The Role of Manganese and Certain Other Trace Elements in the Prevention of Perosis

Wilgus, H. S.; Norris, L. C.; Heuser, G. F.

doi:10.1093/jn/14.2.155

Cited by 63 publications

(29 citation statements)

References 9 publications

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“…Titus (1932) applied the term perosis to a condition in chickens, originally described by Payne (1930), that was characterised by enlargement of the intertarsal joint, slipping of the gastrocnemius tendon from the distal tibiotarsal condyles and bending of leg bones. An association was later found by Wilgus et al (1937) between this abnormality and low levels of dietary manganese. Choline (Jukes, 1940), biotin (Jukes and Bird, 1942) and other members of the vitamin B group have also been associated with this condition, which is essentially a chondrodystrophy.…”

Section: Histopathologymentioning

confidence: 92%

Observations on leg deformity in broilers with particular reference to the intertarsal joint

Randall

Mills

1981

Avian Pathology

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Leg deformities were investigated in two flocks of male broilers. The most frequently encountered lesions were a progressive valgus deformity of the intertarsal joint, dyschondroplasia and an abnormal thickening of growth plates. No chondrodystrophy was observed. In one flock the peak incidence of leg deformities occurred between 3 and 7 weeks of age and 75% of all valgus abnormalities were diagnosed between 22 and 35 days of age (P < 0.001); 62% of broilers with leg abnormality in this flock had growth plate lesions in one or more bones compared to 40% in broilers without deformity (P < 0.001). Although a relationship is indicated between the presence of dyschondroplasia - particularly in the distal tibio-tarsus - and valgus deformity it was considered that dyschondroplasia would increase the likelihood of distortion without necessarily being a pre-requisite for the initial deformity. The terminology of the lesions is discussed.

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Section: Histopathologymentioning

confidence: 92%

Observations on leg deformity in broilers with particular reference to the intertarsal joint

Randall

Mills

1981

Avian Pathology

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“…Serfontein and Payne did not know at the time that they were dealing with differences in the requirement of manganese, but this was demonstrated to be the case shortly after by Wilgus et al (1937). Subsequent studies showed that chicks of heavy breeds may need as much as 50 parts per million (ppm) of manganese to ensure normal development of bone, whereas White Leghorns very rarely get perosis even on diets containing as little as 30 ppm of manganese.…”

mentioning

confidence: 99%

Genetic Variation in the Utilization of Riboflavin, Thiamine, and Other Nutrients

Hutt

1961

Annals of the New York Academy of Sciences

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“…A Mn deficiency results in a leg disorder known as perosis [2]. Insko et al reported that a minimum of 30 mg Mn/kg supplemented to the basal semi-purified ration (containing 7 mg Mn/kg) was necessary for the prevention of perosis [3].…”

Section: Discussionmentioning

confidence: 99%

“…The current NRC (1994) Mn requirement for broilers is 60 mg/kg [1], but this requirement was primarily based upon studies conducted more than 60 to 70 years ago with birds of markedly different productive potentials from those which exist today. In addition, the current estimation of Mn requirement was mainly based upon reports carried out using semi-purified diets [2][3][4], and Mn estimations using semi-purified diets may not be applicable to conventional diets because of their lower levels of phytate and fiber [5][6][7][8]. Moreover, the response criteria used in NRC (1994) were growth performance and leg weakness [4,9].…”

Section: Introductionmentioning

confidence: 99%

An Estimation of the Manganese Requirement for Broilers from 1 to 21 Days of Age

Lin

Lü

et al. 2011

Biol Trace Elem Res

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A dose-response experiment was conducted to find the sensitive and consistent biomarker for the estimation of dietary manganese (Mn) requirement and establish the optimal Mn level for broilers fed a practical corn-soybean meal diet from 1 to 21 days of age post-hatching. A total of 480 1-day-old Arbor Acres male chicks were randomly allotted to one of eight treatments with five replicates of 12 birds each and fed diets supplemented with 0, 20, 40, 60, 80, 100, 120, or 140 mg Mn/kg from reagent grade Mn sulfate. Tissue Mn concentrations, manganese-containing superoxide dismutase (MnSOD) activity, and MnSOD mRNA concentration within heart tissue were analyzed at 7, 14, and 21 days of age. Tissue Mn concentrations and heart MnSOD activity showed significant quadratic responses, and heart MnSOD mRNA concentration showed an asymptotic response to dietary supplemental Mn level, respectively. The estimate of dietary Mn for chicks from 1 to 21 days of age was 122-128 for heart Mn concentration, 141-159 for pancreas Mn concentration, 127-138 for liver Mn concentration, and 135-156 mg/kg for heart MnSOD activity, respectively. Heart MnSOD mRNA concentration was a consistent index for the estimation of the Mn requirement of broilers. Based on this index, the estimate of dietary Mn requirement for broilers from 1 to 21 days of age post-hatching was about 130 mg/kg, which was a little more than two times of the current NRC (1994) requirement.

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The Role of Manganese and Certain Other Trace Elements in the Prevention of Perosis

Cited by 63 publications

References 9 publications

Observations on leg deformity in broilers with particular reference to the intertarsal joint

Observations on leg deformity in broilers with particular reference to the intertarsal joint

Genetic Variation in the Utilization of Riboflavin, Thiamine, and Other Nutrients

An Estimation of the Manganese Requirement for Broilers from 1 to 21 Days of Age

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