The role of iron homeostasis in adipocyte metabolism

Ma, Wenqiang; Li, Jia; Xiong, Qingqing; Feng, Yangbo; Du, Huahua

doi:10.1039/d0fo03442h

Cited by 29 publications

(22 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This has been shown in visceral adipose tissue. 27 , 28 Aquaporin 7 operates as a glycerol channel in vivo. Adipocyte glycerol permeability has a key role in the regulation of fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

George

Bobby

Dubashi

2021

SMJ

View full text Add to dashboard Cite

To assess the utility of ferritin and inflammatory biomarkers in the diagnosis of stages of breast cancer. Methods:The study consisted of 4 groups of 20 women, including the healthy control. The patients of group 1 comprised of stages I and II, group 2: stage III and group 3: stage IV of the disease. High sensitive C-reactive protein )hsCRP( and hepcidin were estimated by enzyme linked immunosorbent assay and ferritin by chemiluminescence immunoassay. The study was carried out in 2018 at

show abstract

Section: Discussionmentioning

confidence: 99%

Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

George

Bobby

Dubashi

2021

SMJ

View full text Add to dashboard Cite

show abstract

“…[31][32][33] By and large, high Hb levels reflect high-level iron stores, which may generate reactive oxygen species (ROS) such as protein carbonyls, AGEs, Ox-LDL and malondialdehyde, 34 which could lead to oxidative stress, consequently resulting β-cell 35 Furthermore, high-level iron stores may cause abnormal uptake or disposal of glucose in liver cells and muscles. [36][37][38][39] Our study has some limitations. First, the pre-pregnancy HB level was obtained from a single spot and screened within 3 months before the last menstrual period, which may not precisely reflect the true pre-pregnancy Hb level.…”

Section: Discussionmentioning

confidence: 94%

Impact of Pre-Pregnancy Hemoglobin Level on the Association Between Pre-Pregnancy Body Mass Index and Gestational Diabetes Mellitus: A Retrospective Cohort Study in a Single Center in China

Wu¹,

Ke²,

Gong³

et al. 2022

DMSO

View full text Add to dashboard Cite

To assess the impact of maternal pre-pregnancy body mass index (BMI) on gestational diabetes mellitus (GDM) based on different pre-pregnancy hemoglobin levels. Methods: This retrospective cohort study included 1289 pregnant women between June 2020 and January 2022. Clinical data were collected by reviewing their medical and antepartum screening records between 24 and 28 gestational weeks, including pre-pregnancy BMI and pre-pregnancy hemoglobin (Hb) levels. The diagnosis of GDM mainly depended on oral glucose tolerance test (OGTT) during 24-28 weeks. Restricted cubic spline (RCS) was used to investigate the association between the pre-pregnancy Hb level and the risk of GDM. Univariate and multivariate logistic regression analyses were applied to evaluate the relative risk of GDM. Results: Of the 1289 included pregnant women, 187 (14.5%) women were diagnosed with GDM in this study. The pre-pregnancy Hb level was significantly associated with GDM risk, and the pre-pregnancy Hb level of 123 g/L was identified as the threshold to stratify and assess the association between the GDM risk and the pre-pregnancy BMI. For women with a pre-pregnancy Hb level ≥123 g/L, the pre-pregnancy BMI showed a significant association with GDM risk, and the estimated incidence rate of GDM was 7.7%, 14.8%, 36.3% and 44% for underweight, normal-weight, overweight and obese pregnant women, respectively. After adjusting for potential influencing factors of GDM, the respective relative risk was 1.0 (reference), 2.04 (95% CI 0.84, 4.99), 7. 06 (2.66, 18.61), and 10.77 (2.85, 40.63) (P for trend < 0.001). Conclusion:In pregnant women with a pre-pregnancy Hb level ≥123 g/L, pre-pregnancy BMI showed a more significant association with GDM risk as compared with those with a pre-pregnancy Hb level <123 g/L.

show abstract

“…PLIN2, also known as adipose differentiation-related protein, wraps lipid droplets and phospholipids, as well as participates in the storage of neutral lipids in lipid droplets 46 , 47 . Ma et al showed that the expression of PLIN2 decreased significantly in the iron overload group, iron overload caused ferroptosis in the liver of mice with a decrease in GPX4 expression and an increase in Ptgs2 expression, resulting in a high level of lipid peroxidation, 79% decrease in the protein level of Perilipin-2 (PLIN2) 48 .…”

Section: Discussionmentioning

confidence: 99%

Identification of co-expression hub genes for ferroptosis in kidney renal clear cell carcinoma based on weighted gene co-expression network analysis and The Cancer Genome Atlas clinical data

Huang

2022

Sci Rep

View full text Add to dashboard Cite

Renal clear cell carcinoma (KIRC) is one of the most common tumors worldwide and has a high mortality rate. Ferroptosis is a major mechanism of tumor occurrence and development, as well as important for prognosis and treatment of KIRC. Here, we conducted bioinformatics analysis to identify KIRC hub genes that target ferroptosis. By Weighted gene co-expression network analysis (WGCNA), 11 co-expression-related genes were screened out. According to Kaplan Meier's survival analysis of the data from the gene expression profile interactive analysis database, it was identified that the expression levels of two genes, PROM2 and PLIN2, are respectively related to prognosis. In conclusion, our findings indicate that PROM2 and PLIN2 may be effective new targets for the treatment and prognosis of KIRC.

show abstract

The role of iron homeostasis in adipocyte metabolism

Abstract: Iron plays a vital role in the metabolism of adipose tissue. On the one hand, iron is essential for differentiation, endocrine, energy supply and other physiological functions of adipocyte. Iron...

Cited by 29 publications

References 67 publications

Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer

Impact of Pre-Pregnancy Hemoglobin Level on the Association Between Pre-Pregnancy Body Mass Index and Gestational Diabetes Mellitus: A Retrospective Cohort Study in a Single Center in China

Identification of co-expression hub genes for ferroptosis in kidney renal clear cell carcinoma based on weighted gene co-expression network analysis and The Cancer Genome Atlas clinical data

Contact Info

Product

Resources

About