Clinical significance of long noncoding RNA SPRY4‐IT1 in melanoma patients

Abstract

Long noncoding RNA SPRY 4‐ IT 1 has been reported to promote melanoma cell growth and invasion, and to block apoptosis. The purpose of this study was to investigate the clinical significance of SPRY 4‐ IT 1 in patients with malignant melanoma. The relative expression levels of SPRY 4‐ IT 1 were measured in plasma samples from 70 patients and 79 healthy controls by quantitative reverse transcriptase polymerase chain reaction. SPRY 4‐ IT 1 expression is high in melanoma patients but low in healthy controls, and is closely associated with tumor site and tumor stage. Elevated SPRY 4‐ IT 1 significantly reduces overall survival rates of patients and is considered as an independent prognostic factor in patients with melanoma. The prognostic nomogram shows a good prediction of the probability of 5‐year overall survival of patients with melanoma (c‐index: 0.72). The calibration curve for the probability of survival presents good agreement between actual outcomes and predictive consequences. In summary, SPRY 4‐ IT 1 may be a potential prognostic marker and a potential therapeutic target.

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers

“…Decreased SPRY4-IT1 expression can inhibit melanoma cell proliferation, motility, and invasion and increase the rates of apoptotic cells. 24 Liu et al 10 investigated the clinical significance of SPRT4-IT1 in melanoma patients and found that SPRY4-IT1 was upregulated in the blood of melanoma patients compared with that in healthy volunteers. High SPRY4-IT1 expression was positively correlated with tumor site and tumor-node-metastasis (TNM) stage and negatively associated with overall survival (OS) rates.…”

Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma

“…In addition, when these genes were put into enrichment analysis, the results implied that immunization was considered to play a crucial role in the development of CM, as plenty of pathways and functions were associated with immunity. To date, dozens of pathways, such as the integrin/FAK signaling pathway , the KMT2A/hTERT signaling pathway , the PI3K/AKT/mTOR autophagy signaling pathway , and the Wnt signaling pathway , have been determined to somewhat govern the development of CM by disrupting the biological functions of melanocytes. Further statistical analysis of the association between gene expression and the clinical information of CM highlighted several genes, including two lncRNAs, which may influence the outcome of CM patients.…”

Upregulation of long noncoding RNA SPRY4‐IT1 correlates with tumor progression and poor prognosis in cervical cancer

“…Furthermore, Liu et al . has demonstrated that lncRNA SPRY4‐IT1 was increased in the plasma of melanoma patients compared to that in healthy controls, and served as an independent predictor for overall survival. In addition, SPRY4‐IT1 was also upregulated in esophageal squamous cell carcinoma , prostate cancer , and gastric cancer .…”

“…The SPRY4‐IT1 has demonstrated its overexpression and amplification in multiple cancer types , indicating that it may promote carcinogenesis. Moreover, SPRY4‐IT1 expression has been remarkably correlated with clinical characteristics such as risk, relapse, progression in esophageal squamous cell carcinoma (ESCC) , nonsmall‐cell lung cancer (NSCLC) , clear cell renal cell carcinoma (ccRCC) , gastric cancer , bladder cancer , and melanoma .…”