposure was total blood cholesterol, and the main outcome was cognitive performance; this association was assessed with logistic regression analysis and restricted cubic splines. Results: 1309 female and 1272 male participants were included. In females, higher total cholesterol was significantly associated with higher cognitive scores, particularly in the digit symbol substitution test (OR 0.51, 95% CI (0.36–0.72)) and the animal fluency test (OR 0.64, 95% CI (0.45–0.91)). This association remained significant in models adjusted for age, race, smoking status, education level, and chronic conditions (OR 0.40, 95% CI (0.25–0.63)). This association was not significant in males, however. Conclusions: A higher concentration of total cholesterol measured in later life may be a protective factor for cognitive performance among females over 60 years old without a history of stroke. Further, this association was more pronounced among women with higher levels of education than women with lower or no education.

show abstract

Section: Methodsmentioning

confidence: 99%

Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In some instances, associations have been also revealed with factors such as the composition of the oral microbiota (Jockel-Schneider et al, 2021 ; Li et al, 2021 ). Diet has also been related to inflammation in periodontitis (Woelber et al, 2017 ; Kotsakis et al, 2018 ; Botelho et al, 2021 ; Rowińska et al, 2021 ) and other conditions as disparate as cancer (Deng et al, 2017 ; De Almeida et al, 2019 ), diabetes (Prana et al, 2019 ; Jafaripour et al, 2020 ), cardiovascular diseases (Razquin and Martinez-Gonzalez, 2019 ; Kovell et al, 2020 ), Alzheimer's disease (McGrattan et al, 2019 ), depression (Koopman and El Aidy, 2017 ), and even COVID-19 (Iddir et al, 2020 ).…”

Section: Medical Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

View full text Add to dashboard Cite

Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

show abstract

“…On the other hand, nutrition has an impact upon oral health, particularly dietary sugars, acidic food and drinks, and eating behaviors that increase the risk for caries and dental erosion [ 5 ]. Our group recently disclosed the potential association of dietary inflammatory load with periodontitis [ 6 , 7 ], and this has never been assessed in elite athletes.…”

Section: Introductionmentioning

confidence: 99%

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Botelho

Vicente²,

Dias³

et al. 2021

Nutrients

Self Cite

View full text Add to dashboard Cite

Poor oral health in elite sport is a pressing issue, however little is known about the periodontal status of professional footballers. The aim of this study was to examine the prevalence of periodontitis in a group of professional footballers and its association with nutritional parameters and self-report non-traumatic injuries. Additionally, we assessed its association with anthropometric, dietary inflammatory load and self-reported muscular and/or articular injuries. Twenty-two professional footballers were evaluated at the beginning of the 2020–2021 season via full-mouth periodontal inspection, anthropometric measurements and the application of the dietary inflammatory index through a food intake measurement of 24 h dietary recall on two different days. Self-reporting non-traumatic muscular and articular injuries for the past 6 months were recorded from each athlete. Then we compared clinical measurements according to the periodontal status and we correlated age, periodontal and nutritional parameters. Overall, the prevalence of periodontitis was 40.9% and peri-implantitis was also observed. No significant differences were found regarding age or nutritional parameters according to the periodontal status. More non-traumatic muscular events in the past 6 months were found in the periodontitis group (55.6% vs. 38.4%), although the difference was non-significant. Both clinical attachment loss, periodontal pocket depth and the periodontal epithelial surface area revealed a significant moderate correlation with the percentage of fat mass, muscle mass, muscle mass index and total adipose folds. This group of professional footballers showed an alarming prevalence of periodontitis. Further studies shall examine whether periodontitis and periodontal treatment impact the performance of this group of athletes.

show abstract

The Role of Inflammatory Diet and Vitamin D on the Link between Periodontitis and Cognitive Function: A Mediation Analysis in Older Adults

Cited by 32 publications

References 62 publications

Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females

Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females

Periodontal Inflammation and Systemic Diseases: An Overview

Periodontal Health, Nutrition and Anthropometry in Professional Footballers: A Preliminary Study

Contact Info

Product

Resources

About