The role of inhibin B in the regulation of spermatogenesis and its clinical significance in male infertility

Lihonosov, Nikolaj P.; Павлович, Лихоносов Николай; Ajub, Abdul H.; Хамидович, Аюб Абдул; Babenko, A. Yu.; Юрьевна, Бабенко Алина; Borovets, S. Yu.; Юрьевич, Боровец Сергей

doi:10.17816/uroved9139-45

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Hence, male infertility is a multifactorial syndrome that includes a wide range of disorders, affecting not only the reproductive system, but also the immunoneuroendocrine apparatus [ 10 , 14 , 15 ]. The most common causes of male infertility are genitourinary malformations, genetic disorders (particularly, cystic fibrosis and chromosome aberrations), congenital diseases of the male reproductive system (cryptorchidism, monorchism, phimosis, and hypospadias), varicocele, neuroendocrine disorders and chronic stress, traumas and inflammatory diseases of the reproductive tract both with infectious and non-infectious etiology, lifestyle factors (alcohol, tobacco smoking, drug addiction), and testicular tumors [ 5 , 11 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Immunopathological factors are leading in the pathogenesis of male infertility, essential for its cases regardless of different etiology.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Черешнев

Pichugova

Beikin³

et al. 2021

Pathophysiology

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According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, and thus preventing ovum fertilization. Infertility diagnosis requires a mandatory check for the ASAs. The concept of the blood–testis barrier is currently re-formulated, with an emphasis on informational paracrine and juxtacrine effects, rather than simple anatomical separation. The etiology of male infertility includes both autoimmune and non-autoimmune diseases but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter the blood–testis barrier, facilitating ASAs production as well. There are contradictory data on the role of ASAs in the pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism, and hypothyroidism also facilitate ASAs production. The diagnostic value of various ASAs has not yet been clearly attributed, and their cut-levels have not been determined in sera nor in ejaculate. The assessment of the autoimmunity role in the pathogenesis of male infertility is ambiguous, so the purpose of this review is to show the effects of ASAs on the pathogenesis of male infertility.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Черешнев

Pichugova

Beikin³

et al. 2021

Pathophysiology

View full text Add to dashboard Cite

show abstract

“…Hence, male infertility is a multifactorial syndrome that includes a wide range of disorders, affecting not only the reproductive system, but also the immunoneuroendocrine apparatus [10,14,15]. The most common causes of male infertility are genitourinary malformations, genetic disorders (particularly, cystic fibrosis and chromosome aberrations), congenital diseases of the male reproductive system (cryptorchidism, monorchism, phimosis, and hypospadias), varicocele, neuroendocrine disorders and chronic stress, traumas and inflam-matory diseases of the reproductive tract, both with infectious and non-infectious etiology, lifestyle factors (alcohol, tobacco smoking, drug addiction), and testicular tumors [5,11,[14][15][16][17][18][19][20][21][22][23][24][25]. Immunopathological factors are leading in pathogenesis of male infertility, essential for its cases regardless of different etiology.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Черешнев¹,

Pichugova²,

Beikin³

et al. 2021

Preprint

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According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility often is associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, thus preventing ovum fertilization. Infertility diagnosis requires mandatory check for the ASAs. The concept of blood-testis barrier currently is re-formulated with emphasis of informational paracrine and juxtacrine effects, rather than simple anatomical separation. Aetiology of male infertility includes both autoimmune and non-autoimmune diseases, but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter blood-testis barrier facilitating ASAs production as well. There are contradictory data on the role of ASAs in pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism and hypothyroidism also facilitate ASAs production. Diagnostic value of various ASAs was not yet clearly attributed, and their cut-levels not agreed neither in sera nor in ejaculate. The assessment of the autoimmunity role in pathogenesis of male infertility is ambiguous.

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“…Мужское бесплодие является полиэтиологичным заболеванием, которое может быть результатом различных расстройств [3][4][5]. Чаще всего причинами секреторной формы бесплодия являются варикоцеле, урогенитальные инфекции, гормональные, аутоиммунные и генетические нарушения.…”

Section: Introductionunclassified

Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

et al. 2020

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The aim of study was to assess the effect of low-level laser therapy (LLLT) in infrared spectrum on the main sperm parameters, sperm DNA fragmentation, MAR-test in men with nonobstructive pathozoospermia. Patients and methods. The study included 50 men from 23 to 40 years old (average age 31.0 5.4), suffering from secretory infertility. Physical examination, semen analysis, MAR-test, sperm DNA fragmentation analysis, male hormone panel, assessment of prostate microbiocenosis, testes and prostate tumor markers, ultrasound examination with color flow mapping were performed. After the examination patients had a course of LLLT in infrared spectrum on a Rubin-C device. 10 laser therapy procedures were carried out every two days with active luminescence for 3 minutes of both testicles. Control examination was done immediately after the LLLT, within one and two months. Results. Increase in sperm concentration (by an average of 25%), active mobile sperm forms (by an average of 25%), morphologically normal sperm forms (by an average of 58%) was noticed after the LLLT. MAR-test decreased by an average of 69% after the therapy. From 10 patients with initially increased sperm DNA fragmentation level, in 9 patients its level became normal after the treatment. Increase in concentration of total and free testosterone in blood plasma was noticed within one month after the LLLT. As a result of the treatment pregnancies developed in 11 (22%) out of 50 couples. Conclusions. LLLT in infrared spectrum improves sperm quality in patients with secretory infertility, decreases MAR-test level, normalizes sperm DNA-fragmentation level, increases chances of pregnancy in reproductive cycle, which allows to recommend this method as preparation for assisted reproductive technologies.

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The role of inhibin B in the regulation of spermatogenesis and its clinical significance in male infertility

Cited by 7 publications

References 20 publications

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Regarding the efficacy of low-level laser therapy in infrared spectrum in male secretory infertility

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