The Role of MicroRNAs in Selected Forms of Glomerulonephritis

Nalewajska, Magdalena; Gurazda, Klaudia; Styczyńska-Kowalska, Ewa; Marchelek-Myśliwiec, Małgorzata; Pawlik, Andrzej; Dziedziejko, Violetta

doi:10.3390/ijms20205050

Cited by 22 publications

(26 citation statements)

References 39 publications

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“…Low level of a microRNA in LN was found to cause dysregulation of the podocyte cytoskeleton and another causing deficiency in E-cadherin and intercellular adhesion. 45 Chronic inflammation leads to cell death. Cellular regeneration and laying down of fibrotic material, leads to glomerulosclerosis.…”

Section: Lupus Nephritis Pathophysiologymentioning

confidence: 99%

<p>Towards Precision Medicine in Systemic Lupus Erythematosus</p>

Lever¹,

Alves²,

Isenberg³

2020

PGPM

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Systemic lupus erythematosus (SLE) is a remarkable condition characterised by diversity amongst its clinical features and immunological abnormalities. In this review, we attempt to capture the major immunological changes linked to the pathophysiology of lupus and discuss the challenge it presents in moving towards the concept of precision medicine. Currently broadly similar types of drugs, e.g., steroids, immunosuppressives, hydroxychloroquine are used to treat many of the diverse clinical features of SLE. We suspect that, as the precise immunopathological abnormalities differ between the various organs/systems in lupus patients, it will be some time before precision medicine can be fully applied to SLE.

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Section: Lupus Nephritis Pathophysiologymentioning

confidence: 99%

<p>Towards Precision Medicine in Systemic Lupus Erythematosus</p>

Lever¹,

Alves²,

Isenberg³

2020

PGPM

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“…Contributions from miRNAs to inflammatory processes have been demonstrated for a multitude of diseases (123), including rheumatoid arthritis (126), psoriasis (124), asthma (78), ulcerative colitis (147), systemic lupus erythematosus (133), different forms of glomerulonephritis (93), and also atherosclerosis (51,127).…”

Section: Neutrophil Leukocytesmentioning

confidence: 99%

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

Knappich

Spin

Eckstein

et al. 2020

Antioxidants & Redox Signaling

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Significance: Abdominal aortic aneurysm (AAA) is a potentially fatal condition, featuring the possibility of high-mortality rupture. To date, prophylactic surgery by means of open surgical repair or endovascular aortic repair at specific thresholds is considered standard therapy. Both surgical options hold different risk profiles of short-and long-term morbidity and mortality. Targeting early stages of AAA development to decelerate disease progression is desirable. Recent Advances: Understanding the pathomechanisms that initiate formation, maintain growth, and promote rupture of AAA is crucial to developing new medical therapeutic options. Inflammatory cells, in particular macrophages, have been investigated for their contribution to AAA disease for decades, whereas evidence on lymphocytes, mast cells, and neutrophils is sparse. Recently, there has been increasing interest in noncoding RNAs (ncRNAs) and their involvement in disease development, including AAA. Critical Issues: The current evidence on myeloid cells and ncRNAs in AAA largely originates from small animal models, making clinical extrapolation difficult. Although it is feasible to collect surgical human AAA samples, these tissues reflect end-stage disease, preventing examination of critical mechanisms behind early AAA formation. Future Directions: Gaining more insight into how myeloid cells and ncRNAs contribute to AAA disease, particularly in early stages, might suggest nonsurgical AAA treatment options. The utilization of large animal models might be helpful in this context to help bridge translational results to humans. Antioxid. Redox Signal. 00, 000-000.

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“…Even more data have been accumulated in regard to SLE. Many recent findings illuminate transcriptional regulation and chromatin modification as the critical point for development of autoimmunity, including connective tissue diseases [62][63][64][65][66][67]. Following the first study in 2007, hundreds of miRNAs have been identified as having a potential role in modulating the immune system toward autoimmune response.…”

Section: Microrna In Autoimmunitymentioning

confidence: 99%

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

Kotyla

Islam

2020

IJMS

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MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.

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The Role of MicroRNAs in Selected Forms of Glomerulonephritis

Cited by 22 publications

References 39 publications

<p>Towards Precision Medicine in Systemic Lupus Erythematosus</p>

<p>Towards Precision Medicine in Systemic Lupus Erythematosus</p>

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

MicroRNA (miRNA): A New Dimension in the Pathogenesis of Antiphospholipid Syndrome (APS)

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