The role of leiomyomas in infertility

Bulletti, Carlo; Ziegler, Dominique de; Polli, V.; Flamigni, Carlo

doi:10.1016/s1074-3804(99)80008-5

Cited by 149 publications

(96 citation statements)

References 10 publications

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“…Fortunately, myomectomy can increase the pregnancy rates in patients with leiomyoma-related infertility (Bulletti et al 1999;Surrey et al 2001). However, the mechanisms by which leiomyoma cause infertility are not fully known.…”

Section: Hox Genes and Leiomyomamentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

200

158

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HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Mü llerian defects by changing HOX gene expression. HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx. Alteration of HOX gene expression causes both uterine developmental abnormalities and impaired adult endometrial development that prevent implantation and lead to female infertility.

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Section: Hox Genes and Leiomyomamentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

200

158

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“…Fifteen women had spontaneous abortions before week 12: 3 (3%) who had surgery, 10 (9%) who did not have surgery, and 2 (2%) who did not have myomas. The conclusion of this study emphasised that myomectomy improved pregnancy rates over nonsurgical management of myomas [46].…”

Section: Infertilitymentioning

confidence: 85%

Conservative treatment of fibroids

Istre

2007

Gynecol Surg

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“…The available data addressing this issue comprise two surgical trials, one prospective study [45], and a single randomized trial [46]. Taken together, these studies failed to show an increase in clinical pregnancy rates (RR 3.77, CI 0.47-30.14), ongoing pregnancy or live birth rates (RR 1.67, CI 0.75-3.72), or spontaneous abortion rates (RR 0.76, CI 0.30-1.94).…”

Section: The Datamentioning

confidence: 99%

When Should Uterine Fibroids Be Treated?

Pritts¹,

Olive²

2012

Curr Obstet Gynecol Rep

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Fibroids are a common disorder of women, but in general, are best left untreated unless they are significantly symptomatic or an imminent health hazard. When treatment is needed, surgery remains the gold standard. For fertility, fibroids that impinge upon the uterine cavity should be removed to increase future pregnancy rates. There is no evidence that myomectomy for intramural fibroids, even those as large as 6 cm, increases fertility potential, or improves pregnancy outcome. Prophylactic myomectomy of large fibroids (largest diameter>5 cm) to decrease delivery complications is not recommended because it confers worse outcomes at delivery versus women with these large fibroids in situ. Medical treatment is transient, with most fibroids returning to pretreatment size a few months after treatment is stopped. It may, however, have a place for pretreating women before surgical removal, to treat anemia, or in perimenopausal women. Invasive radiological treatments (eg, uterine artery embolization and magnetic resonance guided ultrasound surgery) are effective for treating fibroids, but must be evaluated further before they can be recommended for women interested in future fertility.

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The role of leiomyomas in infertility

Cited by 149 publications

References 10 publications

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Conservative treatment of fibroids

When Should Uterine Fibroids Be Treated?

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