The role of interleukin‐4 in rheumatic diseases

Chen, Dong; Fu, Ting; Ji, Juan; Li, Zhenyu; Gu, Zhifeng

doi:10.1111/1440-1681.12946

Cited by 41 publications

(27 citation statements)

References 82 publications

(147 reference statements)

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“…RA is a common autoimmune disease mainly attacking the joints [40]. Consistent with the pathology of autoimmune disease, two tissues among the top 5 driver tissues fell into the immune system (Fig.…”

Section: Resultsmentioning

confidence: 81%

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

et al. 2019

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The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association studies (GWASs). This framework consists of three components which run iteratively to produce a converged prioritization list of driver tissues. Additionally, this framework also outputs a list of prioritized genes as a byproduct. We apply the framework to six representative complex diseases or traits with GWAS summary statistics, which leads to the estimation of the lung as an associated tissue of rheumatoid arthritis.Electronic supplementary materialThe online version of this article (10.1186/s13059-019-1801-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 81%

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

et al. 2019

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“…GM-CSF has been shown to be associated with persistent arthralgia in CHIKV infection [ 26 ]. The roles of the two Th2-type cytokines, IL-4, and IL-13, as anti-inflammatory cytokines have been widely demonstrated in RA [ 43 , 44 ]. The early production of these two cytokines has been shown to prevent immune-mediated arthritis in CHIKV infection [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

2020

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Chikungunya virus (CHIKV) infection has been commonly detected in tropical countries. The clinical manifestations of CHIKV infection are similar to those of rheumatoid arthritis. Outbreaks of CHIKV infection in Thailand have been reported, and the inductions of various cytokines and chemokines in CHIKV patients during those outbreaks have been shown. Although immune responses in CHIKV infection have been increasingly reported, the mechanisms associated with pathology induction are still not clearly understood. This review focuses on cytokine and chemokine production in CHIKV infection, in association with the severity of joint inflammation. Several cytokines and chemokines involved in the induction or regulation of inflammatory responses were shown to associate with the severe and persistent symptoms in CHIKV infection. Further studies on the difference in immune responses observed in an autoimmune disease, rheumatoid arthritis, infectious disease, and CHIKV infection, would provide additional insights useful for proper CHIKV therapy, especially in patients with severe joint pains.

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“…IL-4, as an essential cytokine for the differentiation of Th2 cells, is mostly produced by these T cell subtypes [29]. Monocytes, macrophages, Th2 cells, and Tregs are the main producers of IL-10 which is an anti-inflammatory cytokine inhibiting the synthesis of IL-1β, IL-8, and TNF-α.…”

Section: Levels Of Cytokines In Supernatantsmentioning

confidence: 99%

The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with Refractory Rheumatoid Arthritis

Ghoryani

Shariati-Sarabi

Tavakkol‐Afshari

et al. 2020

Journal of Immunology Research

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Rheumatoid arthritis (RA) is an advanced autoimmune disease described by joint involvement. The special properties of mesenchymal stem cells (MSCs) introduced them as a potential therapeutic candidate for RA. In this study, a single dose of autologous MSCs isolated from bone marrow (autologous BM-MSCs, 1×106 per kg) was injected intravenously into 13 patients suffering from refractory RA who were followed up within 12 months after the intervention to evaluate immunological elements. Our results showed that the gene expression of forkhead box P3 (FOXP3) in peripheral blood mononuclear cells (PBMCs) considerably increased at month 12. We found a substantial increasing trend in the culture supernatant levels of IL-10 and transforming growth factor-beta 1 (TGF-β1) in PBMCs from the beginning of the intervention up to the end. Our data may reflect the sufficient immunoregulatory effect of autologous BM-MSCs on regulatory T cells in patients suffering from refractory RA.

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The role of interleukin‐4 in rheumatic diseases

Cited by 41 publications

References 82 publications

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

Cytokines and Chemokines in Chikungunya Virus Infection: Protection or Induction of Pathology

The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with Refractory Rheumatoid Arthritis

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