The role of interleukin-6 and hepcidin 25 in the pathogenesis of&#x0D;
anemic syndrome associated with malignant neoplasms with breast cancer patients before neoadjuvant chemotherapy

Blindar, V N; Dobrovolskaya, M. M.; Khagazheeva, M. N.; Зубрихина, Г Н; Nesterova, Yu.A.; Lyubimova, N. V.; Kushlinskii, N. E.; Кононенко, И. Б.; Snegovoy, A. V.

doi:10.51620/0869-2084-2021-66-3-147-153

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…У пациенток с раком молочной железы как с анемией, так и с нормальным уровнем гемоглобина уровень ИЛ-6 и гепсидина значимо выше в сравнении со здоровыми женщинами [21].…”

Section: патогенезunclassified

Anemia of chronic diseases: current state of the problem and perspectives

Mironova

Panferov

2023

Terapevticheskii arkhiv

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Anemia of chronic diseases is a condition, that accompanies several chronic conditions, that have inflammation as an underlying cause. The article covers current concepts of pathogenesis, evaluation and treatment of this type of anemia. The new perspectives in the development of investigational methods and treatment are discussed. The new methods of iron deficiency assessment in patients with systemic inflammation are discussed separately.

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Section: патогенезunclassified

Anemia of chronic diseases: current state of the problem and perspectives

Mironova

Panferov

2023

Terapevticheskii arkhiv

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“…Therefore, regulating iron metabolism can be used as an antitumor strategy ( Hsu et al, 2020 ; Lelièvre et al, 2020 ). Hepcidin has also been previously reported to play an important role in digestive system tumors, including colorectal cancer ( Sornjai et al, 2020 ; Colorectal Cancer Cells Ectopically Express Hepcidin to Sequester Iron, 2021 ; Schwartz et al, 2021 ), gastric cancer ( Jakszyn et al, 2017 ), pancreatic cancer ( Toshiyama et al, 2018 ), and hepatocellular carcinoma ( Abd Elmonem et al, 2009 ; Udali et al, 2018 ; Wang et al, 2019 ), as well as in thoracic cancers such as breast cancer ( Blanchette-Farra et al, 2018 ; El-Mahdy et al, 2020 ; Jerzak et al, 2020 ; Shibabaw et al, 2020 ; Blindar et al, 2021 ) and lung cancer ( Chen et al, 2014 ; Fan et al, 2021 ). Collectively, hepcidin appears to play an important role in cancer.…”

Section: Introductionmentioning

confidence: 98%

An Integrated Systematic Analysis and the Clinical Significance of Hepcidin in Common Malignancies of the Male Genitourinary System

et al. 2022

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Tumors of the male genitourinary system are of great concern to the health of men worldwide. Although emerging experiment-based evidence indicates an association between hepcidin and such cancers, an integrated analysis is still lacking. For this reason, in this study, we determined the underlying oncogenic functions of hepcidin in common male genitourinary system tumors, including bladder urothelial carcinoma (BLCA), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), prostate adenocarcinoma (PRAD), and testicular germ cell tumors (TGCT) according to the data from The Cancer Genome Atlas. We found that hepcidin was highly expressed in kidney and testicular cancers. Meanwhile, the expression level of hepcidin was distinctly associated with the prognosis and immune cell infiltration in male patients with certain genitourinary system cancers, especially in KIRC. Elevated hepcidin levels also present as a risk factor in male genitourinary system tumors. Moreover, enrichment analyses revealed that some of the principal associated signaling pathways involving hepcidin and its related genes are identified as tumorigenesis-related. Immunofluorescence staining confirmed the conclusion of our immune infiltration analysis in KIRC tissue. In this study, for the first time, we provided evidence for the oncogenic function of hepcidin in different types of male genitourinary system tumors.

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Anemia syndrome associated with malignant neoplasms in patients with colorectal cancer

Blindar

Dobrovolskaya

Зубрихина

2023

Rossijskij bioterapevtičeskij žurnal

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Background. Colorectal cancer is the most commonly diagnosed cancer among all malignant neoplasms. This disease is accompanied by the development of anemic syndrome (AS). This complication not only worsens the results of treatment and, as a result, reduces overall survival, but also reduces the quality of life of patients, reduces adherence to treatment.Aim. To study the expression of hepcidin 25 (HP25), prohepcidin (PROHP), ferritin (FR), interleukin 6 (IL-6) and metabolites of nitric oxide (NOx) in the peripheral blood of patients colorectal cancer, to assess their relationship with the clinical course of the disease and with AS.Materials and methods. The study was conducted in 41 patients with colorectal cancer and AS. The content of FR, PROHP, HP25, IL-6 was determined using enzyme immunoassay. The total content of NOx in blood serum was determined using the Griess reagent after the reduction of nitrate to nitrite with cadmium granules in the presence of zinc.Results. There are three types of AS. A characteristic feature of which was microcytosis (MCV – 74.3 ± 2.1 fl) and hypochromia (MHC – 22.9 ± 1.2 pg) of erythrocytes. Type 1 of AS – iron deficiency anemia (IDA), type 2 – anemia of chronic diseases (ACD) in combination with iron deficiency erythropoiesis and type 3 – ACD with functional iron deficiency (FID). True IDA was detected in 15 (36.6 %) patients, which was classically characterized by: low concentration of FR, PROGP, GP25, IL-6 and NOx. A less significant group (9 patients, 21.9 %) had a high concentration of FR and low PROHP, GP25, IL-6, NOx, which indicated iron deficiency against the background of ACD. It differed from the first group with IDA in a significant concentration of FR, which may indicate the transition of IDA to the chronic phase of AS. Third group (17 patients, 41.5 %) – with FID – turned out to be the most numerous and characterized by a high concentration of FR (386.7 ± 41.2 ng/ml), GP25 (43.2 ± 7.1 ng/ml), PROHP (283.3 ± 18.5 ng/ml), IL-6 (24.8 ± 5.5 pg/ml), NOx (39.7 ± 5.5 µmol/l), the values were significantly higher (p <0.001) than in patients with IDA and ACD with iron deficiency erythropoiesis.Conclusion. In patients with a widespread tumor process, AS with FID is most often detected. FID was accompanied by hyperproduction of FR, IL-6, GP25, PROGP and NOx. A close correlation was noted between the studied parameters with an increase in the T-stage of colorectal cancer. This may indicate the relationship of these proteins in the development of cytokine-induced anemia in cancer patients. The data obtained can be widely used to assess the state of metabolic disorders in anemia associated with malignant neoplasms for the differential diagnosis of AS variants and adequate treatment.

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The role of interleukin-6 and hepcidin 25 in the pathogenesis of anemic syndrome associated with malignant neoplasms with breast cancer patients before neoadjuvant chemotherapy

Cited by 4 publications

References 19 publications

Anemia of chronic diseases: current state of the problem and perspectives

Anemia of chronic diseases: current state of the problem and perspectives

An Integrated Systematic Analysis and the Clinical Significance of Hepcidin in Common Malignancies of the Male Genitourinary System

Anemia syndrome associated with malignant neoplasms in patients with colorectal cancer

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