The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity

Elewa, Enass A.; Zakaria, Omyma; Mohamed, Enas I. A.; Boghdadi, Ghada

doi:10.1016/j.ejr.2013.10.003

Cited by 32 publications

(20 citation statements)

References 27 publications

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“…Th-17 is newly identified T helper subset cell and it became a hallmark of pathogenesis in various autoimmune diseases. Recently, various studies have reported that IL-17A level in SLE is elevated when compared with healthy controls [ 26 – 28 ]. Localized prominent expression of IL-17A and IFN- γ occurred in renal tissue of patients with LN-III and LN-IV compared to LN-II by IHC staining.…”

Section: Discussionmentioning

confidence: 99%

“…Different studies have shown that serum IL-17A level was significantly elevated in LN patients in comparison to SLE patient without nephritis and healthy controls, but it has no associations with clinical and laboratory parameters such as white blood cells, platelet, hematuria, dsDNA, ANA, C3, and C4 [ 31 ]. In contrast, IL-17A and IFN- γ were significantly amplified in SLE; mainly IL-17A acts as a powerful predictor cytokine because it was markedly correlated with disease activity and associated with more pyuria and proteinuria, whilst the serum level of IFN- γ was associated with more pyuria and hematuria [ 28 ]. In our study, IL-17A levels were significantly elevated in LN, especially with LN-IV compared to LN-V ( p = 0.003) and healthy control ( p = 0.001).…”

Section: Discussionmentioning

confidence: 99%

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Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Sigdel

Duan

Wang

et al. 2016

Mediators of Inflammation

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by aberrant T cell immune response. Diffuse proliferative lupus nephritis (LN-IV) is the most common, severe, and active form of lupus nephritis. In this study, we investigated the production of Th1, Th2, and Th17 cytokines in prediction of active form of LN-IV. ProcartaPlex multiplex immunoassays panels were used for detection of serum Th1, Th2, and Th17 cytokines profiling. Th1 and Th17 cytokines (IL-18, IFN-γ, IL-12p70, IL-6, and IL-17A) were considerably expressed in the serum of lupus nephritis IV patients in comparison to the healthy control. However, only IL18 and IL6 were higher in class IV versus class III lupus nephritis. Importantly, the ratios of Th1/Th2 (IL-18/IL-4) and Th17/Th2 (IL-17A/IL-4) were significantly elevated in LN-IV when compared with LN-III, LN-V, and healthy controls. Consistently, the serum cytokines IL-18, IL-17A, and IFN-γ were markedly expressed in LN-IV patient glomeruli and interstitial tissue compared to other classes of LN by IHC. ROC further suggests that IL-18 was a potential marker for LN-IV. The data from our study suggests that the early detection and quantification of these cytokines may help in prediction of active form of LN-IV.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Sigdel

Duan

Wang

et al. 2016

Mediators of Inflammation

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“…13 Sitokin dapat digunakan untuk melihat keaktifan NL. Menurut telitian yang dilakukan oleh Elewa et al, 14 mengatakan bahwa sitokin dalam air kemih bernasab dengan peningkatan aktivitas penyakit NL. Uji beda tingkat uIFN-γ memperlihatkan hasil yang bermakna yang terdapat keaktifan NL, sedangkan untuk uIL-4 tidak terdapat perbedaan yang semacam.…”

Section: Metodeunclassified

“…Uji beda tingkat uIFN-γ memperlihatkan hasil yang bermakna yang terdapat keaktifan NL, sedangkan untuk uIL-4 tidak terdapat perbedaan yang semacam. Hasil meneliti tersebut sesuai dengan penelitian dari Elewa et al, 14 yang menyatakan bahwa tingkat IFN-γ di aktivitas NL yang meningkat, sedangkan IL-4 tidak bernasab positif dengan peningkatan yang terkait penyakit NL. Renal domain SLEDAI score adalah indeks tertentu untuk melihat aktivitas NL yang terdiri dari beberapa penilaian yaitu: proteinuria dan sedimen air kemih (hematuria dan leukosituria, serta sedimen air kemih).…”

Section: Metodeunclassified

Interleukin-4 Dan Interferon Gamma Di Nefritis Lupus: Hubungan Aktivitas Penyakit Serta Kekambuhan

Achamar¹,

Farida²,

Susianti³

et al. 2018

Indonesian J. Clin. Pathol. Med. Lab.

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Sampling for urinalysis to see the activity and the degree of recurrence of Lupus Nephritis (LN) is very difficult. New biomarkersthat are more simple, sensitive, specific and non-invasive in assessing the activity of the LN need to be investigated. Interleukin-4 (IL-4)and interferon gamma (IFN-γ) were implicated to LN process. Urine samples from 17 LN patients were taken every month for 6 (six)months to examine the level of uIL-4, uIFN-γ, activity and recurrence of LN. Significant differences were observed in the uIFN-γ levelsbetween the active and inactive LN groups (p=0.012), but not in uIL-4 levels (p=0.187). Correlations between each biomarker andrenal domain score were weak (r=0.201, p=0.042 for uIL-4; r=0.268, p=0.006 for uIFN-γ). Significant differences were also found inthe uIL-4 and uIFN-γ levels against LN recurrence (p=0.033; p=0.017). The best cut off values to assess recurrences and activity of LNwere 8.17 pg/mL for uIL-4 showed a sensitivity of 74%, specificity 71%, NPV 90%, PPV 42% to assess recurrences and to assess activityof LN showed sensitivity 46%, specificity 75%, NPV 48%, PPV 78%. The cut off 18.58 pg/mL for uIFN-γ to predict recurrent and assessthe activity of LN showed sensitivity 68%%, specificity 70%, NPV 88%, PPV 40% to predict the recurrent and to assess the activity of LNshowed sensitivity 57%, specificity 64%, NPV 49%, PPV 73%. Based on the research, uIL-4 and uIFN-γ are not good enough to predictrecurrence and activity of LN

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“…These pro-inflammatory cytokines have also been implicated in SLE, with altered serum levels in SLE patients. 115,116 Interestingly, IL-17 was found to augment glomerulonephritis in a poly I:C induced type I IFN-dependent lupus murine model. 117 The role of TNF-α in SLE is controversial.…”

Section: Jak/stat Inhibition As a Therapeutic Targetmentioning

confidence: 99%

Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway

2016

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Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by impaired immune tolerance, resulting in the generation of pathogenic autoantibodies and immune complexes. Although autoreactive B lymphocytes have been the first targets for biologic therapies in SLE, the importance of the innate immune system, and in particular, pathways involved in interferon (IFN) signaling, has emerged. There are now data supporting a central role for a plasmacytoid dendritic cell-derived type I IFN pathway in SLE, with a number of biologic therapeutics and small-molecule inhibitors undergoing clinical trials. Monoclonal antibodies targeting IFN-α have completed phase II clinical trials, and an antibody against the type I IFN receptor is entering a phase III trial. However, other IFNs, such as IFN gamma, and the more recently discovered type III IFNs, are also emerging as targets in SLE; and blockade of upstream components of the IFN signaling pathway may enable inhibition of more than one IFN subtype. In this review, we discuss the current understanding of IFNs in SLE, focusing on emerging therapies.

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The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity

Cited by 32 publications

References 27 publications

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Interleukin-4 Dan Interferon Gamma Di Nefritis Lupus: Hubungan Aktivitas Penyakit Serta Kekambuhan

Targeted therapeutics in SLE: emerging strategies to modulate the interferon pathway

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