The Role of Manual Occupation in the Aetiology of Dupuytren’s Disease in Men in England and Wales

Khan, Athar Ali; Rider, O J; Jayadev, Chaitra; Heras-Palou, Carlos; Giele, Henk; Goldacre, Michael J

doi:10.1016/j.jhsb.2003.08.012

Cited by 43 publications

(29 citation statements)

References 7 publications

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“…The estimated incidence of Dupuytren’s in the USA appears to be comparable with the estimated incidence (34.4 per 100,000) for the British population in 2004 among men aged 40–84 years [12]. …”

Section: Discussionmentioning

confidence: 89%

Prevalence, Incidence, and Treatments of Dupuytren's Disease in the United States: Results from a Population-Based Study

DiBenedetti

Nguyen²,

Zografos

et al. 2010

Hand (New York, N,Y.)

111

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BackgroundThis large population-based study was conducted to estimate the prevalence of Dupuytren’s disease in US adults and describe associated treatment patterns.MethodsA total of 23,103 individuals from an Internet-based research panel representative of the US population completed a brief online survey designed to identify individuals with symptoms, diagnoses, and/or treatment experience indicative of Dupuytren’s disease (mean age = 50 years).ResultsThe prevalence of Dupuytren’s disease defined as a self-reported physician diagnosis and/or surgical treatment was estimated as 1% (95% CI = 0.8–1.2), but the estimated prevalence is much higher (7.3%) when including self-reported symptoms of ropelike growth or hard bumps on the hand. The annual incidence proportion was estimated at about 3 cases per 10,000 adults. A total of 326 participants who reported relevant Dupuytren’s symptoms, treatment, and/or diagnosis completed a more in-depth survey focusing on timing of medical treatments after first symptom noticed, description of functional impairment, treatment patterns, and family history. From the second survey, most patients who reported seeking treatment for hand symptoms initially saw a primary care physician, and the mean time from noticing the first hand symptom to seeing a doctor was 23.1 months. At their first doctor visit for hand symptoms, only 9% of patients received a diagnosis of Dupuytren’s disease and 48% were advised to “wait and see” or received no treatment.ConclusionsResults from the current study indicate a number of unmet medical needs, so strategies to raise physician awareness of disease symptoms and effective treatment options may be helpful.

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Section: Discussionmentioning

confidence: 89%

Prevalence, Incidence, and Treatments of Dupuytren's Disease in the United States: Results from a Population-Based Study

DiBenedetti

Nguyen²,

Zografos

et al. 2010

Hand (New York, N,Y.)

111

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“…The population was composed of male civil servants in the Ministry of Equipment assigned to Brittany and the Pays de la Loire. Men were chosen because the disease mainly affects men, and most workplace studies have focused on male workers [Chanut, 1963;Mikkelsen, 1978;de la Caffiniere et al, 1983;Thomas and Clarke, 1992;Bovenzi, 1994;Gudmundsson et al, 2000;Khan et al, 2004]. This population was selected precisely because the occupation physicians in this French department had observed many cases of Dupuytren's disease in their working populations and decided to participate in the study by including it in their daily work for a year.…”

Section: Limitations and Strength Of The Studymentioning

confidence: 99%

“…Some studies report no significant association between this disease and either handling or gripping with force. In 2004, a study using data from the National Morbidity Survey in England and Wales found that manual occupational social class was not associated with an increased incidence of Dupuytren's disease [Khan et al, 2004]. Two other studies reported prevalence was similar in groups of manual and non-manual workers [Early, 1962;Chanut, 1963].…”

Section: Association Between Occupational Factors and Dupuytren's Dismentioning

confidence: 99%

Dupuytren's disease: Personal factors and occupational exposure

Lucas¹,

Brichet²,

Roquelaure³

et al. 2007

American J Industrial Med

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Background The etiology of Dupuytren's disease is unknown, and the role of occupational exposure is still debated. Our objective was to study the association between occupational exposures, personal risk factors and Dupuytren's disease. Methods In this cross‐sectional survey, nine occupational physicians performed clinical examinations, focused on Dupuytren's disease, of 2,406 French male civil servants employed at the Equipment Ministry in 1998 and interviewed them about medical history, leisure manual exposure and occupational biomechanical exposure to vibrations and manual work. A cumulative occupational exposure score was defined, with three levels of exposure. Results Dupuytren's disease was diagnosed in 212 men (8.8%). The occupational exposure score was significantly higher in this group of cases than in the rest of the sample (377 (SD280) vs. 223 (SD250), respectively; P < 0.0001). Occupational exposure was associated with Dupuytren's disease (adjusted Odds Ratio = 2.20 [1.39–3.45] for the intermediate and 3.10 [1.99–4.84] for the high exposure groups), with adjustment for age, leisure physical activities, alcohol consumption (≥5 servings per day), history of diabetes, epilepsy, hand trauma, and familial history of Dupuytren's disease. Conclusion Manual work exposure was associated with Dupuytren's disease after adjustment for personal risk factors. Longitudinal studies are needed to confirm these results. Am. J. Ind. Med. 51:9–15, 2008. © 2007 Wiley‐Liss, Inc.

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“…To address this controversy, an exhaustive review was published in 1996 which concluded that there is good evidence of an association between vibration exposure and Dupuytren's disease, and a weak association with forceful work 4. However, recent opinion still considers that exposure to forceful work and vibrations are not risk factors for Dupuytren's disease in manual workers 5 6. Studies have been conducted on large populations but with exposure based only on job title or work status rather than on estimated amount of vibration exposure or specific working population.…”

Section: Introductionmentioning

confidence: 99%

Heavy manual work, exposure to vibration and Dupuytren's disease? Results of a surveillance program for musculoskeletal disorders: Table 1

Descatha

Bodin

et al. 2012

Occup Environ Med

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The Role of Manual Occupation in the Aetiology of Dupuytren’s Disease in Men in England and Wales

Cited by 43 publications

References 7 publications

Prevalence, Incidence, and Treatments of Dupuytren's Disease in the United States: Results from a Population-Based Study

Prevalence, Incidence, and Treatments of Dupuytren's Disease in the United States: Results from a Population-Based Study

Dupuytren's disease: Personal factors and occupational exposure

Heavy manual work, exposure to vibration and Dupuytren's disease? Results of a surveillance program for musculoskeletal disorders: Table 1

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