The Role of Lysosomes in the Pathogenesis of Unicameral Bone Cysts

Герасимов, А. М.; Toporova, S M; Furtseva, L N; Berezhnoy, A P; Vilensky, E V; Alekseeva, R I

doi:10.1097/00003086-199105000-00010

Cited by 40 publications

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“…The fluid of the cyst has a higher oncotic pressure than serum because of the high concentration of oncotic effective substances (protein, lysosomal enzymes, products of collagen metabolism, alkaline phosphatase) (6). A measurable concentration of catabolic enzymes (glucosaminidase, glucuronidase, peptidase, cathepsin, alkaline phosphatase) (6,15), enzymes of oxygen metabolisms (catalase, superoxiddismutase) (10) as well as prostaglandines and interleukines (9) maintain the bone-destroying effect of the cyst and stimulate osteoclasts.…”

Section: Discussionmentioning

confidence: 99%

“…A measurable concentration of catabolic enzymes (glucosaminidase, glucuronidase, peptidase, cathepsin, alkaline phosphatase) (6,15), enzymes of oxygen metabolisms (catalase, superoxiddismutase) (10) as well as prostaglandines and interleukines (9) maintain the bone-destroying effect of the cyst and stimulate osteoclasts. Therefore the aim of a causal therapy of the JBC must be the interruption of this vicious circle and the maintaining of an optimal perfusion of the bone.…”

Section: Discussionmentioning

confidence: 99%

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Elastic Stable Intramedullary Nailing for the Treatment of Complicated Juvenile Bone Cysts of the Humerus

Knorr¹,

Schmittenbecher²,

Dietz³

2003

Eur J Pediatr Surg

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Juvenile bone cysts usually are asymptomatic and may manifest as pathological fractures. Since the new method of flexible intramedullary nailing (" Elastic Stable Intramedullary Nailing" - ESIN or " Embrochage Centro- Médullaire Elastique Stable" - ECMES) has demonstrated superb results in the treatment of non-pathologic fractures of the long bones in childhood, this method is rapidly gaining popularity for the treatment of spontaneous or pathological fractures. Given the self-limiting natural history of juvenile bone cysts with eventual spontaneous healing, our goal is to stabilise the pathological fracture and the biomechanically weakened humerus. We treated 15 patients with 16 pathological fractures (one re-fracture) due to juvenile bone cysts of the proximal humerus. All fractures healed completely without pseudarthrosis. Complications were a secondary fracture in otherwise correctly positioned nails. Five of the 15 implants remain in situ, in 6 cases a repeat osteosynthesis was necessary, in one case the nails had to be changed because of the re-fracture. Ten of the 15 juvenile bone cysts healed over a period of 3 years, the nails were removed and so far there have been no further fractures in this group. In the other 5 cases, the juvenile bone cysts have progressively filled with sclerotic bone, and the nails remain in situ.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elastic Stable Intramedullary Nailing for the Treatment of Complicated Juvenile Bone Cysts of the Humerus

Knorr¹,

Schmittenbecher²,

Dietz³

2003

Eur J Pediatr Surg

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“…[13][14][15][16] Most unicameral bone cysts are asymptomatic; symptoms are usually due to pathological fractures. The differential diagnosis includes aneurysmal bone cyst, bony erosion in rheumatoid diseases, intraosseous ganglion, giant cell tumour, chondromyxoid fibroma, bone cyst associated with carpal osteoarthritis, enchondroma, chondrosarcoma, posttraumatic bone cyst, pseudarthrosis, and aseptic osteonecrosis.…”

Section: Vol 20 No 2 August 2012mentioning

confidence: 99%

Unicameral Bone Cyst of the Scaphoid: A Report of Two Cases

Javdan

Zarezadeh

Gaulke

et al. 2012

J Orthop Surg (Hong Kong)

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Unicameral bone cysts are benign, fluid-filled lesions that occur mostly in long bones (proximal humerus, 50-60%; femur, 30%) of male children aged 5 to 15 years. Occurrence in the scaphoid of an adult is rare. We report 2 such patients who presented with wrist pain, with and without a history of trauma. Both underwent curettage and bone grafting (harvested from the distal radius) and achieved good functional recovery.

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“…Although its etiology has been attributed to many factors [1][2][3][4][5][6][7][8][9], none of them has progressed beyond theory. However in recent years there is consensus among the authors that a defect in venous drainage plays a role in its etiopathogenesis [3][4][5][6]8,9].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Steroid in the Treatment of Simple Bone Cysts

Kapukaya¹

2014

Orthop Muscul Syst

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Objective: Although simple bone cysts are long-known lesions, an optimal treatment has not yet been found. There are quite different results reported in studies done with a steroid injection technique which is a popular treatment method today. The results of patients with pathological fractures who did not accept any treatment method were compared with the steroid injection technique. Method:Twenty-four patients who had steroid injection technique (Group-I) and 19 patients who had had pathological fractures and who did not accept any treatment method (Group-II) between 1995 and 2011 were included the study. Plain radiographic evaluation criteria of Capanna were used in comparisons, and MRI was used with patients whose plain radiological findings were healed with residual phase. The results were rated according to both plain radiographs and MRI findings. Results:The patients in Group-I were followed up for an average of 5.7 (2-9) years. Successful results were obtained in 18 patients (75%) according plain radiographs and in 13 patients (54%) according to MRI findings. The patients in Group-II were followed up 3 (2-7) years. Successful results were obtained in 15 patients (78.9%) according to plain radiographs and in 11 patients (57%) according to MRI findings. Conclusion:No difference was observed in terms of the healing of cysts between the patients treated with a steroid injection technique and the patients that were only observed.

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The Role of Lysosomes in the Pathogenesis of Unicameral Bone Cysts

Cited by 40 publications

References 0 publications

Elastic Stable Intramedullary Nailing for the Treatment of Complicated Juvenile Bone Cysts of the Humerus

Elastic Stable Intramedullary Nailing for the Treatment of Complicated Juvenile Bone Cysts of the Humerus

Unicameral Bone Cyst of the Scaphoid: A Report of Two Cases

The Effect of Steroid in the Treatment of Simple Bone Cysts

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