The Role of Kisspeptin in Sexual Behavior

Hellier, Vincent; Brock, Olivier; Bakker, Julie

doi:10.1055/s-0039-3400992

Cited by 14 publications

(3 citation statements)

References 55 publications

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“…Viral tracing studies reveal that AVPV KP neurons communicate with 2 populations of neurons that express nitric oxide synthase (nNOS) in the ventrolateral part of the ventromedial hypothalamus (VMHvL) ( 301 ) and the paraventricular nucleus ( 303 ). This is pertinent given that female mice deficient in nNOS display a strong decrease in lordosis and whereas an injection of KP or GnRH fails to stimulate lordosis, a nitric oxide donor (SNAP + BAY) restores lordosis ( 301 ).…”

Section: Clinical Applications Of Kisspeptinmentioning

confidence: 99%

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

et al. 2023

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Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a wealth of evidence from both basic and translational research has laid the foundation for potential therapeutic applications. Beyond KP’s function in the hypothalamus, it is also expressed in the placenta, liver, pancreas, adipose tissue, bone, and limbic regions, giving rise to several avenues of research for use in the diagnosis and treatment of pregnancy, metabolic, liver, bone, and behavioral disorders. The role played by NKB in stimulating the hypothalamic thermoregulatory center to mediate menopausal hot flashes has led to the development of medications that antagonize its action as a novel non-steroidal therapeutic agent for this indication. Furthermore, the ability of NKB antagonism to partially suppress (but not abolish) the reproductive endocrine axis has supported its potential use for the treatment of various reproductive disorders including polycystic ovary syndrome (PCOS), uterine fibroids, and endometriosis. This review will provide a comprehensive up-to-date overview of the preclinical and clinical data that have paved the way for the development of diagnostic and therapeutic applications of KP and NKB.

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Section: Clinical Applications Of Kisspeptinmentioning

confidence: 99%

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

et al. 2023

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“…Воздействие стрессовых стимулов в раннем возрасте нарушает сроки полового созревания и снижает уровень мРНК Kiss1 в медиальной преоптической области (mPOA) у пубертатных крыс [5]. Постеродорсальная медиальная область миндалины, где были обнаружены нейроны, реагирующие на кисспептин, ассоциирована с реакциями на феромоны, что позволяет предполагать, возможную роль кисспептина в регуляции полового поведения [5,6,16,17]. Как в настоящем исследовании, так и ранее мы поддерживаем идею стероидно-независимого механизма эффектов кисспептина [18].…”

Section: обсуждение результатовunclassified

Kisspeptin reduces sexual dysfunction in a rat model of posttraumatic stress disorder

Tissen,

Lebedev,

Tsikunov

et al. 2023

Psychopharmacology & biological narcology

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Background. Sexual dysfunction is not a specific symptom of post-traumatic stress disorder (PTSD), but it is a common clinical complaint. Rodents exposed to a single traumatic event exhibit behavioral disturbances in tests designed to measure emotional behavior, the study shows. In relation to sexual behavior, exposure to acute stress leads to a decrease in the frequency of ejaculation, as well as an increase in latency to first intercourse, first intromission and ejaculation. Kisspeptin is a neuropeptide that plays an important role in the functioning of the hypothalamic-pituitary-gonadal axis. It also plays a role in sexual behavior. The purpose of this study was to examine the effects of a single traumatic event caused by a predator on sexual behavior and motivation in male rats and to correct them using hormonal and non-hormonal regulators. Methods. We used 60 copulatory naive male Wistar rats aged 90-100 days weighing 220-230 g, divided into 6 groups of 10 animals each. Animals of group 1 were intact; in the remaining groups, post-traumatic stress disorder was modeled by exposure to a predator (tiger python). In the experimental groups, animals received buserelin, kisspeptin-10 and yohimbine. An unattainable reinforcement chamber was used to assess sexual motivation. Free locomotor activity of animals was studied in the open field test. The elevated plus maze test was used to assess stress effects. Blood and brain samples were collected for testosterone and corticosterone ELISA. Results. Acute predator stress, as an animal model of post-traumatic stress disorder, significantly reduces several components of sexual motivation in male rats and increases serum corticosterone levels. Both intranasal and systemic administration of kisspeptin increases sexual motivation in male rats after chronic stress. Buserelin has a significant effect on testosterone secretion, but has little effect on sexual motivation. Systemic administration of kisspeptin partially restores testosterone production in a rat model of stress disorder. Yohimbine does not affect hormonal levels and has a disruptive effect on sexual motivation in rats. None of the hormonal and non-hormonal regulators used had an effect on corticosterone levels. Conclusion. The findings indicate that exposure to predator stress has a greater impact on sexual motivation and the hypothalamic-pituitary-adrenal axis than on sex hormone production. This creates the prerequisites for the search for new mechanisms underlying the regulation of reproductive behavior and the influence of stress factors on its implementation.

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“…In other words, kisspeptin-mediated lordosis is not dependent on GnRH signaling ( 136 ). One reasonable hypothesis is that kisspeptin-mediated-lordosis is facilitated via NPFF receptors as both NPFFR1 and NPFFR2 have been found in brain areas which are important in female sexual behavior ( 136 , 138 ). However, the hypothesis has not been confirmed by any research at present.…”

Section: The Role Of Kisspeptin In Reproductionmentioning

confidence: 99%

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction

et al. 2022

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The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction. Kisspeptin activates the signaling pathway by binding to its receptor kisspeptin receptor (KISS1R) to promote GnRH secretion, thereby regulating the hypothalamic-pituitary-gonadal axis (HPG) axis. Recent studies have shown that kisspeptin neurons located in arcuate nucleus (ARC) co-express neurokinin B (NKB) and dynorphin (Dyn). Such neurons are called KNDy neurons. KNDy neurons participate in the positive and negative feedback of estrogen to GnRH secretion. In addition, kisspeptin is a key factor in the initiation of puberty, and also regulates the processes of female follicle development, oocyte maturation, and ovulation through the HPG axis. In male reproduction, kisspeptin also plays an important role, getting involved in the regulation of Leydig cells, spermatogenesis, sperm functions and reproductive behaviors. Mutations in the KISS1 gene or disorders of the kisspeptin/KISS1R system may lead to clinical symptoms such as idiopathic hypogonadotropic hypogonadism (iHH), central precocious puberty (CPP) and female infertility. Understanding the influence of kisspeptin on the reproductive axis and related mechanisms will help the future application of kisspeptin in disease diagnosis and treatment. In this review, we critically appraise the role of kisspeptin in the HPG axis, including its signaling pathways, negative and positive feedback mechanisms, and its control on female and male reproduction.

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The Role of Kisspeptin in Sexual Behavior

Cited by 14 publications

References 55 publications

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

Kisspeptin reduces sexual dysfunction in a rat model of posttraumatic stress disorder

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction

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