The role of microRNAs in the pathogenesis of autoimmune diseases

Chen, Ji-Qing; Papp, Gábor; Szodoray, Péter; Zeher, Margit

doi:10.1016/j.autrev.2016.09.003

Cited by 250 publications

(177 citation statements)

References 115 publications

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“…Since altered expression levels of several miRNAs have been reported in the PBMCs of patients with SS (21). The present study further investigated the dysregulation of miRNAs in the labial salivary gland tissue.…”

Section: Resultsmentioning

confidence: 99%

“…According to the mentioned SS criteria, labial salivary gland biopsy occupies a very important position in the diagnosis of SS (14,23), although this is an invasive procedure. Recently, an increasing number of studies revealed that miRNAs in PBMCs, sera and saliva contribute to the pathogenesis of SS and may represent a novel class of diagnostic biomarkers for this disease (8,10,11,21). However, studies investigating the miRNA profiles in the salivary gland tissue of SS patients are currently lacking.…”

Section: Discussionmentioning

confidence: 99%

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Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Wang

Zhang

et al. 2017

Exp Ther Med

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Abstract. Sjögren syndrome (SS) is characterized by dysfunction of the exocrine glands, particularly the salivary and lacrimal glands. Thus, labial salivary gland biopsy is useful method for diagnosing SS. The aim of the present study was to investigate the microRNA (miRNA or miR) profile of labial salivary glands obtained from SS patients and to examine the correlation of miR-181a and -16 levels with the pathological grade in SS. miRNA expression in labial salivary gland tissues was profiled in 3 female patients with primary SS and 3 female patients with non-SS sicca syndrome using microarray analysis. In addition, a literature search and miRNA target gene prediction were performed to collect miRNAs involved in SS pathogenesis. Subsequent to integrating all database results, miR-181a and -16 were identified to be associated with the Ro/SS-associated antigen A and La/SS-associated antigen B during SS pathogenesis. Therefore, these miRNAs were selected for further verification in labial salivary gland tissues of 28 patients with SS and 18 non-SS sicca syndrome control individuals by quantitative reverse transcription-quantitative polymerase chain reaction. Compared with the control group, 76 miRNAs were upregulated and 51 were downregulated in the labial salivary gland of SS patients according to microarray results. In particular, miR-181a and -16 expression levels in the labial salivary gland of SS patients were decreased in comparison with those in the controls. Furthermore, the decreased expression levels of these miRNAs were associated with the labial salivary pathological focus scores. In conclusion, the present study examined the miRNA profiles in the labial salivary glands of SS patients and detected decreased miR-181a and -16 expression levels compared with the control individuals. Finally, the decreased levels of miR-181a and -16 were associated with the salivary gland pathological focus scores, suggesting that miR-181a and -16 may serve a role in the pathogenesis of SS.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Wang

Zhang

et al. 2017

Exp Ther Med

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“…Indeed, this was recently demonstrated both in an experimental tumor microenvironment and in a model of neuronal damage [157,158]. miRNA expression is dysregulated in many diseases, including SLE and psoriasis [159,160]. It is therefore possible that miRNAs released by diseased tissues may concur for pDCs activation also in autoimmune contexts.…”

Section: Activation In Autoimmune Diseasesmentioning

confidence: 99%

Dendritic cell recruitment and activation in autoimmunity

Sozzani

Prete

Bosisio

2017

Journal of Autoimmunity

108

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“…MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs, of approximately 23 nucleotides in length, that regulate gene expression at the post-transcriptional level (Krol et al, 2010) and are associated with various autoimmune diseases (Singh et al, 2013; Chen et al, 2016). Multiple miRNAs have roles in the development of EAE through targeting specific proteins in relevant Th17 cell pathways.…”

Section: Introductionmentioning

confidence: 99%

MiR-384 Regulates the Th17/Treg Ratio during Experimental Autoimmune Encephalomyelitis Pathogenesis

Han

Zhang

et al. 2017

Front. Cell. Neurosci.

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Specific miRNAs are involved in the pathogenesis of multiple sclerosis (MS), during which IL-17-producing CD4+ T helper (Th17) cells accumulate in the central nervous system (CNS). In this study, we identified levels of miR-384 as significantly increased in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Over-expression of miR-384 in vivo led to severe EAE, characterized by exacerbated demyelination, and increased inflammatory cell infiltration of the spinal cord; inhibition of miR-384 reversed these changes. Both the percentage of Th17, and ratio of Th17/regulatory T (Treg), cells were elevated in miR-384-transfected EAE mice, which was consistent with the observed upregulation of expression of IL-17 and the Th17 lineage-specific transcription factor, RORγt. Importantly, transfer of miR-384 overexpressing naïve T cells from wild-type (WT) to Rag1−/− mice, which are deficient in functional autologous T and B cells, led to aggravated EAE pathogenesis, while an miR-384 inhibited group was protected from EAE. Moreover, miR-384 promoted differentiation of naïve T cells into Th17 cells in vitro. Furthermore, target prediction and dual luciferase reporter assays demonstrated that suppressor of cytokine signaling 3 (SOCS3), a gene encoding protein with an established role in Th17 differentiation, was a direct target of miR-384. Our results demonstrate an important role for miR-384 in regulation of the Th17/Treg ratio during the pathogenesis of EAE, indicating that this molecule may have potential as a biomarker and/or therapeutic target in MS.

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The role of microRNAs in the pathogenesis of autoimmune diseases

Cited by 250 publications

References 115 publications

Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Decreased microRNA-181a and -16 expression levels in the labial salivary glands of Sjï¿½gren syndrome patients

Dendritic cell recruitment and activation in autoimmunity

MiR-384 Regulates the Th17/Treg Ratio during Experimental Autoimmune Encephalomyelitis Pathogenesis

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