The role of microRNA-150 as a tumor suppressor in malignant lymphoma

Watanabe, Atsushi; Tagawa, Hiroyuki; Yamashita, Junsuke; Teshima, Kazuaki; Nara, Miho; Iwamoto, Keiko; Kume, Masaaki; Kameoka, Yoshihiro; Takahashi, Naoto; Nakagawa, Tsutomu; Shimizu, Norio; Sawada, Kenichi

doi:10.1038/leu.2011.81

Cited by 154 publications

(152 citation statements)

References 44 publications

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“…miR-150 has been reported as a hematopoietic-specific miRNA in malignant lymphoma and is significantly downregulated in tumor cells relative to healthy cells (18). In solid tumor tissue, miR-150 expression levels were reduced when compared to paired non-cancerous tissue in colorectal cancer, indicating that low miR-150 expression is associated with shorter survival and a worse response to adjuvant chemotherapy (19).…”

Section: A B C Dmentioning

confidence: 90%

Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features

Sun

Zhang

et al. 2012

Oncology Reports

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Abstract. The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, miR-643 and miR-3940-5p were detected by real-time PCR; p53, EGFR, Kras and Ki-67 expression in tumor tissues was determined by immunohistochemistry. p53 mRNA expression levels in NSCLC were examined by SYBR-Green real-time PCR. The relationship between the four miRNAs and clinicopathologic features of 90 cases was analyzed. The expression of miR-150 and miR-3940-5p was significantly downregulated in tumor tissues and embryonic lung tissues compared to normal lung tissues. The expression of miR-150 and miR-3940-5p in tumor tissues was also lower than that in the matched tumor-adjacent tissues. miR-150 was downregulated preferentially in subgroups of patients with a tumor diameter more than or equal to 3 cm, in smokers and in stage III and IV tumors. Specifically, miR-150 and miR-3940-5p expression was decreased in nuclear cell proliferation antigen Ki-67-positive NSCLC cases. miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA. Reduced miR-150 and miR-3940-5p expression in tumor tissues and embryonic lung tissues suggests that these miRs may be involved in the tumorigenesis or de-differentiation of NSCLC. Due to this associaton with the Ki-67 proliferation index in NSCLC, downregulation of miR-150 and miR-3940-5p may contribute to tumor growth and proliferation. miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway.

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Section: A B C Dmentioning

confidence: 90%

Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features

Sun

Zhang

et al. 2012

Oncology Reports

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“…The literature supports the notion that miR-150 plays different roles depending on cell context. Forced expression of miR-150 promoted proliferation of gastric cancer cells (Wu et al, 2010), whereas it increased the rate of apoptosis and reduced proliferation of NK/T lymphoma cells (Watanabe et al, 2011). miR-150 Tg mice have a reduced number of splenic B cells, and miR-150 Tg B cells from the BM showed increased sensitivity to apoptosis when cultured in vitro (Xiao et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

miR-150 regulates the development of NK and iNKT cells

Bezman¹,

Chakraborty²,

Bender³

et al. 2011

J Cell Biol

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“…The AKT family is also regulated by miRNAs. For example, AKT1 is suppressed by miR-149* [76] , AKT2 is suppressed by miR-184 and miR-150 [77,78] , and AKT3 is suppressed by the miR-15/16 cluster [79] . PTEN is an important tumor suppressor that antagonizes PI3K activity by inhibiting the transformation of PIP2 to PIP3.…”

Section: Pi3k/akt Pathwaymentioning

confidence: 99%

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

Liang

2011

Acta Pharmacol Sin

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The cell cycle, which is precisely controlled by a number of regulators, including cyclins and cyclin-dependent kinases (CDKs), is crucial for the life cycle of mammals. Cell cycle dysregulation is implicated in many diseases, including cancer. Recently, compelling evidence has been found that microRNAs play important roles in the regulation of cell cycle progression by modulating the expression of cyclins, CDKs and other cell cycle regulators. Herein, the recent findings on the regulation of the cell cycle by microRNAs are summarized, and the potential implications of miRNAs in anti-cancer therapies are discussed.

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The role of microRNA-150 as a tumor suppressor in malignant lymphoma

Cited by 154 publications

References 44 publications

Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features

Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features

miR-150 regulates the development of NK and iNKT cells

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

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