The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma

Aftab, Mohammad; Dinger, Marcel E.; Perera, Ranjan J.

doi:10.1016/j.abb.2014.07.022

Cited by 73 publications

(98 citation statements)

References 180 publications

(177 reference statements)

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“…This cluster is essential for inhibiting the proapoptotic moderator, Bcl-2L11 (BIM). Similar to this cluster, Georgantas et al reported that miR-506-514 cluster on chromosome X is overexpressed in melanoma (1,23,24). Overall, several miRNAs have been reported as key regulators of cell production, including miR-786-3p, miR-214, miR-155, and miR-126 (1).…”

Section: Cell-cycle Regulatory Overexpressed Mirnasmentioning

confidence: 79%

“…The small cell protein, WEE1 G2 checkpoint kinase (WEE1), as a mitotic inhibitor kinase, is another target of the cell cycle inhibitor, miR-195. As demonstrated by Watanabe et al in 2013, depletion of WEE1 due to miR-195 attachment enhances cell proliferation (1,14,15). Furthermore, in a study by Felicetti et al and Igoucheva et al, miR-221 and miR-222 were shown to be overexpressed.…”

Section: Cell-cycle Regulatory Overexpressed Mirnasmentioning

confidence: 86%

“…Loss (Table 1). In addition, melanoma metastasis decreases by miR-let-7b, which attenuates its essential target, basigin (BSG), and extracellular matrix metalloproteinase (MMP) (1,37). Similarly, miR-206 reduces the proliferation and invasion of melanoma cell lines by targeting CDK4, cyclin D1, and cyclin C, which are downregulated in melanoma (Figure 1) (38)(39)(40).…”

Section: Cell-cycle Regulatory Downregulated Mirnasmentioning

confidence: 99%

“…This gene modifies the cell surface of melanoma cells and affects cellular adherence; metastasis occurs due to discontinuity of cancerous cells. Therefore, miR-30b and miR-30 are accountable for metastasis in melanoma (1,21,22).…”

Section: Immunosuppressive Mirnasmentioning

confidence: 99%

“…MiRNAs are responsible for several molecular modifications in abnormal cells. Involvement of miRNAs in melanoma has been approved by many researchers (1)(2)(3)(4).…”

Section: Contextmentioning

confidence: 99%

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Melanoma and Associated MicroRNAs

2016

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Context: Melanoma is an invasive type of skin cancer, with a rapidly increasing incidence. Therefore, new approaches are required to treat this aggressive cancer. MicroRNAs (miRNAs) are introduced as novel components in melanoma. This review study aimed to determine the relationship between melanoma and miRNAs. Evidence Acquisition: Prognostic, diagnostic, and therapeutic applications of miRNAs in skin cancer have been recently investigated from different aspects. Some of these studies on miRNAs were reviewed, and the mechanisms of some genetic modifications were determined in this study. Results: Since recommendations for miRNAs have increased in the past decades, and scientists have confirmed their great efficacy in multiple aspects of cancer treatment, different strategies have been developed considering their therapeutic effects. Therefore, further studies are required to confirm miRNA application in melanoma treatment. Conclusions: This review study included various investigations concerning miRNA traces as molecular rearrangements in melanoma. It was revealed that multiple miRNAs are efficient in molecular signaling and can be used as prognostic, diagnostic, and therapeutic biomarkers. Although the exact relationship between aberrant expression of miRNAs and cancers has been confirmed, further studies are required to introduce more thorough and accurate applications of miRNAs in melanoma.

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Section: Cell-cycle Regulatory Overexpressed Mirnasmentioning

confidence: 79%

Section: Cell-cycle Regulatory Overexpressed Mirnasmentioning

confidence: 86%

Section: Cell-cycle Regulatory Downregulated Mirnasmentioning

confidence: 99%

Section: Immunosuppressive Mirnasmentioning

confidence: 99%

“…MiRNAs are responsible for several molecular modifications in abnormal cells. Involvement of miRNAs in melanoma has been approved by many researchers (1)(2)(3)(4).…”

Section: Contextmentioning

confidence: 99%

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Melanoma and Associated MicroRNAs

2016

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Clinical significance of long noncoding RNA SPRY4‐IT1 in melanoma patients

Shen

Xiong³

et al. 2016

FEBS Open Bio

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Long noncoding RNA SPRY 4‐ IT 1 has been reported to promote melanoma cell growth and invasion, and to block apoptosis. The purpose of this study was to investigate the clinical significance of SPRY 4‐ IT 1 in patients with malignant melanoma. The relative expression levels of SPRY 4‐ IT 1 were measured in plasma samples from 70 patients and 79 healthy controls by quantitative reverse transcriptase polymerase chain reaction. SPRY 4‐ IT 1 expression is high in melanoma patients but low in healthy controls, and is closely associated with tumor site and tumor stage. Elevated SPRY 4‐ IT 1 significantly reduces overall survival rates of patients and is considered as an independent prognostic factor in patients with melanoma. The prognostic nomogram shows a good prediction of the probability of 5‐year overall survival of patients with melanoma (c‐index: 0.72). The calibration curve for the probability of survival presents good agreement between actual outcomes and predictive consequences. In summary, SPRY 4‐ IT 1 may be a potential prognostic marker and a potential therapeutic target.

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TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis

Kong

Qiu

et al. 2019

Biopharm & Drug Disp

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Multidrug resistance (MDR) is common in patients and has been linked to transforming growth factor‐β1 (TGF‐β1) and overexpression of drug efflux transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP), although the molecular mechanisms remain largely unknown. This study aimed to investigate the mechanisms underlying TGF‐β1‐induced MDR in hepatocellular carcinoma (HCC) cells. It was found that TGF‐β1 upregulated HOX transcript antisense RNA (HOTAIR) expression in HCC cells. When drosophila mothers against decapentaplegic 4 (SMAD4) was silenced, HOTAIR expression was accordingly reduced. Meanwhile, miR‐145 expression was increased in the case HOTAIR was silenced. If the enhancer of zeste homolog 2 (EZH2) was knocked down using small interfering RNA (siRNA), miR‐145 expression was decreased. Then, the regulatory role of miR‐145 in P‐gp and BCRP expression was explored. The results showed that the expression of P‐gp and BCRP protein was suppressed by miR‐145 through binding to the 3′‐untranslated regions (3′‐UTRs) of P‐gp and BCRP. In conclusion, our study revealed a novel mechanism explaining TGF‐β1‐induced MDR in HCC through upregulating P‐gp and BCRP via the SMAD4/HOTAIR/miR‐145 axis.

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The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma

Cited by 73 publications

References 180 publications

Melanoma and Associated MicroRNAs

Melanoma and Associated MicroRNAs

Clinical significance of long noncoding RNA SPRY4‐IT1 in melanoma patients

TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis

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