The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer

Bartnykaitė, Agnė; Savukaitytė, Aistė; Bekampytė, Justina; Ugenskienė, Rasa; Laukaitienė, Danguolė; Korobeinikova, Erika; Gudaitienė, Jurgita; Juozaitytė, Elona

doi:10.3390/biomedicines10081891

Cited by 8 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Нарушение метаболизма коллагена в соединительной ткани может быть связано с полиморфизмом генов, регулирующих его синтез и формирование ВКМ [7]. Показано, что однонуклеотидные полиморфизмы (SNP) в промоторных областях генов MMP2 и MMP9 приводят к изменению уровня их экспрессии и, таким образом, могут быть связаны с предрасположенностью к различным заболеваниям.…”

Section: конфликт интересовunclassified

Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Shevchenko

Prokofiev

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

View full text Add to dashboard Cite

Violation of the extracellular matrix components synthesis regulation contributes to the formation and growth of uterine fbroids (MM). Changes of collagen metabolism in connective tissue may be associated with polymorphism of matrix metalloproteinase (MMP) genes. Aim of the study was to analyze of the association of regulatory regions of matrix metalloproteinase genes MMP2 (rs243865), MMP3 (rs3025058), MMP9 (rs3918242) with the development of uterine myoma, its histological form, several concomitant gynecological diseases. Material and methods. The clinical study of 69 patients (23–54 years old) with uterine myoma was conducted. According to the anamnesis, 57.9 % of patients had childbirth, 46.4 % of women had an artifcial termination of pregnancy, and 15.9 % of women had endometriosis. In histological examination, in 48.14 % the nodes corresponded to the phenotype of simple fbroids with a large proportion of fbrous tissue, 51.6 % with the phenotype of proliferating fbroids. The comparison group is represented by a random population sample of women from Western Siberia. 183 women without pronounced gynecological pathologies were examined. MMP2-1306 C/T polymorphism was analyzed by TaqMan, MMP3-1171 5A/6A, MMP9-1562 C/T by restriction fragment length polymorphism method. Results. The genotype frequencies of the analyzed genes did not signifcantly diﬀer between the groups. The complex genotype MMP2-1306CC:MMP3-11715A6A:MMP9-1562CT was decreased in women with uterine myoma relative to the persons of the comparison group. In endometriosis patients MMP9-1562CC genotype was reduced and heterozygosity was increased relative to patients without endometriosis. The frequency of MMP2-1306CC:MMP9-1562CT complex genotype is signifcantly higher in women who gave birth than in women who did not give birth. Complex genotypes diﬀerences between histological variants of uterine myoma were revealed. Conclusions. The results of the study show the signifcance of polymorphism eﬀect of the regulatory regions of the MMP genes in the development and nature of the course of uterine myoma.

show abstract

Section: конфликт интересовunclassified

Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Shevchenko

Prokofiev

et al. 2023

Sibirskij nauchnyj medicinskij zhurnal

View full text Add to dashboard Cite

show abstract

“…In the case of gastric cancer, the meta-analysis showed that carriers of the TT genotype were at 1.666 times higher risk of that cancer when compared to carriers of the CC genotype ( Peng et al, 2017 ). The most recent publications also report the relationship between the MMP-9-1562C/T polymorphism and the risk of pre-eclampsia or breast cancer and its aggressiveness ( Gannoun et al, 2021 ; Bartnykaitė et al, 2022 ; Huang et al, 2022 ; Yan et al, 2022 ). It shows that the MMP-9-1562C/T polymorphism has a functional effect not only on brain cells but also on other cell types.…”

Section: Introductionmentioning

confidence: 99%

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Pabian‐Jewuła

Rylski

2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Metalloproteinase-9 (MMP-9) is one of the most strongly expressed matrix metalloproteinases (MMPs) in the brain. The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barré syndrome. This article discusses a relationship between development of the nervous system diseases and the functional single nucleotide polymorphism (SNP) at position -1562C/T within the MMP-9 gene. A pathogenic influence of MMP-9-1562C/T SNP was observed both in neurological and psychiatric disorders. The presence of the allele T often increases the activity of the MMP-9 gene promoter and consequently the expression of MMP-9 when compared to the allele C. This leads to a change in the likelihood of an occurrence of diseases and modifies the course of certain brain diseases in humans, as discussed below. The presented data indicates that the MMP-9-1562C/T functional polymorphism influences the course of many neuropsychiatric disorders in humans suggesting a significant pathological role of the MMP-9 metalloproteinase in pathologies of the human central nervous system.

show abstract

“…The enhanced-serum MMP8 level in CRC patients was significantly related to advanced-stage CRC, distant metastasis, lack of MMR, and poor survival [ 12 ]. Relevant studies have concluded that the polymorphisms of MMP8 are associated with the risk of a variety of cancers, including breast cancer [ 13 ], thyroid cancer [ 14 ], and laryngeal squamous cell carcinoma [ 15 ]. Previously, the association between MMP8 rs11225395 and CRC susceptibility has been reported [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility

Yu,

Cheng,

et al. 2023

BMC Cancer

View full text Add to dashboard Cite

Background Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene polymorphism and CRC risk in the Chinese Han population. Method This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model. Results MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04–1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m2, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer. Conclusions Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.

show abstract

The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer

Cited by 8 publications

References 39 publications

Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Features of matrix metalloproteinases MMP2, MMP3, MMP9 genes regulatory region polymorphism in patients with uterine fbroids

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility

Contact Info

Product

Resources

About