Upregulation of long noncoding RNA SPRY4‐IT1 correlates with tumor progression and poor prognosis in cervical cancer

Cao, Yang; Liu, Yinglei; Lu, Xin; Wang, Ying; Qiao, Haifeng; Liu, Manhua

doi:10.1002/2211-5463.12102

Cited by 28 publications

(33 citation statements)

References 22 publications

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“…Sensitivity to cisplatin, therefore, was predicted to be mediated by DNA repair pathways (Rosell et al ., ). In view of the roles of FEN1 in multiple repair processes, such as BER (Simpson et al ., ), nonhomologous end‐joining (Cao et al ., ), HR (Hu et al ., ; Liu et al ., ), NER (Herrero et al ., ; Mocquet et al ., ; Zhao et al ., ), and mismatch repair (MMR; Liu et al ., ), it was pertinent to speculate that the high level of FEN1 expression in tumors contributed to intrinsic or acquired drug resistance. To test this hypothesis, we performed drug‐sensitive experiments in A549 lung cancer cells with different FEN1 levels.…”

Section: Resultsmentioning

confidence: 99%

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

et al. 2017

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Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic effect of chemotherapy is limited due to the resistance of cancer cells, which remains a challenge in cancer therapeutics. In this work, we found that flap endonuclease 1 (FEN1) is overexpressed in lung cancer cells. FEN1 is a major component of the base excision repair pathway for DNA repair systems and plays important roles in maintaining genomic stability through DNA replication and repair. We showed that FEN1 is critical for the rapid proliferation of lung cancer cells. Suppression of FEN1 resulted in decreased DNA replication and accumulation of DNA damage, which subsequently induced apoptosis. Manipulating the amount of FEN1 altered the response of lung cancer cells to chemotherapeutic drugs. A small‐molecule inhibitor (C20) was used to target FEN1 and this enhanced the therapeutic effect of cisplatin. The FEN1 inhibitor significantly suppressed cell proliferation and induced DNA damage in lung cancer cells. In mouse models, the FEN1 inhibitor sensitized lung cancer cells to a DNA damage‐inducing agent and efficiently suppressed cancer progression in combination with cisplatin treatment. Our study suggests that targeting FEN1 may be a novel and efficient strategy for a tumor‐targeting therapy for lung cancer.

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Section: Resultsmentioning

confidence: 99%

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

et al. 2017

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“…15 In addition, elevated serum HOTAIR was implicated in late stage tumours, adenocarcinomas, lymphatic vessel infiltration, and lymph node metastasis. 17,18 In this study, lncOGFRP1 was first found to be highly expression in CC, but it was not associated with the patient's prognosis. 15 In contrast, GAS5 is downregulated in CC tissues, which is significantly associated with advanced cancer progression and has been identified as an independent biomarker of clinical status in patients with CC.…”

Section: Prognosis and Progressionmentioning

confidence: 69%

“…16 In addition, TUSC8, SPRY4-IT1, and lncRNA-LET are also considered as promising markers for CC. 17,18 In this study, lncOGFRP1 was first found to be highly expression in CC, but it was not associated with the patient's prognosis. This result may be related to the small sample size.…”

Section: Prognosis and Progressionmentioning

confidence: 69%

Silencing long noncoding RNA OGFRP1 inhibits the proliferation and migration of cervical carcinoma cells

Zou

Chen

et al. 2019

Cell Biochemistry & Function

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Cervical cancer is still a serious threat to women's health and life safety worldwide, and new treatment strategies are urgently needed. Accumulating evidences also imply that long non-coding RNAs (lncRNAs) are involved in a wide range of cellular processes, such as cell proliferation, apoptosis, and cell cycle. We found that the expression of lncOGFRP1 in cervical cancer tissues was significantly higher than that in normal cervical tissues (P < .05). Further, CCK8 detection found when lncOGFRP1 was silenced, the proliferation of cells was inhibited. After depleting lncOGFRP1, the proportion of apoptosis cells in C33A (3.71 ± 0.38% VS 11.98 ± 1.26%, P < .05) and SiHa (0.69 ± 0.06% VS 11.06 ± 1.03%, P < .05) cells increased significantly, and cell cycle was arrested in S phase. On the other hand, migration detection found the migration of cells also was hindered when lncOGFRP1 level was reduced. And the depletion of lncOGFRP1 inhibited the expression of β-catenin, Vimentin, N-cadherin, and SNAIL and promoted the expression of E-cadherin. In summary, we first discovered the high expression of lncOGFRP1 in cervical cancer and revealed that silencing lncOGFRP1 inhibits the proliferation and migration of cervical carcinoma cells. Significance of the study:We first discovered the high expression of lncOGFRP1 in cervical cancer and revealed that silencing lncOGFRP1 inhibits the proliferation and migration of cervical carcinoma cells. These results help to better understand the pathogenesis and development of cervical cancer and provide insight to develop better diagnosis and treatment strategies.

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“…Cao et al (77), showed that SPRY4-IT1 expression is a good candidate marker for discriminating between tumor tissue and normal tissue and for predicting poor prognoses in patients with cervical cancer.…”

Section: Spry4-it1 Spry4-it1mentioning

confidence: 99%

Long non-coding RNAs on the stage of cervical cancer

Dong

Chang

et al. 2017

Oncology Reports

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Cervical cancer is one of most malignant gynecological tumors. However, effective means for diagnosing and treating cervical cancer have yet to be identified. A few decades ago, long non-coding RNAs (lncRNAs) were regarded as useless parts of the genome, however, increasing data have demonstrated the importance of lncRNAs in the diagnosis and treatment of cervical cancers. The aim of the present study is to summarize the role(s) of HOTAIR, MALAT1, CCAT2, SPRY4-IT1, RSU1P2, CCHE1, lncRNA-EBIC and PVT1. Approximately 14 lncRNAs are involved in cervical cancer and several important proteins, miRNAs and other molecules and play crucial roles in a few traditional signaling pathways that have been proven to be related to those lncRNAs. In conclusion, lncRNAs may be useful as exact treatment targets and diagnostic biomarkers for improving therapies in cervical cancer patients and lncRNAs may contribute to effective diagnosis and treatment methods for cervical cancer.

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Upregulation of long noncoding RNA SPRY4‐IT1 correlates with tumor progression and poor prognosis in cervical cancer

Cited by 28 publications

References 22 publications

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

Silencing long noncoding RNA OGFRP1 inhibits the proliferation and migration of cervical carcinoma cells

Long non-coding RNAs on the stage of cervical cancer

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