The role of MALAT1 correlates with HPV in cervical cancer

Abstract

Cervical cancer, the second most common type of cancer in women worldwide, is responsible for >275,100 mortalities each year and is associated with high-risk human papilloma virus (HR-HPV). HPVs have two important oncogenes, E6 and E7, which have crucial roles in malignant transformation in cervical cancer. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA originally identified in non-small cell lung cancer. Previous studies have revealed that MALAT1 is expressed in numerous tissue types, and is significant in maintaining the normal function of the body. However, it also appeared to be notably upregulated in numerous carcinoma types compared with adjacent non-cancerous tissues. In the present study, it was identified that MALAT1 expression was upregulated in cervical cancer cell lines compared with normal cervical squamous cell samples. Further study into the effect of MALAT1 on cellular phenotype revealed that MALAT1 was able to promote cell migration and proliferation. Of note, it was revealed that the expression of MALAT1 was decreased with the knockdown of HPV16 E6/E7 in CaSki cells. Furthermore, the investigations in clinical samples also revealed that MALAT1 was expressed in HPV-positive cervical squamous cells, but not in HPV-negative normal cervical squamous cells. These results indicate that HPV correlates with MALAT1 deregulation in cervical cancer.

Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications

“…MALAT-1 may promote cell migration and decrease cell proliferation in CaSki cells. Notably, MALAT-1 may increase cell proliferation by upregulating cyclin D1, cyclin E and cluster of differentiation K6 (18). The study conducted by Wang et al indicated that MALAT-1 was overexpressed in GC cells (22).…”

“…The study conducted by Jiang et al identified the correlation between MALAT-1 and human papillomavirus (HPV) (18). In this study, 64 cases of clinical cervical squamous cell carcinoma (SCC) samples were collected.…”

“…Numerous studies have assessed the biology of MALAT-1 in cancer (15)(16)(17)(18)(19)(20)(21)(22). The role of MALAT-1 in cellular transformation suggests that MALAT-1 has the potential to function as a biomarker and a target for novel therapeutic approaches in multiple myeloma (MM).…”

“…For example, MALAT-1 was detected in the cerebellum of human alcoholics (14). However, MALAT-1 is a typical multifunctional gene that is important in a wide array of cancers, including bladder cancer (15,16), gallbladder carcinoma (GBC) (17,18), hepatocellular carcinoma (HCC) (19) and lung (20,21) and gastric cancer (GC) (22). Therefore, understanding the regulation function of MALAT-1 within the context of cancer is of considerable significance.…”

LINC01101 and LINC00277 expression levels as novel factors in HPV‐induced cervical neoplasia

“…The expression of some lncRNAs has been reported to suffer important alterations in cervical cancer and has been associated with cancer progression and aggressiveness among the most notably are as follows: H19, HOTAIR, MALAT1, GAS5, MEG3, CCAT2 12, 13, 14, 15, 16, 17.…”