The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI‐ET treatment

Guo, Tong; Qin, Yingying; Gao, Xuan; Chen, H.; Li, G.; Ma, Jinlong; Chen, Z.-J.

doi:10.1111/j.1365-2605.2012.01284.x

Cited by 39 publications

(79 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high incidence of CPs in men is associated with the presence of Y chromosome variants. Therefore, the higher incidence of CPs in infertile men than in infertile women suggests that CPs (especially Y chromosome variations) might have deleterious effects and play important roles in reducing male infertility by influencing a variety of physiological processes, including spermatogenesis and sperm quality [14,15]. However, few studies have provided any details on the mechanisms involved.…”

Section: Introductionmentioning

confidence: 95%

“…Nevertheless, in recent clinical observations, CP carriers had more frequent reproductive failure compared with non-carriers. The effect of CPs on IVF/ICSI-ET outcomes is still controversial [4,8,[14][15][16]. Therefore, an in-depth understanding of the genetic basis of pregnancy failure is essential to appropriately manage the treatment options for infertile couples.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Zhang

Wang

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Chromosomal polymorphisms (CPs) have been reported to be associated with infertility; however, their effects on the outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) are still controversial. In this retrospective study, we aimed to evaluate the effect of CPs on IVF/ICSI-ET outcomes. Methods To investigate whether CPs affected the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population, we evaluated infertile couples with male carriers of CPs (n = 348), infertile couples with female carriers (n = 99), and unaffected couples (n = 400) who had received their first treatment cycles in our hospital between January 2013 and March 2015.Results CPs in either male or female carriers seemed to have adverse effects on IVF/ICSI-ET outcomes. CPs in male carriers affected outcomes mainly by decreasing the rates of fertilization, embryo cleavage, good quality embryos, clinical pregnancies, ongoing pregnancies, and deliveries as well as increasing the biochemical pregnancy rate (P < 0.05); CPs in female carriers affected outcomes only by lowering the embryo cleavage rate (P < 0.05). The mean fertilization rate of couples with male CP carriers undergoing IVF was significantly lower than that in those undergoing ICSI (61.1 versus 66.5 %, respectively; P = 0.0004). Conclusions Our data provide evidence for the involvement of CPs in the poor outcomes of fresh IVF/ICSI-ET cycles in a Chinese population. The use of ICSI might improve outcomes by increasing the fertilization rate for men with CPs.

show abstract

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Zhang

Wang

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Outcomes measured included the delivery rate (DR), CPR, fertilization rate, implantation rate, biochemical pregnancy rate, and miscarriage rate (calculated as defined in our previous articles) [6,7]. Follow-up on pregnancy outcome was performed by phone and recorded in our electronic medical records.…”

Section: Methodsmentioning

confidence: 99%

“…The diagnosis was further corroborated by the presence of clinical symptoms such as dysmenorrhea and irregular uterine bleeding or surgical pathology reports. Patients were monitored and managed according to the standardized clinical protocols used at the hospital [6]. …”

Section: Methodsmentioning

confidence: 99%

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Yan

Ding

Tang

et al. 2013

Gynecol Obstet Invest

View full text Add to dashboard Cite

Aims: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. Methods: We performed a retrospective, database-searched cohort study based on 10,268 patients undergoing controlled ovarian hyperstimulation and IVF/ICSI between 2009 and 2011 in our unit. Adenomyosis was diagnosed by transvaginal ultrasound. A high-quality matched cohort study with strict inclusion criteria was conducted. We compared the basic characteristics and main IVF/ICSI outcomes between the two groups. Results: We identified 83 patients with adenomyosis, of whom we included 77, and strictly matched them to 77 patients without adenomyosis. Higher day 3 estrogen levels and a longer duration of gonadotropin stimulation days were found in women with adenomyosis compared to control subjects. Patients with adenomyosis had a nonsignificant trend toward a lower clinical pregnancy rate and a higher miscarriage rate (p = 0.103 and 0.09, respectively). The delivery rate was significantly lower in the adenomyosis group in comparison to the matched controls (p = 0.022). Conclusions: Within the limitations of a retrospective study (albeit with a remarkably large number of observations), our results suggest that transvaginal ultrasound-diagnosed adenomyosis could have a negative impact on the main IVF/ICSI outcomes. Improving the diagnostic validity and scoring of disease severity in patients with adenomyosis is suggested.

show abstract

“…It is well known that both autosomal and sex chromosome genes are involved in complex regulation of spermatogenesis (15).…”

Section: Discussionmentioning

confidence: 99%

Impact of Histidine rich glycoprotein gene polymorphism in infertile male on the outcome of intracytoplasmic sperm injection (ICSI)

2017

Int. J. Curr. Res. Med. Sci.

View full text Add to dashboard Cite

Introduction: Infertility is a major concern among married couples when they fail to achieve conception.The presence of genetic anomalies both at chromosomal and gen level is a major concern in the couples opting for assisted reproductive techniques (ARTs). Male infertility may be related to various genetic polymorphisms and their combinations and not solely on a single one. Perhaps in the future, a panel of polymorphisms may guide the clinicians and patients to the best treatment alternatives of infertility. Study design: This is a cohort prospective study including 100 infertile male (oligozoospermia) to determine the impact of Histidine rich glycoprotein gene polymorphism HRG (C633T) in infertile male on the outcome of intra cytoplasmic sperm injection (ICSI). Results: In this study 56, 52 % of infertile males with successed ICSI have C/T genotype, 34.78% of them have C/C genotype and 8.69% of them have T/T genotype. While 33.33% of infertile male with failed ICSI have C/T genotype, 37.03 % of them have C/C genotype and 29.62 % of them have T/T genotype. There was significant increase of C/T mutation (56.52%) in infertile males with successful ICSI compared to failed ICSI (33.33%) p˂0.05. There was significant decrease of T/T mutation (8.69%) in infertile males with successful ICSI compared to failed ICSI (29.26%) p˂0.05. There were significant differences between HRG C/Tgenotype compared to C/C and T/T genotypes regarding sperm count, sperm concentration and total motility p˂0.05.

show abstract

The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI‐ET treatment

Cited by 39 publications

References 36 publications

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Effect of Adenomyosis on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes in Infertile Women: A Retrospective Cohort Study

Impact of Histidine rich glycoprotein gene polymorphism in infertile male on the outcome of intracytoplasmic sperm injection (ICSI)

Contact Info

Product

Resources

About