The role of microRNAs in gallbladder cancer

Yang, Guolong; Zhang, Lei; Li, Ruixiang; Wang, Lin

doi:10.3892/mco.2016.905

Cited by 25 publications

(14 citation statements)

References 94 publications

(96 reference statements)

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“…GBC is one of the most common malignant gastrointestinal tumors in the world, accounting for 80-95% of global biliary carcinoma, and is also the main cause of global biliary malignant tumor-related death. [169][170][171] GBC is a highly aggressive and fatal disease whose incidence is closely related to geography, race, and gender. 170,172 Because of the lack of specific symptoms of GBC or reliable sensitive markers, it is difficult to diagnose GBC at an early stage, resulting in low survival rate.…”

Section: Mir-34a In Gbcmentioning

confidence: 99%

<p>A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer</p>

Kong¹,

Wang²

2020

OTT

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MicroRNAs (miRNAs) are a class of endogenous non-coding single-stranded small-molecule RNAs that regulate gene expression by repressing target messenger RNA (mRNA) translation or degrading mRNA. miR-34a is one of the most important miRNAs participating in various physiological and pathological processes. miR-34a is abnormally expressed in a variety of tumors. The roles of miR-34a in gastrointestinal cancer (GIC) draw lots of attention. Numerous studies have demonstrated that dysregulated miR-34a is closely related to the proliferation, differentiation, migration, and invasion of tumor cells, as well as the diagnosis, prognosis, treatment, and chemo-resistance of tumors. Thus, we systematically reviewed the abnormal expression and regulatory roles of miR-34a in GICs including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), pancreatic cancer (PC), and gallbladder cancer (GBC). It may provide a profile of versatile roles of miR-34a in GICs.

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Section: Mir-34a In Gbcmentioning

confidence: 99%

<p>A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer</p>

Kong¹,

Wang²

2020

OTT

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“…Therefore, circulating miRNAs may be noninvasive and specific diagnostic and/or prognostic molecular biomarkers for human diseases, including cancer [4, 7, 58, 59]. In BTCs, many circulating miRNAs seem to be reproducible and reliable potential biomarkers as well as possible therapeutic targets [60].…”

Section: Circulating Mirnas As Potential Btcs Biomarkersmentioning

confidence: 99%

“…miRNAs are small noncoding RNAs (18–25 nucleotides) that play important roles in the regulation of a large number of essential biological functions that are critical to the development of different cancer types, including cell proliferation, differentiation, apoptosis, migration, and invasion [7]. …”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

Martins

Oliveira

Bona

et al. 2016

Gastroenterology Research and Practice

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Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.

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“…Thus, miRNA expressions are extensively examined in many cancer tissues and blood samples. Furthermore, the abnormal expression of miRNAs is widely investigated in numerous cancer types, including bladder cancer, 6 breast cancer, 7 gallbladder cancer, 8 and lung cancer. 9 Furthermore, miRNAs play a critical role in various cancer cellular processes, such as development, proliferation, apoptosis, migration, invasion, and drug resistance.…”

Section: Micro-rna and Lung Cancermentioning

confidence: 99%

Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation

Qin

Yan

et al. 2017

Tumour Biol.

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To understand the mechanism involved in gefitinib resistance, we established gefitinib-resistant human HCC827/GR-8-1 cell line from the parental HCC827 cell line. We compared the micro-RNA expression profiles of the HCC827 cells HCC827/GR-8-1 using Agilent micro-RNA microarrays. The micro-RNAs, such as the miR-149-5p, were up-or downregulated and associated with acquired gefitinib resistance. Quantitative real-time polymerase chain reaction was then performed to verify the expression patterns of different micro-RNAs. The result showed that miR-149-5p was upregulated in the HCC827/GR-8-1 cell line. To investigate the biological function of miR-149-5p in non-small cell lung cancer cells acquired gefitinib resistance, we examined cell proliferation using a cell counting kit-8 assay. Cell viability was evaluated after the miR-149-5p mimics, inhibitors, and negative control were separately transfected into the non-small cell lung cancer cells. The results showed that the non-small cell lung cancer cells transfected with miR-149-5p mimics exhibited reduced cell motility. The drug-sensitivity assay results revealed that the overexpression of miR-149-5p effectively evaluates the half maximal inhibitory concentration values of the cell in response to gefitinib, and the downregulation of miR-149-5p can attenuate the half maximal inhibitory concentration values of the cell lines in response to gefitinib. Furthermore, the levels of miR-149-5p in the HCC827 and HCC827/GR-8-1 cells were inversely correlated with caspase-3 expression. In conclusion, this study revealed that miR-149-5p is upregulated in the HCC827/ GR-8-1 cells and involved in the acquired gefitinib resistance.

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The role of microRNAs in gallbladder cancer

Cited by 25 publications

References 94 publications

<p>A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer</p>

<p>A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer</p>

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation

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