The Role of Inhalation Challenge

Rr, Rosenthal; Ca, Bruce; Lichtenstein, L M; Ps, Norman

doi:10.1159/000231381

Cited by 7 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Experimental Allergen Challenge In Relation To Symptomatic Dmentioning

confidence: 99%

“…Immediate and late asthmatic reactions can be evoked after segmental allergen challenge in rhinitic subjects without a clinical history of asthma [26]. Other studies reported small and insignificant differences between groups with asthma and those with rhinitis in response to allergen bronchoprovocation [27,28]. Muller et al [29] concluded that bronchial responsiveness to allergen bronchoprovocation in allergic individuals had little relationship to the presence or absence of clinical asthma caused by natural environmental challenge.…”

Section: Experimental Allergen Challenge In Relation To Symptomatic Dmentioning

confidence: 99%

See 1 more Smart Citation

Repeated allergen challenge as a new research model for studying allergic reactions

Bruin-Weller¹,

Weller

Monchy

1999

Clin Experimental Allergy

View full text Add to dashboard Cite

Repeated allergen challenge might be a more relevant model for studying symptomatic disease, because it gives more information on the patient's handling of chronic allergen exposure. Thus, this experimental model has more resemblance to the situation of natural allergen exposure, and the allergen load can be standardized. However, the response to repeated allergen challenge in individual patients can show a large variation, that is from a strongly enhanced response to complete diminution of the response. Successful allergen immunotherapy can change the response pattern of repeated allergen challenge in the skin into down-regulation of the late reaction. Chronic or repeated allergen exposure may result in an enhanced allergen-specific allergic response, involving allergen-specific T-cell activation. Different subsets of T cells can exert either activating or suppressive effects on inflammatory cells involved in subsequent allergic reactions. CD8+ T cells might exert suppressive effects, because they seem to be associated with a subsequent down-regulation of the late skin reaction after repeated allergen challenge (Fig. 4). Further studies are needed to compare the responses to repeated allergen challenge with the response to natural seasonal allergen exposure in the same patients and to explore possible underlying mechanisms using, for example, nasal biopsies.

show abstract

Section: Experimental Allergen Challenge In Relation To Symptomatic Dmentioning

confidence: 99%

Section: Experimental Allergen Challenge In Relation To Symptomatic Dmentioning

confidence: 99%

Repeated allergen challenge as a new research model for studying allergic reactions

Bruin-Weller¹,

Weller

Monchy

1999

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…(the dose of antigen necessary for a 35% decrease in airway conductance) (PD35 determina tions) [5]. Our equivalent to provocation doses (PD) were threshold Ascaris doses (TAD), and the signifi cance levels were +20% for resistance, and -15% for compliance.…”

Section: Introductionmentioning

confidence: 99%

Effects of FPL 55712, ETYA and Aminophylline upon Ascaris-Induced Bronchoconstriction in Cynomolgus Monkeys

Mielens¹,

Gorman²

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Dose-related impairment of pulmonary functions was induced in artificially respired, anesthetized cynomolgus monkeys by inhalation of aerosolized Ascaris antigen (AA) in ascending doses. The effects of pharmacologic agents were assessed by increases in threshold Ascaris dose (TAD). TAD were defined as the doses of AA needed for 20% increase in pulmonary resistance and 15% decrease in compliance. Inhaled FPL 55712, an SRS-A antagonist (1.24 mg through-the-valve dose; TTVD), and 5,8,11,14-eicosatetraynoic acid (ETYA), an inhibitor of lipoxygenase and cyclooxygenase (1.0 mg TTVD) resulted in significant increases in the geometric means of TAD for changes in compliance (p < 0.01). The effects of both agents upon resistance were of borderline significance. Orally administered aminophylline (30 mg/kg) had no significant effect upon mean TAD for resistance or compliance. The activities of FPL 55712 and ETYA suggest that spasmogenic leukotrienes are involved in the pulmonary allergic reactions in cynomolgus monkeys.

show abstract

Antigen-induced neutrophil chemotactic activity in man *1Correlation with bronchospasm and inhibition by disodium cromoglycate

Atkins

Norman

Zweiman

1978

Journal of Allergy and Clinical Immunology

126

View full text Add to dashboard Cite

The Role of Inhalation Challenge

Cited by 7 publications

References 4 publications

Repeated allergen challenge as a new research model for studying allergic reactions

Repeated allergen challenge as a new research model for studying allergic reactions

Effects of FPL 55712, ETYA and Aminophylline upon Ascaris-Induced Bronchoconstriction in Cynomolgus Monkeys

Antigen-induced neutrophil chemotactic activity in man *1Correlation with bronchospasm and inhibition by disodium cromoglycate

Contact Info

Product

Resources

About