1996
DOI: 10.1523/jneurosci.16-13-04089.1996
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The Role of K+Currents in Frequency-Dependent Spike Broadening inAplysiaR20 Neurons: A Dynamic-Clamp Analysis

Abstract: The R20 neurons of Aplysia exhibit frequency-dependent spike broadening. Previously, we had used two-electrode voltage clamp to examine the mechanisms of this spike broadening (Ma and Koester, 1995). We identified three K ϩ currents that mediate action-potential repolarization: a transient A-type K ϩ current (I Adepol ), a delayed rectifier current (I K-V ), and a Ca 2ϩ -sensitive K ϩ current (I K-Ca ). A major constraint in that study was the lack of completely selective blockers for I Adepol and I K-V , resu… Show more

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Cited by 93 publications
(68 citation statements)
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“…Under physiological conditions, spike broadening has been shown to be frequency dependent in a number of different neurons (Aldrich et al 1979;Ma and Koester 1996;Quattrocki et al 1994;Shao et al 1999). As shown in Fig.…”
Section: Maternal Diabetes Increased the Spike Half-width And Ahpmentioning
confidence: 95%
See 1 more Smart Citation
“…Under physiological conditions, spike broadening has been shown to be frequency dependent in a number of different neurons (Aldrich et al 1979;Ma and Koester 1996;Quattrocki et al 1994;Shao et al 1999). As shown in Fig.…”
Section: Maternal Diabetes Increased the Spike Half-width And Ahpmentioning
confidence: 95%
“…Because transient outward currents may contribute to repolarization (Giese et al 1998;Ma and Koester 1996;Wilson et al 2002), we had initially postulated that maternal diabetes might have decreased SK transient outward currents as an explanation for why maternal diabetes induced an increase of spike half-width. Opposite to our assumption, our data showed that maternal diabetes actually increased the SK transient outward currents.…”
Section: Maternal Diabetes Increased the Contribution Of Sk Channels mentioning
confidence: 99%
“…In contrast, PCMNs exhibited a progressive cumulative broadening pattern up to the 20th spike in a 20-Hz spike train. Previously, it has been shown that fast-inactivating voltagegated K ϩ channel-mediated currents (A-type K ϩ current: I A ) contribute to repolarization of APs (4, 61) and inactivation of I A eliminated frequency-dependent AP broadening in Aplysia neurons (41). Since BK outward currents showed a rapid inactivation (transient peaks), BK channels are well suited to contribute to spike frequency-dependent broadening (55).…”
Section: Bk Channels Contribute To Ap Repolarization and Fahpmentioning
confidence: 99%
“…During the initial step of information transmission at chemical synapses, the presynaptic action potential (AP) governs calcium influx and therefore is one key determinant of synaptic strength (Augustine, 1990;Ma and Koester, 1996;Sabatini and Regehr, 1997;Borst and Sakmann, 1999;Geiger and Jonas, 2000). We have shown recently that the currents underlying the depolarization-repolarization sequence of the AP at glutamatergic hippocampal mossy fiber boutons (MFBs) are optimized with regard to immediate functional costs (Alle et al, 2009).…”
Section: Introductionmentioning
confidence: 99%