The role of microbes in the pathogenesis of acute rhinosinusitis in young adults

Autio, Timo J.; Tapiainen, Terhi; Koskenkorva, Timo; Närkiö, Mervi; Lappalainen, Maija; Nikkari, Simo; Hemmilä, Heidi; Koskela, Katja A.; Koskela, Markku; Koivunen, Petri; Alho, Olli‐Pekka

doi:10.1002/lary.24862

Cited by 24 publications

(37 citation statements)

References 29 publications

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“…Thirty‐nine patients (78%) had respiratory virus nucleic acid in their nasopharynx at enrolment . Twenty patients (40%) underwent a maxillary sinus aspiration.…”

Section: Resultsmentioning

confidence: 99%

“…Background information was collected at enrolment, and a viral polymerase chain reaction was taken from the nasopharynx as described previously . The presence of nasal symptoms was recorded in symptom diaries .…”

Section: Methodsmentioning

confidence: 99%

“…If the third CBCT scan showed air‐liquid level, gas bubbles, or total opacification of either maxillary sinus, the patient underwent maxillary sinus aspiration under topical anesthesia. The aspirate was cultured to identify culture‐proven bacterial ARS as described earlier …”

Section: Methodsmentioning

confidence: 99%

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Imaging follow-up study of acute rhinosinusitis

et al. 2016

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“…Thirty‐nine patients (78%) had respiratory virus nucleic acid in their nasopharynx at enrolment . Twenty patients (40%) underwent a maxillary sinus aspiration.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Imaging follow-up study of acute rhinosinusitis

et al. 2016

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“…Although the recovery of viral agents from the nose in the setting of ARS has ranged from 27% to 84%, this may reflect the variability and limitations of the specific techniques used. 23,[122][123][124] Inoculation of rhinovirus in humans produced greater than a 90% infection rate with up to 74% displaying ARS symptoms. 125,126 It has been hypothesized that a preceding AVRS may be associated with subsequent ABRS by inhibition of mucociliary clearance (MCC) and blockade of sinus ostia due to local swelling.…”

Section: Vb Ars: Pathophysiologymentioning

confidence: 99%

“…132,133 For these reasons, studies that directly sample the sinuses during an infection are needed. Autio et al 124 found that up to 84% of patients presenting with ABRS had viral nucleic acid detected during the early phase of the disease (days 2 to 3), and a coinfection with bacteria (56%) during the viral infection was found to correlate with worse disease scores.…”

Section: Vb Ars: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

558

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

525

479

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I. Executive Summary Background The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

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The role of microbes in the pathogenesis of acute rhinosinusitis in young adults

Abstract: Nasal and paranasal H. influenzae coinfection during viral infection may modify the symptoms and the extent of sinonasal mucosal disease observed in CBCT scans already from the beginning of the ARS episode.

Cited by 24 publications

References 29 publications

Imaging follow-up study of acute rhinosinusitis

Imaging follow-up study of acute rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International consensus statement on allergy and rhinology: rhinosinusitis 2021

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