The Role of Medical Acupuncture Therapy in Alzheimer's Disease

Teja, Yolanda; Helianthi, Dwi Rachma; Nareswari, Irma

doi:10.1089/acu.2021.0014

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Acupuncture and moxibustion in the treatment of AD has the advantages of early, safe, effective [ 206 ] and benign bidirectional adjustment [ 207 ]. Acupuncture stimulation of different acupoints can play a role by inhibiting the production and aggregation of Aβ, preventing excessive phosphorylation and aggregation of tau protein, regulating the cholinergic system, inhibiting neuroinflammation, reducing oxidative damage and so on.In recent years, brain imaging technologies, such as functional magnetic resonance imaging and positron emission tomography, have been used to assess brain responses to acupuncture in a dynamic, visual, and objective way.…”

Section: Discussionmentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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Alzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD. Resveratrol, curcumin, kaempferol and other Chinese herbal medicine components can significantly inhibit the neuroinflammation of AD in vivo and in vitro, and are candidates for the treatment of AD. Acupuncture can alleviate the memory and cognitive impairment of AD by improving neuroinflammation, synaptic plasticity, nerve cell apoptosis and reducing the production and aggregation of amyloid β protein (Aβ) in the brain. It has the characteristics of early, safe, effective and benign bidirectional adjustment. The purpose of this paper is to provide a basis for improving the clinical strategies of TCM for the treatment of AD. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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“…therapeutic procedure that stimulates acupoints, has been thoroughly researched and used to treat Alzheimer's disease [33]. Acupuncture therapy improved cognitive function in patients with Alzheimer's disease and elderly people with mild cognitive impairment, according to clinical studies and systematic reviews [34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Effects of Electroacupuncture on the Correlation between Serum and Central Immunity in AD Model Animals

Jiang

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The goal was to investigate the connection between neuroinflammation in the brain and serum inflammatory markers as Alzheimer’s disease progressed. We also sought to determine whether electroacupuncture had an effect on inflammatory markers found in blood and other brain regions. Methods. As an animal model for AD, we used senescence-accelerated mouse prone 8 (SAMP8) mice. To examine the effects and probable mechanism of electroacupuncture, we used HE staining, immunofluorescence staining, western blotting, and enzyme-linked immunosorbent assay. Results. Electroacupuncture therapy protected neurons, significantly downregulated the Iba-1 level in the hippocampus ( p value was 0.003), frontal lobe cortex ( p value was 0.042), and temporal lobe cortex ( p value was 0.013) of the AD animal model, all of which had significantly lower levels of IL-6 ( p value was 0.001), IL-1β ( p value was 0.001), and TNF-α ( p value was 0.001) in their serum. Conclusion. The amounts of IL-6, IL-1β, and TNF-α detected in the serum were strongly linked to the levels discovered in the hippocampus and the frontal lobes of the brain, respectively. A better understanding of the electroacupuncture process as well as the course of Alzheimer’s disease and the therapeutic benefits of electroacupuncture may be gained by using biomarkers such as serum inflammatory marker biomarkers.

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“…Current research has demonstrated that the phosphorylation of tau protein is closely related to NFT and AD, and tau protein is the only essential component of NFT (Li R. et al, 2022;Yang B. et al, 2022). Hyperphosphorylation of Tau protein not only reduces its activity of promoting microtubule assembly but also further destroys microtubules by consuming normal tau protein, microtubule-associated protein MAP1, and MAP2, resulting in axoplasmic transport disorder, neuronal process breakage, neuronal degeneration and disintegration, neuronal degeneration and formation of NFT (Teja et al, 2021). Neuronal fiber degeneration caused by NFT act an essential role in the pathogenesis of AD and is parallel to the clinical dementia symptoms of AD patients (Wang et al, 2021).…”

Section: Inhibition Of Microtubule-associated Protein Expressionmentioning

confidence: 99%

Effect and mechanism of acupuncture on Alzheimer’s disease: A review

Dong

Zhu

et al. 2023

Front. Aging Neurosci.

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With the development trend of an aging society, Alzheimer’s disease (AD) has become an urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients leads to a decline in the ability to perform daily living and abnormalities in behavior and personality, causing abnormal psychiatric symptoms, which seriously affect the daily life of patients. Currently, mainly drug therapy is used for AD patients in the clinic, but a large proportion of patients will experience drug efficacy not working, and even some drugs bring severe sleep disorders. Acupuncture, with its unique concept and treatment method, has been validated through a large number of experiments and proved its reliability of acupuncture in the treatment of AD. Many advances have been made in the study of the neurobiological mechanisms of acupuncture in the treatment of AD, further demonstrating the good efficacy and unique advantages of acupuncture in the treatment of AD. This review first summarizes the pathogenesis of AD and then illustrates the research progress of acupuncture in the treatment of AD, which includes the effect of acupuncture on the changes of biochemical indicators in AD in vivo and the specific mechanism of action to exert the therapeutic effect. Changes in relevant indicators of AD similarly further validate the effectiveness of acupuncture treatment. The clinical and mechanistic studies of acupuncture in the treatment of AD are intensified to fit the need for social development. It is believed that acupuncture will achieve new achievements in the treatment of AD as research progresses.

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The Role of Medical Acupuncture Therapy in Alzheimer's Disease

Cited by 6 publications

References 34 publications

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Effects of Electroacupuncture on the Correlation between Serum and Central Immunity in AD Model Animals

Effect and mechanism of acupuncture on Alzheimer’s disease: A review

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