The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

McAlister, Emma; Kirkby, Melissa; Domínguez-Robles, Juan; Paredes, Alejandro J.; Anjani, Qonita Kurnia; Moffatt, Kurtis; Vora, Lalitkumar K.; Hutton, Aaron R.J.; McKenna, Peter E.; Larrañeta, Eneko; Donnelly, Ryan F.

doi:10.1016/j.addr.2021.06.002

Cited by 51 publications

(23 citation statements)

References 247 publications

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“…In clinical studies, the range of μND shaft length is highly regulated since the human skin is thicker compared to small animals [9,10,66]. Moreover, safety regulations are restricted to the utilisation of biocompatible polymers approved by the Food and Drug Administration (FDA), such as hyaluronic acid, gelatin, chitosan, and polyvinyl alcohol [9,10,[66][67][68]. Even though there have been many preclinical studies in the literature on dissolving μNDs, only a small number of clinical studies have been implemented on them (Fig.…”

Section: μNds Design Distinctions For Pre-clinical and Clinical Testingmentioning

confidence: 99%

Skin biomechanics: Breaking the dermal barriers with microneedles

et al. 2022

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Microneedles (μND) are promising devices that can be used to transport a wide variety of active compounds into the skin. To serve as an effective delivery system, μND must pierce the human stratum corneum (~10-20 μm), without breaking or buckling during penetration. In the current review, we discuss both the anatomical features and biomechanical properties of skin in order to understand the local environment and resistive forces relevant to μNDs insertion. Of particular importance are the factors that affect μND insertion, such as their geometry and material composition, as these can be manipulated in the design and development phase to optimise skin insertion. We review the research relevant to μND and how this interacts with skin properties. We have also reviewed the most commonly used skin drug diffusion modelling used to predict drug behaviour from μNDs, and discussed the current challenges faced by μNDs to enter clinical trials and provide positive clinical outcomes.

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Section: μNds Design Distinctions For Pre-clinical and Clinical Testingmentioning

confidence: 99%

Skin biomechanics: Breaking the dermal barriers with microneedles

et al. 2022

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“…Microneedle patches provide a promising platform for enhancing intradermal delivery of ''difficult to deliver'' therapies. Microneedle patches are minimally invasive devices that comprise multiple micron-scale projections on a patch [26][27][28][29]. The sharp and tiny projections can bypass the SC and deliver the drug into the viable layers of the skin without touching the nerves deeper in the skin [30].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections

Peng

Vora

Tekko

et al. 2021

Journal of Controlled Release

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“…Here, in this review, according to microneedle-based devices, MNs can be divided into five categories: solid, drug-coated, dissolvable, hollow and hydrogel-based microneedles (Figure 4) [31,32].…”

Section: Classification Of Microneedlesmentioning

confidence: 99%

Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

Cited by 51 publications

References 247 publications

Skin biomechanics: Breaking the dermal barriers with microneedles

Skin biomechanics: Breaking the dermal barriers with microneedles

Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections

Advances of Microneedles in Biomedical Applications

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