The role of microRNAs in colorectal cancer

Mohammadi, Ali; Mansoori, Behzad; Baradaran, Behzad

doi:10.1016/j.biopha.2016.09.099

Cited by 146 publications

(104 citation statements)

References 99 publications

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“…Increasing data findings have indicated miRNAs to be critical regulators of cancer-related processes, but it is still unknown the molecu lar mechanisms by which miRNAs modulate the behavior of cancer cells (26,27). miR-346 has been reported as an oncomir because it facilitates cell growth and metastasis in various human cancers (16)(17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

miRNA-346 promotes proliferation, migration and invasion in liver cancer

Xia

Duan

et al. 2017

Oncology Letters

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Abstract. Liver cancer primarily accounts for the majority of malignancies of the liver. MicroRNAs (miRNAs) are endogenous non-coding RNAs, which are important in tumorigenesis. Abnormal expression of microRNA-346 (miR-346) has been demonstrated in various types of human cancer, however, its expression and potential molecular mechanism in liver cancer remains to be elucidated. Expression levels of miR-346 in liver cancer cell lines were determined by quantitative polymerase chain reaction. The effect of miR-346 on proliferation was evaluated by an MTT assay; cell migration and invasion were evaluated by Transwell migration and invasion assays and target protein expression was determined by western blotting. The present study observed that miR-346 was upregulated in liver cancer cell lines. miR-346 overexpression promoted cell proliferation, migration and invasion in liver cancer cells and conversely, inhibition of miR-346 resulted in the opposite effects. Furthermore, F-Box and leucine rich repeat protein (FBXL)2 was identified as a direct target of miR-346. miR-346 promoted proliferation, migration and invasion of liver cancer via FBXL2. Overall, these findings demonstrated that miR-346 may act as a potential prognostic marker and therapeutic target against liver cancer in the future.

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Section: Discussionmentioning

confidence: 99%

miRNA-346 promotes proliferation, migration and invasion in liver cancer

Xia

Duan

et al. 2017

Oncology Letters

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“…MIMAT0000067 (hsa-let-7g) is associated with tumorigenesis in colon cancer [34], and MIMAT0000438 (hsa-mir-152) is associated with cell proliferation, migration, and invasion in human cancer [35]. MIMAT0004598 (hsa-miR-141) is used as a novel biomarker for metastatic colon cancer [36]. …”

Section: Resultsmentioning

confidence: 99%

Computational Analysis of Specific MicroRNA Biomarkers for Noninvasive Early Cancer Detection

Song

Liang

Cao

et al. 2017

BioMed Research International

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Cancer is a complex disease residing in various tissues of human body, accompanied with many abnormalities and mutations in genomes, transcriptome, and epigenome. Early detection plays a crucial role in extending survival time of all major cancer types. Recent advances in microarray and sequencing techniques have given more support to identifying effective biomarkers for early detection of cancer. MicroRNAs (miRNAs) are more and more frequently used as candidates for biomarkers in cancer related studies due to their regulation of target gene expression. In this paper, the comparative analysis is used to discover miRNA expression patterns in cancer versus normal samples on early stage of eight prevalent cancer types. Our work focuses on the specific miRNAs biomarkers identification and function analysis. Several identified miRNA biomarkers in this paper are matched well with those reported in existing researches, and most of them could serve as potential candidate indicators for clinical early diagnosis applications.

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“…Therefore, these miRNAs could be detected from serum and plasma, andcould be used as biomarkers for diagnosis. Interestingly, the circulating miRNAs in blood have been recently found to be covered into a complexes, known as exosomes, which are protected from RNase degradation and become more stable [21]. As well as detection in peripheral blood, CRC-specific miRNA could also be detected in stool.…”

Section: Clinical Significance Of Mirnas In Colorectal Cancermentioning

confidence: 99%

Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis

Guo

Bao

Yang

2017

IJMS

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Colorectal cancer is one of the most common malignancies and is the second-leading cause of cancer-related death world-wide, which is linked to genetic mutations, epigenetic alterations, and oncogenic signaling activation. MicroRNAs, one of the categories of epigenetics, have been demonstrated significant roles in carcinogenesis and progression through regulating of oncogenic signaling pathways, stem cells, epithelial-mesenchymal transition, and metastasis. This review summarizes the roles of microRNAs in the regulating of Wnt, Ras, TGF-β, and inflammatory signaling pathways, stemness, and epithelial-mesenchymal transition, for carcinogenesis and metastasis in colorectal cancer. Improving our understanding of the mechanisms of regulatory interactions of microRNAs with signaling pathways in colorectal cancer formation and progression will aid in determining the genes responsible for colorectal cancer initiation, progression, metastasis, and recurrence and, finally, in developing personalized approaches for cancer prevention and therapy.

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The role of microRNAs in colorectal cancer

Cited by 146 publications

References 99 publications

miRNA-346 promotes proliferation, migration and invasion in liver cancer

miRNA-346 promotes proliferation, migration and invasion in liver cancer

Computational Analysis of Specific MicroRNA Biomarkers for Noninvasive Early Cancer Detection

Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis

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