The development of information technology requires an apparatus that is always fast and responsive in anticipating changes. Moreover, technology is also one of the keys to boosting the competitiveness of human resources in the instrument, which is currently getting tighter. The purpose of this study is to determine the influence of talent management and the quality of human resources on employee performance through the application of information technology systems. The research approach used in this study is quantitatively based on the study of empirical rational principles. The data collection techniques used are questionnaires. The sample consisted of 93 respondents. Data analysis used is descriptive analysis, data quality test, and hypothesis testing. The results of research on the influence of talent management and the quality of human resources on employee performance through the application of information technology systems at the BP PAUD and Dikmas offices of South Sulawesi Province show that talent management, human resource quality, and the application of information technology systems have a direct effect on performance. Of course, suppose the BP PAUD and Dikmas offices consistently apply talent management that has been done so far and pay attention to the quality of each employee they have and increasingly utilize information technology systems as work aids.