The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases

Weiss, E.; Mamelak, Adam J.; Morgia, Stephania La; Wang, Binghe; Feliciani, Claudio; Tulli, A; Sauder, Daniel N.

doi:10.1016/j.jaad.2003.11.075

Cited by 81 publications

(59 citation statements)

References 188 publications

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“…However, recent studies suggested the primary T-cell source for IL-10 is Th3 (also referred to as Tr1), and IL-10 suppress Th1 as well as Th2 immune responses. 20) Especially, IL-10 is reported to inhibit eosinophil survival and IL-4-induced IgE synthesis. 21) In addition to above immunesuppressive role, IL-10 is well-known to typical anti-inflammatory cytokine.…”

Section: Effects On Clinical Skin Severitymentioning

confidence: 99%

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Park

Jeong

Park

et al. 2014

Biological & Pharmaceutical Bulletin

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The roots of Rosa multiflora THUNB. (RM) has been used in oriental traditional medicines as remedies for scabies, rheumatic arthralgia and stomatitis which were practicably related with today's inflammatory and allergic diseases. In the present study, we evaluated whether RM root extract (RME) and its major constituent, 2-(3,4-dihydroxyphenyl)-6-(4-hydroxyphenyl)-8-(2,4-dihydroxyphenyl)-2,3-trans-6,7-cis-7,8-trans-3,4,7,8-tetrahydro-2H,6H-pyrano[2,3-f ] chromene-3,7,9-triol (RM-3) belongs to condensed tannins, improve atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by mite antigen. Topical application of RME as well as RM-3 improved skin severity and suppressed mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) on skin tissues, in addition, significantly reduced T helper 2 (Th2) immune responses via interleukin 10 (IL-10) up-regulation. Thus, RME, contains lots of condensed tannins such as RM-3 which possesses potent anti-inflammtory and immune-modulatory effects, may be useful for treatment of skin allergies and can be developed as new alternative herbal therapy against AD.Key words Rosa multiflora; Rosaceae; condensed tannin; proanthocyanidin; phlobatannin; atopic dermatitis Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic and eczematous skin lesion. This disease primarily occurs in infants and children, and the incidence is gradually increasing in developing as well as developed countries. Although the cause of AD has been still unclear, it has been understood as immune disorder characterized by increased immunoglobulin E (IgE) and T helper 2 (Th2) cytokine levels as well as presence of blood eosinophilia.1) Meanwhile, topical corticosteroids have been widely used as the main therapeutic strategy against AD, however they could only be used for short periods of time and in limited skin regions because of serious adverse effects such as aggravation and recurrence.2) Therefore, the demands of alternative therapies for AD have been increasing.Rosa multiflora THUNB. (RM), called as multiflora rose, baby rose, many-flowered rose and seven-sisters rose, is native to Eastern Asia. While RM has been used as rootstock for ornamental roses in Western, all parts of RM has been known as folk medicine in Eastern. Especially, hips have been widely used as diuretics and also registered on Korean and Japanese Pharmacopoeia. Meanwhile, root of RM have been rarely researched in recent year although it has been traditionally used for rheumatism, scabies and stomatitis.3) In our previous works, condensed tannins including novel stereoisomers (RM-1, 2 and 3) as well as catechin (CAT), and procyanidin B-3 (ProB3) were isolated from the roots of RM, and RM-1 and ProB3 showed to improve AD-like skin lesion in vivo. 4,5) As part of the research for development of herbal new drug, the present study was conducted to evaluate therapeutic effects of RM root extract (RME) as well as additional main compound, RM-3, belongs to phlobatannin which is a kind ...

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Section: Effects On Clinical Skin Severitymentioning

confidence: 99%

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Park

Jeong

Park

et al. 2014

Biological & Pharmaceutical Bulletin

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“…The SI values obtained by protein (DEAE) fractions were 50-70% lower than the values induced by intact living leishmania parasites and 90% lower than the total stimulation obtained by the T cell mitogen ConA. This suggests their stimulation potential in vitro appears to be selectively focus toward a particular subset of lymphocytes which may be regulatory CD8+ T cells as published (O'Daly et al 2009a;O'Daly et al, 2009b;O'Daly et al, 2010a;O'Daly et al, 2011) 7.5 The role of IL-10 in parasitic defense and autoimmune disease IL-10 plays an important role in many skin autoimmune diseases, and in certain parasitic infections, in humans as well as in experimental animals (Weiss et al, 2004). IL-10 stimulates NK cells cytotoxicity and IL-2 inducing IFNγ and TNF production.…”

Section: No Prior Sensitization Required To Recognize Amastigote Antimentioning

confidence: 99%

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

O'Daly¹

2012

Psoriasis - A Systemic Disease

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“…This cytokine is known to suppress the production of Th1 proinflammatory cytokines such as tumor necrosis factor-a (TNF-a), interferon-g (IFN-g), and IL-12, which are correlated with overt liver disease, including fibrosis and portal inflammation, and is able to enhance B-cell survival, and proliferation, and to stimulate the production of antibodies (10)(11)(12)(13). Our group previously observed that patients with chronic HCV, who had not responded to previous IFN-based therapy, had decreased disease activity after long-term IL-10 therapy (14).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Anti-HCV Antibodies in IL-10-Treated Patients

et al. 2010

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There is limited information on the direct role of the neutralizing antibody responses against hepatitis C virus (HCV) infection or methodologies to study them. Previously we have demonstrated that interleukin-10 (IL-10) administered to chronic hepatitis patients led to a decrease in disease activity, but an increase in HCV viral burden. The mechanism behind this is unknown. The objective of this study was to examine the antibody response in IL-10-treated patients. To establish a neutralization antibody assay, HCV-positive and HCV-negative sera were collected and incubated with HCV strain JFH-1 particles before culture with Huh 7.5 cells. Viral replication was measured a week later by either indirect immunofluorescence assay (iIFA) or real-time reverse transcriptase polymerase chain reaction (RT-PCR). After validation of the methodology, the sera from 30 previously-described subjects of a group previously treated with IL-10 were tested for the neutralization capacity of their antibodies. The amount of total anti-HCV antibody in the sera was also measured by direct staining of HCV full-length replicon cells. With this validated neutralization assay for anti-HCV antibodies we found that HCVneutralizing antibodies are universally present, but with significantly different titers. In patients who were treated with IL-10, the total anti-HCV antibody titers appear to be constant, but with significantly decreased antibody neutralization activity. Our study validates an assay to quantitatively determine the presence and strength of HCV-specific neutralizing antibodies. We have found that IL-10-treated patients have significantly lower HCV antibodies, but maintain the total anti-HCV antibody titer, suggesting a novel mechanism by which IL-10 treatment increases viral load in patients.

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The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases

Cited by 81 publications

References 188 publications

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

Characterization of Anti-HCV Antibodies in IL-10-Treated Patients

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