The role of K+ ions on the response to carbachol of calf coronary
artery and cardiac vein during cooling

Ke, Atalik; As, Sahin; Ulusoy, HB; Doğan, Necdet

doi:10.1358/mf.2001.23.5.662118

Cited by 4 publications

(1 citation statement)

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“…The calf cardiac vein is easily accessible smooth muscle preparations and there is a limited information (13-16) about the effects of temperature in these vessels and the effects of cooling were generally studied with contractile agents. Furthermore, to our The temperature utilized in this study; 28 °C, for cooling was considered to be 'moderate cooling' temperature accordingly to our previous studies (13,17).…”

Section: Discussionmentioning

confidence: 99%

Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling

Ms¹,

Ke²

2014

BLL

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Abstract:Objective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 °C) on the vasodilatation induced by rosuvastatin (10 -9 -3x10 -4 M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects. Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 °C and continuously gassed with 95% O 2 -5% CO 2 . After a resting period, preparations were contracted with serotonin (10 -6 M) at 37 °C. Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10 -6 M). During cooling, the pIC 50 value, but not the maximal response, to rosuvastatin was signifi cantly higher than at 37 °C. Cooling to 28 °C in the presence of N G -nitro-L-arginine methyl ester (L-NAME, 10 -4 M) decreased the pIC 50 values to rosuvastatin. Conclusion:The results of the present study suggested that nitric oxide played an essential role in the coolinginduced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23

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Section: Discussionmentioning

confidence: 99%